Efficacy and safety profile of cranberry in infants and children with recurrent urinary tract infection

Fernández-Puentes, V.; Uberos, J.; Rodríguez-Belmonte, Rocío; Nogueras-Ocaña, Mercedes; Blanca-Jover, Enrique; Narbona-López, Eduardo

doi:10.1016/j.anpede.2015.05.007

Cited by 6 publications

(8 citation statements)

References 29 publications

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“…Because of the similar infection rates between groups, the authors concluded that cranberry juice was not inferior to trimethoprim in both age groups. 17 Overall, the studies conducted in patients with underlying urogenital abnormalities demonstrated decidedly mixed results for cranberry products compared with the studies performed in otherwise healthy children. Two studies found no benefit with cranberry products compared with placebo, whereas a third found cranberry to have favorable outcomes.…”

Section: Studies In Children With Anatomical Abnormalitiesmentioning

confidence: 94%

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Cranberry Products for the Prophylaxis of Urinary Tract Infections in Pediatric Patients

2015

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Section: Studies In Children With Anatomical Abnormalitiesmentioning

confidence: 94%

“…Because of the similar infection rates between groups, the authors concluded that cranberry juice was not inferior to trimethoprim in both age groups. 17…”

Section: Studies In Children With Anatomical Abnormalitiesmentioning

confidence: 99%

Cranberry Products for the Prophylaxis of Urinary Tract Infections in Pediatric Patients

2015

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“…The use of cranberry has been confirmed to be safe in both infants and children ( Fernández-Puentes et al, 2015 ). Several clinical trials that explored the effects of cranberry supplementation among pediatric patients have demonstrated reduced UTI incidence in children with recurrent episodes, both male and female ( Ferrara et al, 2009 ; Afshar et al, 2012 ; Mutlu and Ekinci 2012 ; Salo et al, 2012 ; Fernández-Puentes et al, 2015 ; Wan et al, 2016 ).…”

Section: Complementary Medicine For Treating Urinary Tract Infections...mentioning

confidence: 99%

Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children

et al. 2022

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Urinary tract infections (UTIs) are a significant clinical problem that pregnant women and children commonly experience. Escherichia coli is the primary causative organism, along with several other gram-negative and gram-positive bacteria. Antimicrobial drugs are commonly prescribed to treat UTIs in these patients. Conventional treatment can range from using broad-spectrum antimicrobial drugs for empirical or prophylactic therapy or patient-tailored therapy based on urinary cultures and sensitivity to prospective antibiotics. The ongoing emergence of multi-drug resistant pathogens has raised concerns related to commonly prescribed antimicrobial drugs such as those used routinely to treat UTIs. Consequently, several natural medicines have been explored as potential complementary therapies to improve health outcomes in patients with UTIs. This review discusses the effectiveness of commonly used natural products such as cranberry juice/extracts, ascorbic acid, hyaluronic acid, probiotics, and multi-component formulations intended to treat and prevent UTIs. The combination of natural products with prescribed antimicrobial treatments and use of formulations that contained high amounts of cranberry extracts appear to be most effective in preventing recurrent UTIs (RUTIs). The incorporation of natural products like cranberry, hyaluronic acid, ascorbic acid, probiotics, Canephron® N, and Cystenium II to conventional treatments of acute UTIs or as a prophylactic regimen for treatment RUTIs can benefit both pregnant women and children. Limited information is available on the safety of natural products in these patients’ populations. However, based on limited historical information, these remedies appear to be safe and well-tolerated by patients.

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“…Long-term antibiotics like trimethoprim are an effective way to prevent UTI and three trials have studied cranberry products in head-to-head comparisons with them. 40,61,62 In two trials, more UTI had occurred in the cranberry-treated patients than in antibiotic-treated patients. 40,61 In defend of the failure, underdosing of cranberry bioactivity had been discussed also for these studies.…”

mentioning

confidence: 99%

“…In a third small trial performed in children, cranberry had not been inferior to trimethoprim. 62 Another widely discussed advantage of cranberry products over antibiotics is their anti-biofilm efficacy, which had been documented in vitro. 63,64 Biofilms are breeding grounds for bacteria, including multi-resistant strains, and a source for recurrent UTI, eg, in patients with neuropathic bladder dysfunction with indwelling catheters.…”

mentioning

confidence: 99%

Cranberry products in the prevention of urinary tract infections: examining the evidence

Nowack¹,

Birck²

2015

BTAT

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Cranberry (Vaccinium macrocarpon) juice and extracts are widely used and recommended as folk remedy for prophylaxis of urinary tract infections (UTIs). Its putative mechanism is an anti-adhesive effect that prevents docking of bacteria on host tissues. The antiadhesion quality is attributed to A-type proanthocyanidins (PACs), a group of polyphenols that has a restricted occurrence in cranberries and a few related plants. Clinical trials with cranberry have provided a mixed evidence on behalf of UTI prophylaxis. In some trials, a benefit could not be detected due to lower than calculated UTI recurrence rates, in others failure had retrospectively been blamed on underdosing of cranberry products. To circumvent such problems, cranberry products need to be standardized for the bioactive principle of PAC and administered at a sufficient dose. Further characterization of PAC bioavailability, improvement of the currently inconvenient prescriptions, and above all of the palatability for patients is strongly recommended. Larger staged trials should then be carried out in patients with relevant UTI risks.

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Efficacy and safety profile of cranberry in infants and children with recurrent urinary tract infection

Cited by 6 publications

References 29 publications

Cranberry Products for the Prophylaxis of Urinary Tract Infections in Pediatric Patients

Cranberry Products for the Prophylaxis of Urinary Tract Infections in Pediatric Patients

Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children

Cranberry products in the prevention of urinary tract infections: examining the evidence

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