Efficacy Evaluation for Depression with Somatic Symptoms Treated by Electroacupuncture Combined with Fluoxetine

Duan, Dongmei; Tu, Ya; Li-ping, Chen; Wu, Zhengjun

doi:10.1016/s0254-6272(09)60057-1

Cited by 28 publications

(36 citation statements)

References 17 publications

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“…Based on the basic theory of TCM, acupoint compatibility plays an important role in the acupuncture prescription, which in turn is directly involved in the therapeutic effect clinically. During our previous studies, the underlying effects and mechanisms of acupuncture on depression have been investigated [46, 47]. Baihui (GV 20) and Yintang (GV 29) are considered to be the optimized acupoint modules in the treatment of depression [46, 47].…”

Section: Discussionmentioning

confidence: 99%

“…During our previous studies, the underlying effects and mechanisms of acupuncture on depression have been investigated [46, 47]. Baihui (GV 20) and Yintang (GV 29) are considered to be the optimized acupoint modules in the treatment of depression [46, 47]. According to the basic theory of TCM, Baihui (GV 20) and Yintang (GV 29) are acupoints pertaining to the governor meridian, which has a direct contact with the brain through channels and collaterals [48, 49].…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, acupuncture at these acupoint modules can dredge channels and regulate the flow of Qi and the blood of the governor meridian, which in turn regulates mentality and alleviates depression [48–50]. Data from clinical investigations and laboratory animals have provided evidence that acupuncture exhibited antidepressant-like efficacy on depression [47, 51, 52]. Our previous studies have investigated that acupunctured at Baihui (GV 20) and Yintang (EX-HN 3) could well alleviate depression by increasing the expression of excitatory neurotransmitter in the hippocampus, attenuating impaired neurogenesis and inhibiting the apoptosis of hippocampal neurons [46, 47].…”

Section: Discussionmentioning

confidence: 99%

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Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

et al. 2017

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Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms associated with antidepressant response of acupuncture, neurogenesis, and depressive-like behaviors ameliorating remain unexplored. The objective was to identify the mechanisms underlying the antidepressant response of acupuncture through PKA signaling pathway in depression rats by employing the PKA signaling pathway inhibitor H89 in in vivo experiments. Our results indicated that the expression of hippocampal PKA-α and p-CREB was significantly downregulated by chronic unpredicted mild stress (CUMS) procedures. Importantly, acupuncture reversed the downregulation of PKA-α and p-CREB. The expression of PKA-α was upregulated by fluoxetine, but not p-CREB. No significant difference was found between Acu and FLX groups on the expression of PKA-α and p-CREB. Interestingly, H89 inhibited the effects of acupuncture or fluoxetine on upregulating the expression of p-CREB, but not PKA-α. There was no significant difference in expression of CREB among the groups. Conclusively, our findings further support the hypothesis that acupuncture could ameliorate depressive-like behaviors by regulating PKA/CREB signaling pathway, which might be mainly mediated by regulating the phosphorylation level of CREB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

et al. 2017

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“…Our previous studies have demonstrated that EA has the antidepressant-like effect in chronic unpredictable mild stress (CUMS) rats and depressed patients [15–17], and our preliminary studies showed that EA treatment improved 5-HT level. However, the underlying mechanisms of EA treatment for the regulation of 5-HT level in CUMS rats are still unclear.…”

Section: Introductionmentioning

confidence: 96%

Electroacupuncture Restores 5‐HT System Deficit in Chronic Mild Stress‐Induced Depressed Rats

Duan

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. The current study is designed to investigate the antidepressant efficacy of electroacupuncture (EA) treatment by evaluating its effect on the synthesis, metabolism, reuptake, and receptors of 5-hydroxytryptamine (5-HT), so as to clarify the molecular mechanisms of EA for antidepression. Materials and Methods. Solitary combined with the chronic unpredictable mild stress (CUMS) was used to establish the rat model with depression. The depressed rats were supplied with EA treatment for 4 weeks, and the behavior change and the following indices including 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), monoamine oxidase A (MAO-A), tryptophan hydroxylase (TPH), 5-HT transporter (SERT), 5-HT1A, and 5-HT2A in hippocampus and prefrontal cortex were examined. Results. EA treatment significantly improved the behavior of rats and increased 5-HT level in hippocampus of depressed rats. Similarly, EA treatment could significantly increase protein and mRNA expression of TPH and 5-HT1A during 5-HT synthesis process in hippocampus of depressed rats. However, EA treatment had no effect on the activity of MAO-A and the expression of SERT protein and mRNA. Conclusion. Antidepressant efficacy of EA treatment can be accomplished through enhancing 5-HT synthesis, upregulating 5-HT1A level, and improving 5-HT content in brain and synaptic gaps.

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“…[2][3][4][5][6][7][8] According to the World Health Organization definition, the term CAM is used interchangeably with "traditional medicine" and refers to a broad set of health care practices, including traditional Chinese medicine, acupuncture, herbal preparations, vitamins, homeopathic remedies, music therapy and other psychological, physical and spiritual techniques. [9,10] The aim of the following study was to examine the association between the usage of CAM and the quality of life (QoL), anxiety and depression and demographic characteristics of women with breast cancer living in the southeast region of Turkey.…”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety and quality of life through the use of complementary and alternative medicine among breast cancer patients in Turkey

et al. 2014

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Efficacy Evaluation for Depression with Somatic Symptoms Treated by Electroacupuncture Combined with Fluoxetine

Cited by 28 publications

References 17 publications

Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway

Electroacupuncture Restores 5‐HT System Deficit in Chronic Mild Stress‐Induced Depressed Rats

Depression, anxiety and quality of life through the use of complementary and alternative medicine among breast cancer patients in Turkey

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