Efficacy and tolerability of a novel herbal formulation for weight management

Stern, Jennifer; Peerson, Janet M; Mishra, A.T.; Rao, Meghana; Rajeswari, K

doi:10.1002/oby.20211

Cited by 27 publications

(36 citation statements)

References 31 publications

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“…Sphaeranthus indicus (East India globe thistle) combined with Garcinia mangostana (mangosteen) was examined in two studies (n = 120) conducted by two different research groups in India . Daily dosages were 600 mg of S. indicus and 200 mg of G. mangostana taken over 8 and 16 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…One study was rated at low risk of selection bias, attrition bias and other biases; however, had a high risk of detection bias as unblinding occurred prior to data analysis . The other study was rated as having a low risk of attrition bias and reporting bias but could not be assessed for the other criteria because of inadequate reporting . Both studies reported statistically and clinically significant weight differences of −3.7 kg and − 4.0 kg compared to placebo.…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Maunder

Bessell

Lauche

et al. 2020

Diabetes Obesity Metabolism

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Aim: To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and metaanalysis of herbal medicines for weight loss.Methods: Four electronic databases (Medline, Embase, CINAHL and Web of Science) were searched from inception until August 2018. A total of 54 randomized placebocontrolled trials of healthy overweight or obese adults were identified. Meta-analyses were conducted for herbal medicines with ≥4 studies available. Weight differences of ≥2.5 kg were considered clinically significant.Results: As a single agent, only Phaseolus vulgaris resulted in a statistically significant weight loss compared to placebo, although this was not considered clinically significant. No effect was seen for Camellia sinensis or Garcinia cambogia. Statistically, but not clinically, significant differences were observed for combination preparations containing C. sinensis, P. vulgaris or Ephedra sinica. Of the herbal medicines trialled in ≤3 randomized controlled trials, statistically and clinically significant weight loss compared to placebo was reported for Irvingia gabonensis, Cissus quadrangularis, and Sphaeranthus indicus combined with Garcinia mangostana, among others, but these findings should be interpreted cautiously because of the small number of studies, generally poor methodological quality, and poor reporting of the herbal medicine interventions. Most herbal medicines appeared safe for consumption over the short duration of the studies (commonly ≤12 weeks). Some warrant further investigation to determine effect size, dosage and long-term safety.Conclusion: There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review. K E Y W O R D Sherbal medicines, meta-analysis, systematic review, weight loss

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Maunder

Bessell

Lauche

et al. 2020

Diabetes Obesity Metabolism

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“…Statistical significance was set at ≤0.05. Power calculations, using previously published efficacy data [5, 6], allowed us to conclude that 20 completers per cohort was sufficient to achieve 80 % power to detect outcome differences in weight loss between the groups, assuming a two-sided significance level of 0.05. Thirty subjects per treatment group were calculated to provide more than 90 % power under identical analytical conditions.…”

Section: Methodsmentioning

confidence: 99%

“…Earlier studies reported that an herbal formulation (Meratrim) consisting of extracts of the flower heads from Sphaeranthus indicus and the fruit rinds of Garcinia mangostana demonstrated significant weight loss outcomes in two randomized, double-blind, placebo-controlled clinical studies on obese subjects [5, 6]. An 800 mg daily dose of this supplement resulted in statistically significant reductions in body weight, BMI, waist and hip circumference that exceed those achieved via diet and exercise alone.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects

Venkateshwarlu¹,

Kodur²,

Kodur³

et al. 2016

Lipids Health Dis

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BackgroundMeratrim is a blend of two plant extracts obtained from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects.MethodsSixty participants with a mean BMI of 28.3 kg/m2 were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks. Subjects were asked to consume about 2,000 kcal/day throughout the study period and walk 5 days a week for 30 min daily. The primary endpoint was defined as the change in body weight from baseline to end of week 16 for the Meratrim group versus placebo. Fifty seven subjects completed the trial.ResultsAt study conclusion, statistically significant reductions in body weight (5.09 vs. 1.1 kg; p < 0.0001), BMI (1.91 vs. 0.43 kg/m2; p < 0.0001), waist (9.97 vs. 3.71 cm; p < 0.001) and hip size (10.38 vs. 5.11 cm; p < 0.0001) were observed in the Meratrim versus the placebo group. Additionally, a significant change in serum LDL (−14.79 vs. 6.25 mg/dL; p < 0.0001), triglycerides (−43.62 vs. -13.68 mg/dL; p < 0.001) and total cholesterol (−20.0 vs. -0.75 mg/dL; p = 0.0002) was observed in the Meratrim cohort compared to the placebo. No supplementation related adverse events were noted during the study.ConclusionsThe study findings suggest that Meratrim is well-tolerated and is an effective ingredient for weight management in healthy overweight subjects.Trial registrationCTRI/2014/07/004727; www.CTRI.nic.in

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“…Also, some adverse effects such as headache, nausea, gastrointestinal irritation, plus back, leg, ankle, and joint pain were associated with the combination use of S. indicus and G. mangostana (Stern, Peerson, Mishra, Sadasiva Rao, & Rajeswari, 2013).…”

Section: Adverse Effectsmentioning

confidence: 99%

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

104

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Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta‐analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: −0.75 [−1.18, −0.319]), body mass index ([SMD]: −1.2 [−1.82, −0.57]), waist circumference ([SMD]: −1.71 [−2.66, −0.77]), hip circumference ([SMD]: −0.42 [−1.02, −0.19]), and total cholesterol, ([SMD]: −0.43 [−0.77, −0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: −0.88, 95 % CI: [−1.13, −0.63]) and triglyceride ([SMD]: −1.67, 95 % CI: [−2.54, −0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.

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Efficacy and tolerability of a novel herbal formulation for weight management

Cited by 27 publications

References 31 publications

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

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