Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study

Comparative study between topical clindamycin solution (1%) versus combination of clindamycin (1%)/adapalene (0.1%) gel in the treatment of mild to moderate acne vulgaris

“…The present study revealed a statistically significant reduction of TLC (P = 0.008) and NIL (P = 0.002) from the baseline in group II than in group I (due to the comedolytic activity of adapalene in the combination gel). These two findings were compatible with the findings obtained from a previous study, 10 which revealed a significantly greater reduction of total (P <0.001), and non-inflammatory lesions (P <0.001) in clindamycin plus adapalene group than in the clindamycin plus vehicle group at week 12. The findings in the present study were also comparable with the findings obtained from a 2-phase, 24-week, multicenter, randomized, investigator-blind study performed by Zhang et al in 2004, which evaluated the efficacy and safety of adapalene 0.1% gel plus clindamycin topical 1% solution versus clindamycin topical 1% solution alone during the initial 12-week phase of treatment, and revealed a statistically significant greater reduction in total lesion counts from week four until week 12, and from week eight on for non-inflammatory lesion count (P <0.05) for the combination therapy compared with monotherapy.…”

Frequency of Primary Nonadherence to Acne Treatment

“…Not all patients who were called gave consent because some patients did not answer the call after 3 attempts or declined to participate. A total of 40 males and 103 females gave consent to participate (mean [SD] age, 28 [14] years).…”

Observational study to see efficacy and Safety profile of Benzoyl peroxide 2.5%, Adapalene 0.1% and its fixed dose combination in mild to moderate grade of Acne Vulgaris

“…Due to its complex pathogenesis, the multifactorial effects are demanded from acne therapy for which often combination therapy is recommended. [15][16] Combination therapy like benzoyl peroxide and adapalene is a rare and very effective combination as benzoyl peroxide is lipophilic and when applied to the skin it is capable of penetrating into the pilosebaceous follicle. Within the skin, benzoyl peroxide releases free radical oxygen and benzoic acid.…”