Efficacy improvement in searching MEDLINE database using a novel PubMed visual analytic system: EEEvis

Lee, Jong-Chan; Lee, Brian J.; Park, Changhee; Song, Hyunjoo; Ock, Chan‐Young; Sung, Hyojae; Woo, Sungjin; Youn, Yeo-Kyu; Jung, Kwangrok; Jung, Jae Hyup; Ahn, Jinwoo; Kim, Bomi; Kim, Jaihwan; Seo, Jinwook; Hwang, Jin Hyeok

doi:10.1371/journal.pone.0281422

Cited by 3 publications

(1 citation statement)

References 25 publications

(27 reference statements)

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“…The search was restricted to PubMed as it is the most widely used database and search engine in the biomedical and healthcare fields. 41 The search strings were launched on 1 st February 2023 and are detailed in Supplementary materials. The resulting articles were screened for inherence with the topics covered in the present review.…”

Section: Methodsmentioning

confidence: 99%

The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence

Marchi,

Fallani,

Salvatore

et al. 2023

Human Vaccines & Immunotherapeutics

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Influenza is a vaccine-preventable disease and a global public health problem. Although most national influenza vaccination recommendations focus on subjects aged ≥65 years, an extensive burden of influenza has also been reported in those aged ≥50 years and is exacerbated by immune system aging. The main purpose of this review is to provide an overview of the burden of influenza and its potential prevention within the 50–64 age-group. These subjects account for a large proportion of the workforce, and play a central economic and social role. Individuals aged 50–64 years had a 3-times higher rate of hospitalization and a 9-fold higher mortality rate attributable to influenza than those aged 18–49-years, generating higher influenza-related hospitalization costs. Available data suggest that including healthy subjects aged 50–64 years in influenza vaccination recommendations would allow a broader population to be reached, reducing the economic and social burden of influenza.

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Section: Methodsmentioning

confidence: 99%

The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence

Marchi,

Fallani,

Salvatore

et al. 2023

Human Vaccines & Immunotherapeutics

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The potential of immunomodulators in shaping the future of healthcare

Sharma,

Arora,

Bala

2024

Discov Med

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Immunomodulators play a crucial role in modern medical practice, offering both stimulatory and suppressive effects to regulate and control the immune response. These substances, which include immunostimulants and immunosuppressants, modulate the immune system by delivering cytokines and stimulating immune cells. Immunosuppressants are vital in liver and kidney transplantation, where they reduce the immune system’s activation to prevent organ rejection. They are also essential in managing autoimmune disorders by providing controlled suppression of immune activities to avoid self-damage. Conversely, immunostimulants enhance the body’s innate immunity, preventing infections, and boosting resistance against various viral and bacterial diseases. These agents strengthen the body’s natural defenses, making them indispensable in infection control and immunoprophylaxis. The mechanisms of immunomodulators are intricate, involving interactions with key molecules such as cytokines and signaling pathways to shape immune responses, mitigate inflammation, and regulate immune cell functions. Mesenchymal stem cells (MSCs) have emerged as a promising component due to their ability to suppress immune reactions, regulate inflammatory responses, induce immune tolerance, and aid in tissue regeneration. MSCs’ unique properties underscore their potential in treating immune-related disorders, supporting organ transplantation, and promoting tissue repair. Clinically, immunomodulators are central to managing autoimmune diseases, enhancing cancer immunotherapy, combating infectious diseases, and preventing organ rejection in transplant recipients. Innovative therapies like checkpoint inhibitors, CAR T-cell therapy, and cancer vaccines have revolutionized oncology by leveraging the immune system's capabilities. This review explores the critical roles and mechanisms of immunomodulators, highlighting their impact on contemporary healthcare and their potential for future therapeutic developments.Graphical Abstract

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Topic Modeling for Faster Literature Screening Using Transformer-Based Embeddings

Galli,

Cusano,

Meleti

et al. 2024

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Systematic reviews are a powerful tool to summarize the existing evidence in medical literature. However, identifying relevant articles is difficult, and this typically involves structured searches with keyword-based strategies, followed by the painstaking manual selection of relevant evidence. A.I. may help investigators, for example, through topic modeling, i.e., algorithms that can understand the content of a text. We applied BERTopic, a transformer-based topic-modeling algorithm, to two datasets consisting of 6137 and 5309 articles, respectively, used in recently published systematic reviews on peri-implantitis and bone regeneration. We extracted the title of each article, encoded it into embeddings, and input it into BERTopic, which then rapidly identified 14 and 22 topic clusters, respectively, and it automatically created labels describing the content of these groups based on their semantics. For both datasets, BERTopic uncovered a variable number of articles unrelated to the query, which accounted for up to 30% of the dataset—achieving a sensitivity of up to 0.79 and a specificity of at least 0.99. These articles could have been discarded from the screening, reducing the workload of investigators. Our results suggest that adding a topic-modeling step to the screening process could potentially save working hours for researchers involved in systematic reviews of the literature.

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Efficacy improvement in searching MEDLINE database using a novel PubMed visual analytic system: EEEvis

Cited by 3 publications

References 25 publications

The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence

The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence

The potential of immunomodulators in shaping the future of healthcare

Topic Modeling for Faster Literature Screening Using Transformer-Based Embeddings

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