Efficacy of 780-nm Laser Phototherapy on Peripheral Nerve Regeneration after Neurotube Reconstruction Procedure (Double-Blind Randomized Study)

Rochkind, Shimon; Leider-Trejo, Leonor; Nissan, Moshe; Shamir, Merav H.; Kharenko, Oleg; Alon, Malvina

doi:10.1089/pho.2007.2076

Cited by 92 publications

(59 citation statements)

References 29 publications

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“…In the treatment of peripheral nerve injuries, suturing with vinyl and silk was done first; however in light of the number of sutures and the negative effects of the sutures on recovery, fibrin glue and wrapping the injured nerve were also tried. Electrical stimulation, therapeutic ultrasound, low-dose radiation, and low-intensity laser were also tested in experimental models to produce nerve regeneration and functional recovery (8,13,15,16,17).…”

Section: I-light Microscopic Evaluationmentioning

confidence: 99%

Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial

Sezer

Güçlü²,

Kazanci³

et al. 2013

Turkish Neurosurgery

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AIm:The purpose of this study was to demonstrate the activity of agmatine, an inducible nitric oxide synthase (iNOS) inhibitor and selective N-methyl-D-aspartate receptor (NMDAR) antagonist, on reducing tissue damage in distal part of traumatic nerve in an experimental rat peripheral nerve injury model. mATeRIAL and meTHods: Sciatic nerves of 30 Sprague Dawley male rats were used. Rats were divided into 5 groups; group 1 (n=6), control group; group 2 (n=6), axonotmesis + placebo group; group 3 (n=6), axonotmesis + 50 mg/kg agmatine treatment group; group 4 (n=6), neurotmesis + placebo group; group 5 (n=6), neurotmesis + 50 mg/kg agmatine treatment group. Axonolysis, axon degeneration, edema, hemorrhage, and inflammation were evaluated in histopathologic examinations of all the groups.ResuLTs: When group 2 was compared with group 3 in histopathologic sections, axonolysis was less in group 3 (p=0.007), as was axon degeneration (p=0.022) and edema (p=0.018). When group 4 was compared with group 5, axonolysis was less in group 5 (p=0.009), as was axon degeneration (p=0.006) and edema (p=0.021). CoNCLusIoN:This study demonstrated agmatine to have antioxidant and antineurotoxic effects in an experimental rat peripheral nerve injury model. KeywoRds: Agmatine, Axonotmesis, Neurotmesis, Peripheral nerve injury, Rat ÖZ AmAÇ: Bu çalışmanın amacı, indüklenebilir nitrik oksit sentetaz inhibitörü (iNOS) ve selektif N-metil-D-aspartat reseptörü (NMDAR) antagonisti olan agmatinin sıçanlarda yapılan deneysel periferik sinir yaralanma modelinde hasarlı sinirin distal bölumündeki doku hasarını azaltmadaki etkisini göstermekti. yÖNTem ve GeReÇLeR: Otuz tane Sprague Dawley sıçanının siyatik sinirleri kullanıldı. Sıçanlar beş gruba bölündü: birinci grup (n=6), kontrol grubu; ikinci grup (n=6), aksonotmezis + plasebo grubu; üçüncü grup (n=6), aksonotmezis + 50 mg/kg agmatin tedavi grubu; dördüncü Grup (n=6), neurotmesis + plasebo grubu; beşinci grup (n=6), neurotmesis + 50 mg/kg agmatin tedavi grubu. Aksonolizis, akson dejenerasyonu, ödem, hemoraji ve inflammasyon bütün gruplarda histopatolojik olarak değerlendirildi.BuLGuLAR: İkinci grup ile üçüncü grup histopatolojik kesitlerde kıyasladığında, aksonolizis üçüncü grupta daha azdı (p=0,007), aynı şekilde akson dejenerasyonu (p=0,022) ve ödem (p=0,018) üçüncü grupta daha azdı. Dördüncü grup ile beşinci grup histopatolojik kesitlerde kıyasladığında, aksonolizis beşinci grupta daha azdı (p=0,009), aynı şekilde akson dejenerasyonu (p=0,006) ve ödem (p=0,021) beşinci grupta daha azdı. soNuÇ: Bu çalışma, agmatinin sıçanlarda yapılan deneysel periferik sinir yaralanmalarında antioksidan ve antinörotoksik etkileri olduğunu göstermiştir.

