Efficacy comparison of Accell Evo3 and Grafton demineralized bone matrix putties against autologous bone in a rat posterolateral spine fusion model

Brecevich, Antonio T.; Kiely, Paul D.; Yoon, Byung-Jo Victor; Nguyen, Joseph; Cammisa, Frank P.; Abjornson, Celeste

doi:10.1016/j.spinee.2017.01.012

Cited by 18 publications

(8 citation statements)

References 21 publications

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“…Several animal/human cohort studies recognized no significant differences between the performance of allografts and autografts 20–22 . Commercial demineralized bone matrix (DBM) allografts, such as Accell Evo3® and Grafton® exhibited higher rates of posterolateral spinal fusion than iliac crest autografts in a rat study 23 . Similar observations were found in a sheep study 24 .…”

Section: Classificationmentioning

confidence: 70%

“…The differences in the outcomes of studies using similar materials could be due to the different animal models used, the various treatment sites, the sample sizes, expertise, and techniques used for observations (histological stains used and the use of micro‐CT, etc.). Accell®, Evo3®, and Grafton® also performed better than autografts in a spinal fusion study 23 . Other scaffolds such as ArcGel®, 158 mPEG/PLGA hydrogel with BMP‐2, 56 HCCP polymer, 57 Bio‐Oss®, 58 zirconia/HAp composites, 54 and porous HAp scaffolds 81 behaved similarly to autografts in the animal models.…”

Section: Discussionmentioning

confidence: 89%

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A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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Section: Classificationmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 89%

A novel classification of bone graft materials

2022

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“…Rats are lower cost, facilitate shorter operation times and higherthroughput studies, and most importantly, enable more in-depth analyses of the biology underlying fusion due to a wider availability of cellular and molecular tools. Various fusion therapies have been studied in rat models, including: a range of bone graft substitute and extension materials; systemic and localized delivery of osteogenic growth factors and/or osteoporosis therapies; and, stem cell transplantation therapies [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Comparing the Efficacy of Syngeneic Iliac and Femoral Allografts with Iliac Crest Autograft in a Rat Model of Lumbar Spinal Fusion

Holmes

Elder

Ishida

et al. 2020

Preprint

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Background: Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion.Methods: Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft; syngeneic iliac crest allograft; and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources.Results: Although no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow. Conclusions: This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

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“…Rats are lower cost, facilitate shorter operation times and higher-throughput studies, and most importantly, enable more in-depth analyses of the biology underlying fusion due to a wider availability of cellular and molecular tools. Various fusion therapies have been studied in rat models, including a range of bone graft substitute and extension materials, systemic and localized delivery of osteogenic growth factors and/or osteoporosis therapies, and stem cell transplantation therapies [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

et al. 2020

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Background Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion. Methods Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft, syngeneic iliac crest allograft, and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation, and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources. Results Although no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow. Conclusions This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

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Efficacy comparison of Accell Evo3 and Grafton demineralized bone matrix putties against autologous bone in a rat posterolateral spine fusion model

Cited by 18 publications

References 21 publications

A novel classification of bone graft materials

A novel classification of bone graft materials

Comparing the Efficacy of Syngeneic Iliac and Femoral Allografts with Iliac Crest Autograft in a Rat Model of Lumbar Spinal Fusion

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

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