Efficacy and Tolerability of a Fluid Extract Combination of Thyme Herb and Ivy Leaves and Matched Placebo in Adults Suffering from Acute Bronchitis with Productive Cough

Abstract

Oral treatment of acute bronchitis with thyme-ivy combination for about 11 days was superior to pla-

Spicae aetheroleum in uncomplicated acute bronchitis: a double-blind, randomised clinical trial

“…The validation of the used parameter BSS is based on several studies on acute bronchitis [21,22,25,33,34]. The baseline BSS in our study was comparable to the severity of illness as reflected in the baseline BSS from other interventional studies [22,25,26,34]. Therefore, we assume that the patients who participated in our study constitute a representative sample of the patient collective suffering from acute bronchitis; thus the external validity of our study can be deduced.…”

“…Several clinical studies showed improved symptom relief in adults suffering from acute bronchitis with plant preparations containing 1,8-cineole and/or linalool when compared to placebo [20][21][22][23][24][25][26]. Spike lavender essential oil (Spicae aetheroleum, Spicae ae.)…”

“…A study conducted by Kemmerich et al treated 361 patients suffering from acute bronchitis and revealed superiority (p < 0.0001) with a thyme herb and ivy leaves combination compared to placebo with regard to reduction of the frequency of coughing fits [26]. The regression of symptoms was faster and the responder rates compared to placebo were significantly higher when treated with the thyme-ivy combination.…”

The BSS - A Valid Clinical Instrument to Measure the Severity of Acute Bronchitis

“…[18][19][20][21][22][23][24][25][26][27][28][29] Recently, a review of all trials employing the BSS until April 2012 was published. 30 Moreover, Kardos and colleagues reported of the BSS as a current example for the use of a composite scale.…”

“…Finally, the BSS was brought to the notice of the international scientific community by over a dozen publications [13][14][15][16][17][19][20][21][22][23][24][25][26][27][28][29]34 and it was not rejected. All these arguments speak for a high content validity of the BSS.…”