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Section: I-light Microscopic Evaluationmentioning

confidence: 99%

Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial

Sezer

Güçlü²,

Kazanci³

et al. 2013

Turkish Neurosurgery

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“…[26][27][28] Most reports on the effect of LLLT on PNS injury are in cases of axonotmesis. [13][14][15][18][19][20][21]25,[29][30][31][32] However, promising results have been obtained in severe cases of neurotmesis when LLLT is used in combination with or Gore-Tex tubes. 27 The cutaneous branch consisted of 400 myelinated and 1800 unmyelinated afferent axons.…”

Section: Introductionmentioning

confidence: 99%

Stimulation Effect of Low Level Laser Therapy on Sciatic Nerve Regeneration in Rat

et al. 2017

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IntroductionThe nerve fiber or axon, is responsible for transmitting information between neuron cells. 1 In humans, axons are generally on the scale of 1 μm thick and some are more than 1 m long, 1 and in the peripheral nerve system (PNS), they are either unmyelinated or myelinated by Schwann cells.2 These cells are mainly wrapped around axons and form a multi-layered sheath preparing myelin structures for axons. 2,3 In case of injury, Schwann cells are activated and play a key role in nerve repair mechanism, not only concerning Wallerian degeneration and remyelination in the injured position, but also in promoting axonal growth. 4 Wallerian degeneration occurs when an axon is cut or injured, in which the axon degenerates distal to the injury site. [5][6][7] This is followed by secondary phenomena such as breakdown of the myelin sheet and activation of the Schwann and macrophages that clear up the debris. 8,9Nerve injuries are divided into 3 basic categories of neuropraxia, axonotmesis and neurotmesis based on the extent of injury, pathology and physiology according to Sir Herbert Seddon's scheme, 5,6 neuropraxia, the mildest nerve injury, is a temporary loss of sensory function. 10The injured site usually fully recovers within few weeks or months, and no Wallerian degeneration occurs in this type of injury. Axonotmesis is when axons are more seriously damaged and interrupted. 10 In this type of injury, the surrounding epineurium and perineurium layers remain almost intact, but there could be only partial recovery depending on the extent of injury to the axons. In addition, Wallerian degeneration may occur distal to Methods:In this research work, the effect of LLLT (780 nm) on the regeneration process and reconstruction of injured peripheral right side sciatic nerve was investigated. Twelve adult male Wistar rats underwent surgery in aseptic conditions under general anesthesia to induce a lesion to their right side sciatic nerve according to standard protocol. Before suturing the location, only the experimental group was treated by laser. The damaged nerve was directly irradiated with (2 J, 100 mW, 40 seconds). The irradiation procedure was terminated in 21 days with little improvement (4 J, 200 mW, 40 seconds) across the skin surface of experimental group. Rats were selected randomly from each group to be sacrificed on different periods and histopathological examination was carried out on the extracted nerves.Results: Significant acceleration of revascularization and angiogenesis of the injury site was observed in the experimental group. Furthermore, a reduction of hemorrhages and increase in blood supply was observed. Also, Wallerian degeneration decreased while higher axonal density compared to the control rats was observed. Moreover, the cross-section analysis of the injured area on the 14th and 21st days as post-surgery showed that the nerve sheath diameter in the lesion area of the experimental group was reduced. While the ratio between thicknesses increased in the control group. Conclusion:The results of...

