Efficacy of 0.1% adapalene in a non-inflammatory Kyoto Rhino Rat acne model

Efficacy of topical adapalene monotherapy for symptomatic relief in a long‐standing vulvar syringoma: A case report and literature review with treatment update

“…Adapalene harbors variable pharmacological actions, including anti‐inflammatory effects via inhibition of proinflammatory cytokines released from the corresponding keratinocytes and inflammatory infiltrates, and increase of extracellular matrix synthesis with a decrease of matrix metalloproteinase activity in dermal fibroblasts expressing adapalene‐bound retinoic acid receptor‐β 8,9 . One may consider that adapalene stimulates the turnover and remodeling of dermal matrix/appendages, together with anti‐inflammatory and anti‐comedogenic actions, 10 contributing to the favorable clinical efficacy in our case.…”