2003
DOI: 10.1016/s0090-4295(02)02114-3
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Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial

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Cited by 334 publications
(261 citation statements)
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“…Previous studies with other a 1 -AR antagonists, such as the Veterans Affairs (VA), ALFIN and Prospective European Doxazosin and Combination Therapy (PREDICT) trials, failed to demonstrate additional efficacy with the combination of these two classes of drugs. [10][11][12] Therefore, at variance with the design of the mentioned studies, a combination arm was not included in the MICTUS study. Owing to the low acceptance by European investigators, patients and Ethical Committees of a long-term study with placebo and in line with the European study comparing alfuzosin and finasteride, a placebo group was also not included.…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies with other a 1 -AR antagonists, such as the Veterans Affairs (VA), ALFIN and Prospective European Doxazosin and Combination Therapy (PREDICT) trials, failed to demonstrate additional efficacy with the combination of these two classes of drugs. [10][11][12] Therefore, at variance with the design of the mentioned studies, a combination arm was not included in the MICTUS study. Owing to the low acceptance by European investigators, patients and Ethical Committees of a long-term study with placebo and in line with the European study comparing alfuzosin and finasteride, a placebo group was also not included.…”
Section: Discussionmentioning
confidence: 99%
“…20 As already indicated, our study did not include a combination arm of tamsulosin and finasteride as the VA, ALFIN and PREDICT study did not show an advantage of this treatment over monotherapy with an a 1 -AR antagonist after up to 1 y of treatment. [10][11][12] Recently, the results of the landmark Medical Therapy Of Prostatic Symptoms (MTOPS) trial, a placebo-controlled study comparing the a 1 -AR antagonist doxazosin, finasteride and their combination in 3047 LUTS/BPH patients with a mean follow-up of 5 y, became available. 21,22 These results indicate that, in the long term, combination therapy is statistically significantly more effective than both monotherapies, in improving urinary symptoms (total I-PSS) and reducing clinical progression.…”
Section: Discussionmentioning
confidence: 99%
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“…[58,59] In these trials, a combination of finasteride and terazosin and that of finasteride and doxazosin were evaluated in BPH patients over a period of 12 months. In both the trials, the combination therapy was found to be no more effective than the use of alpha-adrenergic blockers alone.…”
Section: Combination Of 5α-reductase Inhibitors and Alpha-adrenergic mentioning
confidence: 99%
“…Bu durum kombine tedavi arayışlarını arttırmıştır. 1990'lı yıllara kadar 5 alfa redüktaz inhibitörlerinin alfa blokör tedavi ile kombinasyonun monoterapiye belirgin bir üstünlüğünün olmadığı belirtilirken daha sonra yapılan önemli bazı çalışmalardan sonra günümüzde AUA ve EAU klavuzlarında önerilen bir tedavi halini almıştır (13).…”
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