Efficacy and safety of weekly vitamin D3 in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial

Lozano-Plata, Luis Iván; Vega‐Morales, David; Esquivel-Valerio, Jorge Antonio; Garza‐Elizondo, Mario Alberto; Galarza‐Delgado, Dionicio Ángel; Silva-Luna, Karina; Serna-Peña, Griselda; Sifuentes-Ramírez, Janeth; Garza-Guerra, Alfredo de Jesús; Rivera, R

doi:10.1007/s10067-021-05640-8

Cited by 11 publications

(15 citation statements)

References 33 publications

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“…The full texts of the 27 remaining studies were read, and their content was cross-referenced with the inclusion criteria. A total of 14 studies met the eligible criteria [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. Details regarding the included studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…There was no significant difference between vitamin D and placebo groups in subjects with chronic lower-back pain (CLBP) who were treated with home-exercise and celecoxib prescriptions [ 34 ]. Similarly, Lozano-Plata [ 42 ] did not observe improvements in VAS or Fibromyalgia Impact Questionnaire (FIQ) in vitamin D-supplemented subjects compared with placebo. Furthermore, in the study by Scheuder et al [ 31 ], VAS scores for pain did not improve significantly after vitamin D supplementation, but the authors found a small positive effect on the Likert pain self-assessment scale.…”

Section: Resultsmentioning

confidence: 99%

“…The risk of bias in the primary studies based on the Cochrane risk-of-bias tool is shown in Figure 2 . There was “high risk” of bias in six studies [ 29 , 32 , 38 , 39 , 41 , 42 ], whereas six papers had “low risk” [ 33 , 34 , 35 , 36 , 37 , 40 ], and two manuscripts had “some concerns” [ 30 , 31 ]. The overall risk of bias is illustrated in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

“…In accordance, in a previous study, we demonstrated in obese patients that weight loss leads to an increase in circulating 25OHD even without supplementation [ 66 ]. The present systematic literature review identified three studies [ 29 , 32 , 42 ] that observed scarce analgesic effects of vitamin D supplementation which did not improve VAS scores. Nevertheless, data from these studies showed a high risk of bias.…”

Section: Discussionmentioning

confidence: 99%

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The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

Lombardo¹,

Feraco

Ottaviani³

et al. 2022

Nutrients

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Fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP) are diffuse suffering syndromes that interfere with normal activities. Controversy exists over the role of vitamin D in the treatment of these diseases. We carried out a systematic literature review of randomized controlled trials (RCT) to establish whether vitamin D (25OHD) deficiency is more prevalent in CMP patients and to assess the effects of vitamin D supplementation in pain management in these individuals. We searched PubMed, Physiotherapy Evidence Database (PEDro), and the Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs published in English from 1 January 1990 to 10 July 2022. A total of 434 studies were accessed, of which 14 satisfied the eligibility criteria. In our review three studies, of which two had the best-quality evidence, a correlation between diffuse muscle pain and 25OHD deficiency was confirmed. Six studies, of which four had the best-quality evidence, demonstrated that appropriate supplementation may have beneficial effects in patients with established blood 25OHD deficiency. Eight studies, of which six had the best-quality evidence, demonstrated that 25OHD supplementation results in pain reduction. Our results suggest a possible role of vitamin D supplementation in alleviating the pain associated with FMS and CMP, especially in vitamin D-deficient individuals.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

Lombardo¹,

Feraco

Ottaviani³

et al. 2022

Nutrients

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show abstract

“…In the light of the aforementioned hypotheses, the integration of vitamin D in patients with fibromyalgia appears rational to reduce pain and improve the quality of life. However, some authors suggest the lack of efficacy of supplementation with vitamin D in fibromyalgia patients [ 27 , 44 , 45 , 46 ]. Two controlled studies [ 47 , 48 ] found no correlation between low vitamin D levels and widespread musculoskeletal pain, as well as observed no significant improvement in musculoskeletal symptoms or quality of life after vitamin D supplementation.…”

Section: Discussionmentioning

confidence: 99%

Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?

Scaturro

Vitagliani

Tomasello

et al. 2022

JFMK

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Several studies have indicated a correlation between vitamin D deficiency and widespread chronic pain syndromes, such as fibromyalgia. During this study, the effect of supplementation with vitamin D in association with physical exercise in patients with fibromyalgia was evaluated, in terms of improvement of pain, functional capacity and quality of life, also evaluating the presence of any differences in age. A single-center, observational, comparative study was conducted in 80 fibromyalgia patients. They are randomized into 2 groups: Group A, consisting of patients ≤50 years; and group B, consisting of patients >50 years. Both received weekly supplementation with 50,000 IU cholecalciferol for 3 months in association with a rehabilitation protocol. Patients were assessed at enrollment (T0), 3 months (T1), and 6 months (T2) from the initial assessment with blood vitamin D dosage and administration of rating scales (NRS, FIQ, and SF-12). From the comparison between the two groups, we have seen that in young people, supplementation with high-dose vitamin D improves short-term musculoskeletal pain and long-term functional capacity. Conversely, musculoskeletal pain and long-term quality of life improve in the elderly. Supplementing with high doses of vitamin D in fibromyalgia patients improves the quality of life and pain in the elderly and also the functional capacity in the young.

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The effect of vitamin D treatment on quality of life in patients with fibromyalgia

Ersoy,

Kesiktas,

Sirin

et al. 2023

Ir J Med Sci

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Background Fibromyalgia is a syndrome characterized by chronic widespread pain accompanied by fatigue, disrupted sleep quality, cognitive impairments, subjective soft tissue swelling, and somatic symptoms. There are conflicting results in the literature regarding the prevalence of vitamin D deficiency in fibromyalgia patients and the reduction of symptoms after supplementation. Aims Our study aims to evaluate the effectiveness and reliability of vitamin D supplementation in patients diagnosed with fibromyalgia. Methods In our cross-sectional clinical study, 180 female patients aged 18 to 65 diagnosed with fibromyalgia according to the 2010 American College of Rheumatology Diagnostic Criteria were included. Oral vitamin D3 replacement of 50,000 IU was administered for 12 weeks. Patients' Fibromyalgia Impact Questionnaire (FIQ)and Visual Analogue Scale (VAS) scores were evaluated before and after the study. Results Significant differences were observed in the FIQ scores of the 180 fibromyalgia patients before and after vitamin D supplementation (p < 0.05). There was also a significant improvement in VAS scores (p < 0.01). A negative correlation between vitamin D and VAS as well as FIQ scores was found in the study. Conclusion We determined that vitamin D deficiency is significantly more prevalent in patients diagnosed with fibromyalgia. Vitamin D supplementation was observed to have a positive effect on quality of life and reduction of pain.

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Efficacy and safety of weekly vitamin D3 in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial

Cited by 11 publications

References 33 publications

The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?

The effect of vitamin D treatment on quality of life in patients with fibromyalgia

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