Efficacy and Tolerability of Zuranolone in Patients with Depression: A Meta-analysis of Randomized controlled trials

Abstract

Review question / Objective: (a) population: patients diagnosed as major depressive disorder or postpartum depression according to standard diagnostic criteria; ( b ) i n t e r v e n t i o n : p a t i e n t s re c e i v e d zuranolone were considered intervention group; (c) comparison: patients received placebo were considered comparsion group; (d) outcome: the primary outcome was the change of depressive severity scores. Secondary efficacy outcomes included response and remission after the treatment; safety outcomes were adverse events; (e) study design: only randomized controlled trials were included. Condition being studied: Depression is a c h ro n i c m e n t a l d i s o rd e r w i t h h i g h prevalence, which may also result in INPLASY 1