Efficacy and tolerability of pregabalin in essential tremor: A randomized, double-blind, placebo-controlled, crossover trial

Ferrara, Joseph M.; Kenney, C.; Davidson, Anthony; Shinawi, Lina; Kissel, Abigail M.; Jankovic, Joseph

doi:10.1016/j.jns.2009.06.044

Cited by 42 publications

(23 citation statements)

References 9 publications

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“…Similarly, pregabaline [63,64] (doses up to 600 mg/day) and progabide [65] (at 1800 mg/day and 3600 mg/day), as well as amantadine (dose: 200 mg/day) [66] failed to produce significant benefit. Likewise, the antidepressants trazodone (dose: 100 mg/day), a serotonine reuptake inhibitor [67], and mirtazapine (dose: 45 mg/day) [68] showed no significant results.…”

Section: Likely Not Efficacious Drugsmentioning

confidence: 99%

The Treatment of Tremor

Schneider

Deuschl

2014

Neurotherapeutics

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Tremor is a hyperkinetic movement disorder characterized by rhythmic oscillations of one or more body parts. It can be disabling and may impair quality of life. Various etiological subtypes of tremor are recognized, with essential tremor (ET) and Parkinsonian tremor being the most common. Here we review the current literature on tremor treatment regarding ET and head and voice tremor, as well as dystonic tremor, orthostatic tremor, tremor due to multiple sclerosis (MS) or lesions in the brainstem or thalamus, neuropathic tremor, and functional (psychogenic) tremor, and summarize main findings. Most studies are available for ET and only few studies specifically focused on other tremor forms. Controlled trials outside ET are rare and hence most of the recommendations are based on a low level of evidence. For ET, propranolol and primidone are considered drugs of first choice with a mean effect size of approximately 50 % tremor reduction. The efficacy of topiramate is also supported by a large double-blind placebocontrolled trial, while other drugs have less supporting evidence. With a mean effect size of about 90 % deep brain stimulation in the nucleus ventralis intermedius or the subthalamic nucleus may be the most potent treatment; however, there are no controlled trials and it is reserved for severely affected patients. Dystonic limb tremor may respond to anticholinergics. Botulinum toxin improves head and voice tremor. Gabapentin and clonazepam are often recommended for orthostatic tremor. MS tremor responds only poorly to drug treatment. For patients with severe MS tremor, thalamic deep brain stimulation has been recommended. Patients with functional tremor may benefit from antidepressants and are best be treated in a multidisciplinary setting. Several tremor syndromes can already be treated with success. But new drugs specifically designed for tremor treatment are needed. ET is most likely covering different entities and their delineation may also improve treatment. Modern study designs and long-term studies are needed.

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Section: Likely Not Efficacious Drugsmentioning

confidence: 99%

The Treatment of Tremor

Schneider

Deuschl

2014

Neurotherapeutics

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“…The authors found significant improvement in accelerometry and tremor clinical scores. However, 2 years later, Ferrara et al51 performed another controlled study with pregabalin in 20 ET patients with a titration period of 6 weeks and found no improvement in any of the tremor measures.…”

Section: Introductionmentioning

confidence: 99%

The GABA Hypothesis in Essential Tremor: Lights and Shadows

Gironell

2014

Tremor and Other Hyperkinetic Movements

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“…Their series did, however, consist of newly diagnosed patients and patients with probable ET. The QUEST-SI score was slightly higher, indicating slightly better quality of life, than in the literature in general [48]. The significance of this is difficult to evaluate, however, due to the small number of publications using QUEST.…”

Section: Side Effectsmentioning

confidence: 57%

Thalamotomy for Essential Tremor: A Very Long-Term Follow-Up

Sandvik¹,

Rosendal²,

Doorn³

et al. 2014

TONEUROSJ

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Abstract:Background: DBS (deep brain stimulation) is currently the golden standard in the surgical treatment of ET (essential tremor). Despite the benefits of DBS, there remain situations where lesional surgery may provide an alternative.Objective: To perform a very long-term retrospective evaluation of thalamotomies for ET.Methods: Nine patients who underwent thalamotomy for ET during 1972-1999 (follow-up period 20.8±5.2 years) were assessed with regard to tremor scores, side effects, and quality of life, as well as lesion size and location.Results: All patients had tremor recurrence, although handfunction remained slightly better on the treated side than on the non-treated side. Side effects that could be attributed to the procedure were frequent and did in some cases result in a disability for the patient. Quality of life was poorer in this group than in an age-adjusted healthy population. No correlation between lesion size, location, and long-term outcome could be established. Conclusions:In this study population the benefits of thalamotomies were limited, while complications were frequent.

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Efficacy and tolerability of pregabalin in essential tremor: A randomized, double-blind, placebo-controlled, crossover trial

Cited by 42 publications

References 9 publications

The Treatment of Tremor

The Treatment of Tremor

The GABA Hypothesis in Essential Tremor: Lights and Shadows

Thalamotomy for Essential Tremor: A Very Long-Term Follow-Up

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