Efficacy evaluation of Qingyan formulation in a smoking environment and screening of anti-inflammatory compounds

Cui, Qingxin; Ma, Fang; Jin, Tao; Jiang, Min; Bai, Gang; Luo, Guangsheng

doi:10.1016/j.biopha.2019.109315

Cited by 1 publication

(2 citation statements)

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“…In molecular biological organ studies, LPS has been reported to significantly induce inflammatory factors, such as TNF-α and IL-8, leading to inflammatory injury of bronchi, increased lung index, decreased intestinal villi and thickening of the intestinal wall. 32 Coincidentally, it has been reported that AG can inhibit the expression of inflammatory factors, such as NO, TNF-α and IL-8, in a dose-dependent manner, thus inhibiting the inflammatory response. [33][34][35] This confirmed that it was appropriate to choose AG to study the correlation between the lung and intestine, laying a foundation for follow-up research on the mechanism of action and providing a new appreciation of traditional Chinese medicine theory.…”

Section: Discussionmentioning

confidence: 99%

“…In molecular biological organ studies, LPS has been reported to significantly induce inflammatory factors, such as TNF‐α and IL‐8, leading to inflammatory injury of bronchi, increased lung index, decreased intestinal villi and thickening of the intestinal wall 32 . Coincidentally, it has been reported that AG can inhibit the expression of inflammatory factors, such as NO, TNF‐α and IL‐8, in a dose‐dependent manner, thus inhibiting the inflammatory response 33–35 .…”

Section: Discussionmentioning

confidence: 99%

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Biodistribution of andrographolide to assess the interior‐exterior relationship between the lung and intestine using microPET

Zhang

Cui

2020

Thoracic Cancer

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Background One classic traditional Chinese medicine theory is that the “lung and intestine are exterior‐interiorly related”; however, this has not been confirmed experimentally. The aim of this study was to provide a biological basis for the theory by measuring the tissue distribution of andrographolide. Methods Acute pneumonia was induced in a mouse model by repeated stimulation with lipopolysaccharide. The distribution of andrographolide in mice was observed by positron emission tomography (PET) imaging with [ 18 F]‐labeled andrographolide, and changes in the in vivo distribution before and after modeling were compared. Subsequently, the consistency of pathological changes in lung and intestine was confirmed by observation of pathological sections. Finally, the results were verified by cytokine detection. Results The value of organ uptake, pathological changes and inflammatory factor expression of the lung and intestine were consistent. The concentration of andrographolide in the lung and intestine increased significantly, and was confirmed by pathology and enzyme‐linked immunosorbent assays (ELISA). Conclusions Micro‐positron emission tomography (microPET) can be used to visually observe the distribution of medicinal ingredients in vivo, and [ 18 F]‐andrographolide can be used as a tool to assess the interior‐exterior relationship between the lung and intestine.

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