Efficacy and tolerability of low‐volume (2 L) versus single‐ (4 L) versus split‐dose (2 L + 2 L) polyethylene glycol bowel preparation for colonoscopy: Randomized clinical trial

Téllez-Ávila, Félix Ignacio; Murcio-Pérez, Enrique; Saúl, Ángela; Herrera-Gómez, Salvador; Valdovinos-Andraca, Francisco; Acosta-Nava, Víctor Manuel; Barreto, Rafael Ferreira; Elizondo-Rivera, Javier

doi:10.1111/den.12265

Cited by 30 publications

(27 citation statements)

References 20 publications

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“…Thus, adequate bowel preparation for colonoscopy remains a practical concern in the elderly population. Previous studies have consistently reported that split-dose PEG is superior to single-dose PEG with respect to the coloncleansing quality and tolerability [4,17,21,[24][25][26][27][28] . A recent meta-analysis evaluating 7,719 subjects in 29 studies also showed the superiority of a split-dose regimen over a non-split-dose regimen, regardless of purgative type or dose [5] .…”

Section: Discussionmentioning

confidence: 99%

“…A sample-size calculation was carried out based on previously published data, indicating a good to excellent preparation in 90% of patients receiving split-dose PEG preparation and in 70% of patients receiving single-dose PEG (4 L) preparation the day before colonoscopy [21] . To achieve an absolute difference of 20% in the frequency of good to excellent quality of cleansing in the colon (score ≥ 2) with a statistical type I error of 5% and a statistical power of 80%, a total of 186 participants (62 participants per group) was calculated to be required.…”

Section: Outcome Measurements and Statistical Analysismentioning

confidence: 99%

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Low-Volume Polyethylene Glycol with Ascorbic Acid for Colonoscopy Preparation in Elderly Patients: A Randomized Multicenter Study

et al. 2016

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Background: Minimal data exist regarding the use of low-volume purgatives for elderly (≥65 years) patients. We aimed to investigate the bowel-cleansing efficacy and patient tolerability of split-dose 2 liters (L)-polyethylene glycol with ascorbic acid (2L-PEGA) in elderly outpatients undergoing colonoscopy. Methods: Patients who underwent morning colonoscopies were randomly assigned to one of 3 arms: single-dose 4L-PEG on the day before colonoscopy; split-dose 4L-PEG; or split-dose 2L-PEGA. The quality of bowel preparation was assessed using the Boston Bowel Preparation Scale (BBPS). Results: Of 230 patients enrolled, 198 were analyzed. The proportion of adequate bowel preparations in split-dose 2L-PEGA was higher than that in single-dose 4L-PEG (92.1 vs. 75.0%, p = 0.009) and similar to split-dose 4L-PEG. The mean BBPS scores for global and right colon preparation in the split-dose 2L-PEGA were comparable to split-dose 4L-PEG but higher than those in the single-dose 4L-PEG. The proportion of patients who ingested the entire volume of solution in 2L-PEGA was higher than that in single-dose 4L-PEG (96.8 vs. 80.9%, p = 0.011). Patients receiving 2L-PEGA expressed more willingness to repeat the same preparation than other groups. The rate of adverse events did not differ among the 3 groups. Conclusions: Split-dose 2L-PEGA was an effective, safe, and comfortable method for colonoscopy preparation in elderly outpatients.

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Section: Discussionmentioning

confidence: 99%

Section: Outcome Measurements and Statistical Analysismentioning

confidence: 99%

Low-Volume Polyethylene Glycol with Ascorbic Acid for Colonoscopy Preparation in Elderly Patients: A Randomized Multicenter Study

et al. 2016

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“…In recent studies [21][22][23], low-volume bowel preparations have shown improved tolerability and successful bowel cleansing compared with large-volume (4-L) PEG preparations. However, few reports have compared SPMC and PEG-Asc, which are representative low-volume bowel preparations.…”

Section: Discussionmentioning

confidence: 99%

A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy

Yoo¹,

Lee²,

Chun

et al. 2015

Digestive and Liver Disease

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“…Interestingly, recently published study using 2-liter PEG without any adjunctive laxative in the morning of the procedure date, together with keeping 2-7h interval between the last dose of cleansing agent and colonoscopy resulted in a similar bowel preparation quality compared to standard split-dose 4-liter PEG regimen (Tellez-Avila FI et al, 2014). These can be concluded that time interval between last dose of cleansing agent and procedure is more important than volume of PEG ingested.…”

Section: Discussionmentioning

confidence: 95%

Incidence and Predictors of Inadequate Bowel Preparation before Elective Colonoscopy in Thai Patients

Bhanthumkomol

Siramolpiwat²,

Vilaichone³

2015

Asian Pacific Journal of Cancer Prevention

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Background: The incidence of inadequate bowel preparation before elective colonoscopy in this region has never been studied. Materials and Methods: The authors prospectively described the incidence and factors related to inadequate bowel preparation in Thammasat university hospital. Bowel preparation quality was accessed by using Aronchick scale. Factors associated with inadequate bowel preparation were also recorded. Results: Two hundred patients undergoing elective outpatient colonoscopy were enrolled. Inadequate and fair bowel preparation was documented in 9 and 43%, respectively. Factors associated with inadequate bowel preparation were incomplete cleansing agent ingestion (odds ratio 7.7; 95%CI 1.62-36.64) and patient's unrecognization of vegetable avoidance (odds ratio 3.26; 95%CI 1.14-9.28). Conclusions: Compared with previous reported, inadequate bowel preparation was seen less in our study, however, more patients with fair bowel preparation was documented. Further study aiming at investigating the type and amount of fiber contained in diet before elective colonoscopy should be commenced.

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Efficacy and tolerability of low‐volume (2 L) versus single‐ (4 L) versus split‐dose (2 L + 2 L) polyethylene glycol bowel preparation for colonoscopy: Randomized clinical trial

Abstract: Preparation with 2 L caused less abdominal discomfort and fewer sleep disorders. The split dose had a better quality of preparation in the right colon. Both preparations were clearly better than the 4-L preparation.

Cited by 30 publications

References 20 publications

Low-Volume Polyethylene Glycol with Ascorbic Acid for Colonoscopy Preparation in Elderly Patients: A Randomized Multicenter Study

Low-Volume Polyethylene Glycol with Ascorbic Acid for Colonoscopy Preparation in Elderly Patients: A Randomized Multicenter Study

A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy

Incidence and Predictors of Inadequate Bowel Preparation before Elective Colonoscopy in Thai Patients

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