Efficacy and Thermal Safety of Tumor Treating Fields Delivered to the Thorax: A Simulation-Based Study

Bomzon, Zéev; Urman, Noa; Naveh, Ariel; Hershkovich, Hadas Sara; Weinberg, Uri; Kirson, Eilon D.

doi:10.1016/j.ijrobp.2019.06.1376

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(7) Computational models of the abdomen and thorax have also shown > 1 V/cm of electric field intensity with TTFields. (8)(9)(10) In vivo studies have confirmed >1V/cm deliver of electric fields to the thorax. (11)…”

Section: Characteristics Of Ttfieldsmentioning

confidence: 96%

“…Studies using 3D shaped head models show that although electric field distribution is heterogeneous, large portions of the brain receive a dose greater than 1 V/cm ( 7 ). Computational models of the abdomen and thorax have also shown > 1 V/cm of electric field intensity with TTFields ( 8–10 ). In vivo studies have confirmed >1V/cm deliver of electric fields to the thorax ( 11 ).…”

Section: Characteristics Of Ttfieldsmentioning

confidence: 99%

See 1 more Smart Citation

The Mechanisms of Action of Tumor Treating Fields

et al. 2022

View full text Add to dashboard Cite

Tumor Treating Fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While anti-mitotic effects were the first recognized biological anti-cancer activity of TTFields, data have shown that tumor treating fields achieve their anti-cancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.

show abstract