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“…Medicinal management often includes antidepressants but, as studied by Tammialia-Salonen et al antidepressants did not effectively relieve BMS associated symptoms 29 . Effectiveness of LLLT in peripheral nerve regeneration was demonstrated in several studies [30][31][32] . Nerve regeneration and acceleration of axonal growth was observed in rats after the application of 780 nm laser 30 .…”

Section: Discussionmentioning

confidence: 99%

“…Effectiveness of LLLT in peripheral nerve regeneration was demonstrated in several studies [30][31][32] . Nerve regeneration and acceleration of axonal growth was observed in rats after the application of 780 nm laser 30 . In another study, rabbits who were treated with 901 nm laser showed thicker nerve fibers, clearer Ranvier nodes and more regular myelin layers, compared to control group 31 .…”

Section: Discussionmentioning

confidence: 99%

he effects of low level laser therapy on the management of chronic idiopathic orofacial pain: trigeminal neuralgia, temporomandibular disorders and burning mouth syndrome

et al. 2017

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Abstract. Aim: To investigate the efficacy of different wavelengths of low level laser therapy (LLLT) in the management of orofacial pain by measuring the pain reduction using visual analogue scale (VAS). Materials and methods: Study involved 20 patients with trigeminal neuralgia (TN), 20 with temporomandibular disorders (TMD) and 40 with burning mouth syndrome (BMS). 50 % of the patients in each syndrome group were treated with 660 nm laser, and other 50 % with 810 nm laser. Orofacial pain was quantified by the VAS. Results: VAS was significantly lower after the application of LLLT, in all subjects and for both applied wavelengths (P < 0.05). Efficacy of 810 nm laser compared to 660 nm laser was significantly higher for all patients and in both the TN and TMD groups (P < 0.001; P = 0.005; P = 0.024). Conclusions: LLLT has proven to be an effective intervention in reducing pain in TN, TMD and BMS patients. Better results can be achieved with higher wavelengths.Key words: burning mouth syndrome; facial pain; lasers; pain measurement; temporomandibular joint disorders; trigeminal neuralgia Sažetak. Cilj: Ispitati učinke različitih valnih duljina mekog lasera (ML) u liječenju orofacijalnog bola mjerenjem prijavljenog bola na vizualno-analognoj skali (VAS). Materijali i metode: U istraživanju je sudjelovalo 20 ispitanika s trigeminalnom neuralgijom (TN), 20 s temporomandibularnim poremećajima (TMP) i 40 sa sindromom pekućih usta (SPU). 50 % ispitanika u svakoj skupini liječeno je laserom 660 nm, a preostalih 50 % laserom 810 nm. Orofacijalni bol određen je prema VAS-u. Rezultati: Nakon primjene ML-a prijavljeni bol bio je značajno manji za sve ispitanike (P < 0,05). Značajno veće smanjenje bola ostvareno je primjenom lasera 810 nm za sve pacijente te za TN i TMP grupu (P < 0,001; P = 0,005; P = 0,024). Zaključci: ML pokazao se učinkovitom metodom smanjenja bola kod TN-a, TMP-a i SPU-a. Bolji rezultati ostvaruju se primjenom veće valne duljine.Ključne riječi: bol lica; laseri; mjerenje bola; poremećaji temporomandibularnog zgloba; sindrom pekućih usta; trigeminalna neuralgija

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Efficacy of 780-nm Laser Phototherapy on Peripheral Nerve Regeneration after Neurotube Reconstruction Procedure (Double-Blind Randomized Study)

Abstract: The results of this study suggest that postoperative 780-nm laser phototherapy enhances the regenerative process of the peripheral nerve after reconnection of the nerve defect using a PGA neurotube.

Cited by 92 publications

References 29 publications

Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial

Neuroprotective effects of agmatine in experimental peripheral nerve injury in rats: a prospective randomized and placebo-controlled trial

Stimulation Effect of Low Level Laser Therapy on Sciatic Nerve Regeneration in Rat

he effects of low level laser therapy on the management of chronic idiopathic orofacial pain: trigeminal neuralgia, temporomandibular disorders and burning mouth syndrome

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