Efficacy and safety of Zuojin Pill for chronic gastritis

Abstract

Background: Chronic gastritis (CG), as the highest incidence of gastrointestinal diseases, has been gradually increasing around globally. With the obvious disadvantages of standard treatment, more and more people ask the traditional Chinese medicine for help in the treatment of CG. As a traditional Chinese medicine compound, Zuojin Pill (ZJP) has a long history of clinical application in the treatment of digestive system diseases. Whereas, neither systematic nor meta-analysis of randomized controlled trials explain the efficacy and safety of ZJP in treating CG. Thus, we provide a protocol to evaluate the efficacy and safety of ZJP for CG. Methods: From the beginning to December 2019, the following electronic databases will be searched for studies in English or Chinese: the Cochrane Library, Embase, PubMed, Web of Science, the Chinese National Knowledge Infrastructure, the Chinese Biomedical Literature Database, the Chinese Scientific Journal Database, and the Wanfang Database. Clinical efficiency, helicobacter pylori infection clearance rate, quality of life and symptom scores will be measured as primary outcomes. Meta-analysis will be performed using the Stata 15. Outcomes: This study will provide the current evidence of CG treated with ZJP from the several aspects including clinical efficiency, helicobacter pylori infection clearance rate, quality of life, symptom scores, the 1-year recurrent rate, efficacy under endoscopy and number of reported adverse events associated with the use of ZJP. Conclusion: The outcomes of this review will be served as a proof to evaluate if ZJP is effective in the treatment of CG. PROSPERO registration number: PROSPERO CRD42020155036.

Investigating Molecular Mechanisms Underlying the Therapeutic Effects of Zuo Jin Pill in Ulcerative Colitis: A Combined Approach of Network Pharmacology and Experimental Validation

“…As a representative prescription in traditional Chinese medicine, ZJP exhibits functions such as inhibiting gastric acid secretion and exerting anti-ulcer and antibacterial effects, effectively ameliorating severe gastrointestinal reactions in patients. 8,14,15 Although ZJP holds therapeutic potential for UC, its mechanism remains incompletely elucidated. ZJP has been established to regulate intestinal flora and Treg cells, along with their subsets, and exert anti-oxidative stress effects in the treatment of UC.…”

“…6,7 Esteemed for its safety, efficacy, and prevention of disease recurrence, ZJP has found extensive utility in clinical practice and boasts a clinical therapeutic history spanning over 600 years. 8 Multiple studies have substantiated the efficacy of ZJP in addressing UC 9,10 ; however, the precise mechanistic basis of its therapeutic action in UC remains incompletely elucidated. In recent years, network pharmacology, employing a holistic research paradigm characterized by "multi-component-multi-targetcomplex disease," has provided preliminary insights into the mode of action of traditional Chinese medicine in disease treatment.…”

Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis

“…Recent research studies have shown that ZJP has a good therapeutic effect on gastric ulcer [4], ulcerative colitis [5], and other diseases. A meta-analysis based on a systematic review highlights that ZJP is effective and safe for chronic gastritis [6]. Our previous studies [7] showed that ZJP could ameliorate the injury of GES-1 and MNNG-induced CAG rats.…”