Efficacy and Stability of Scorpion Antivenom: At Different Storage Conditions

Abstract

The aim of this study was to investigate the efficacy and stability of scorpion antivenom brand. Several tests were applied on scorpion antivenom samples obtained from the same batch. The samples were subdivided into two groups. The first group was stored at real storage conditions i.e. at (3 ± 2ºC) dry storage areas while the second group was subjected to accelerated storage conditions i.e. (25 ± 3ºC, RH75%). Many samples taken from both conditions were tested chemically through determining the pH values, m-cresol preservative levels, albumin content by polyacryl amide gel electrophoresis (PAGE) and measuring the protein content. These samples were also tested pharmacologically for determining the potency, measuring the LD50 (lethal dose which kills 50% of the test animals), pyrogen testing, sterility testing and abnormal toxicity. The results obtained from both chemical and pharmacological tests using antivenom samples stored at real time storage condition (3 ± 2ºC) and accelerated storage condition (25 ± 3ºC, RH75%) showed no significant changes in terms of potency, pH values, sterility, preservative content, the pharmacological effect and efficacy.

Design and analysis of a solar‐powered refrigeration system with thermal energy storage for efficient storage of scorpion antivenom

“…Increasing the amount of saltwater solution allowed the fridge to absorb more heat. Case 3 achieved a final temperature of 6°C, Case 4 reached 5.5°C, and Case 5 maintained a temperature of 4°C, which is suitable for storing antivenom as recommended by 4 . The relationship between the outside temperature and the inside fridge temperature in Case 5 is illustrated in Figure 6.…”

“…Case 3 achieved a final temperature of 6 C, Case 4 reached 5.5 C, and Case 5 maintained a temperature of 4 C, which is suitable for storing antivenom as recommended by. 4 The relationship between the outside temperature and the inside fridge temperature in Case 5 is illustrated in Figure 6. All the experiments were conducted at the typical temperature found in the northern state of Sudan.…”

“…The recommended storage condition is (3 ± 2 C). 4 The objective of this paper is to design and investigate a solar-powered refrigeration system utilizing saltwater as a thermal storage system. The study aims to determine the optimal salt concentration and the required amount of the solution.…”

“…This paper aims to investigate solar‐powered refrigeration technologies tailored to the Sahara region, with a specific emphasis on preserving scorpion antivenom. The recommended storage condition is (3 ± 2°C) 4 . The objective of this paper is to design and investigate a solar‐powered refrigeration system utilizing saltwater as a thermal storage system.…”