Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma

Wu, Jianming; Zhou, Fangyan; Gao, Yu

doi:10.2147/ccid.s330411

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…It also had the best results for thick IH with a thickness of 2-5 mm. 16,17 Currently, the more popular and efficient option for laser therapy of superficial IH is the pulsed dye laser (PDL). 25 However, thanks to the deeper penetration depth and greater fluence, the long-pulse alexandrite laser is more effective in treating hypertrophic IH, while paired with a skin cooling system to further minimize side effects.…”

Section: Long-pulse Alexandrite Laser In Vascular Lesionsmentioning

confidence: 99%

Applications of Long-Pulse Alexandrite Laser in Cosmetic Dermatology: A Review

Chen,

2023

CCID

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The long-pulse alexandrite laser uses Cr 3+ :BeAl 2 O 4 crystals as the activation medium and has a 755nm wavelength and millisecond pulse duration. The long-pulse alexandrite laser has been utilized for hair removal, vascular lesions, pigmented lesions, and other conditions because melanin and hemoglobin in the skin, subcutaneous tissues, and skin appendages can specifically absorb this type of laser. To serve as a guide and source of inspiration for the clinical use of this type of laser, we review the present research status and advancement of the long-pulse alexandrite laser in the treatment of the aforementioned categories of disorders.

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Section: Long-pulse Alexandrite Laser In Vascular Lesionsmentioning

confidence: 99%

Applications of Long-Pulse Alexandrite Laser in Cosmetic Dermatology: A Review

Chen,

2023

CCID

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Infantile hemangiomas: a dermatologist’s perspective

Sharma,

Gupta,

Mahajan

2024

Eur J Pediatr

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Revealing the mechanism of 755-nm long-pulsed alexandrite laser in inhibiting infantile hemangioma endothelial cells through transcriptome sequencing

Ke,

Chen,

Yang

et al. 2024

Lasers Med Sci

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Laser therapy has shown promising outcomes in treating infantile hemangiomas. However, the molecular mechanisms underlying laser treatment for IH remain incompletely elucidated. This study aimed to unravel the molecular mechanisms of laser therapy in IH treatment. We evaluated the inhibitory effects of laser treatment on the proliferation and promotion of apoptosis in human hemangioma endothelial cells (HemECs) through cell counting kit-8 (CCK-8) assay, Hoechst 33342 staining, and flow cytometric analysis. Transcriptome sequencing analysis of HemECs following laser treatment revealed a significant decrease in the expression level of the GSTM5 gene. The qRT-PCR and western blot analysis also showed that GSTM5 expression in HemECs was downregulated compared to human umbilical vein endothelial cells (HUVECs), and concomitantly, the p62-Nrf2 pathway was suppressed. Using siRNA to downregulate GSTM5 expression, we observed that inhibiting GSTM5 expression could restrain cell proliferation, elevate intracellular ROS levels, and induce apoptosis in HemECs. Furthermore, upon inhibition of the p62-Nrf2 pathway using p62-specific siRNA, a significant decrease in GSTM5 expression and an elevation in intracellular ROS levels were noted in laser-treated HemECs. These findings suggested that laser treatment may operate by inhibiting the p62-Nrf2 pathway, thereby downregulating GSTM5 expression, elevating ROS levels, and consequently inducing apoptosis in HemECs.

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Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma

Cited by 5 publications

References 33 publications

Applications of Long-Pulse Alexandrite Laser in Cosmetic Dermatology: A Review

Applications of Long-Pulse Alexandrite Laser in Cosmetic Dermatology: A Review

Infantile hemangiomas: a dermatologist’s perspective

Revealing the mechanism of 755-nm long-pulsed alexandrite laser in inhibiting infantile hemangioma endothelial cells through transcriptome sequencing

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