Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks

Hirsiger, Constanze; Schmidlin, Patrick R.; Michaelis, Mary; Hirsch, Christian R; Attin, Thomas; Heumann, Christian; Doméjean, Sophie; Gernhardt, Christian Ralf

doi:10.1016/j.jdent.2019.01.002

Cited by 19 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the model pattern for the samples treated with saliva immersion suggests that the effectiveness of proargin would require a longer period than seven days to effectively occlude the tubules. This is in agreement with the recent clinical finding that proargin achieved significant relief of DH after application for 24 weeks [3].…”

Section: Discussionsupporting

confidence: 93%

“…A previous study [2] reported that more than 80% of children and up to 43% of adult's population suffer from dental pain associated with DH. More worrisome is that DH negatively affects the quality of life of dental patients if left untreated [3]. Consequently, numerous dentin remineralization strategies have been proposed in the literature [4, 5] for the management of DH.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Application of the Logistic Equation Model to Predict the Remineralization Characteristics of Desensitizing Paste

Onwubu

Mdluli

Singh

et al. 2019

International Journal of Dentistry

View full text Add to dashboard Cite

Objectives A mathematical model making using of the Verhulst logistic equation was developed to predict the remineralization behaviors of desensitizing paste. Methods The input parameter used for the model was obtained experimentally by brushing twenty-one simulated dentin specimens for seven days with three sample groups, namely, EB@TiO2, Colgate Pro-relief, and Sensodyne repair (n = 7). A field emission scanning electron microscope (FESEM) and ImageJ software were used to observe and measure the % occluded ratio of the dentin surface. The model fittings for the three sample groups were carried out using the built-in MATLAB least-squares fitting routine fmincon in the optimization toolbox. Results The results suggest that the experimental parameter were in agreement with the model. It was found that the logistic equation model can make a future prediction of the remineralization pattern for EB@TiO2 and Colgate Pro-relief. It was, however, found that the trajectory for the Sensodyne repair was a bit complex, thus making the prediction difficult. Conclusions Overall, the salient feature of this study suggests that the logistic equation could be used to predict the remineralization behavior of desensitizing paste in the management of sensitive tooth.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Application of the Logistic Equation Model to Predict the Remineralization Characteristics of Desensitizing Paste

Onwubu

Mdluli

Singh

et al. 2019

International Journal of Dentistry

View full text Add to dashboard Cite

show abstract

“…It may also be attributed to the placebo effect which was common in the clinical studies of desensitizing pastes. Placebo products could reduce hypersensitivity by as much as 40% from baseline and therefore have an effect on the efficacy measurement of test dentifrice [31]. Another factor may be the Hawthorne effect.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

Ding

Dai

et al. 2020

BMC Oral Health

View full text Add to dashboard Cite

Background: Dentine hypersensitivity (DH) could occur or intensify after non-surgical periodontal therapy because of the exposure of dentine tubules, but currently no gold standard exists to treat DH. It has been demonstrated that nano-sized particles presented potential for dentine tubules blocking and remineralization. This randomized controlled trial aimed to investigate the efficacy of dentifrice containing nano-carbonate apatite (n-CAP) in reducing dentine hypersensitivity (DH) after non-surgical periodontal therapy. Methods: 48 periodontitis patients with DH were included in this clinical trial. After non-surgical periodontal therapy, patients included were randomized to test and control group and the respective dentifrices were applied at chairside, after which they were instructed to brush teeth with the allocated dentifrices twice a day at home. Periodontal parameters were recorded at baseline and the last follow-up. DH was measured by air-blast test and recorded by visual analogue scale (VAS) and Schiff sensitivity scale at baseline, after polishing (0 week) and 2/4/6 weeks. Results: 45 participants completed the follow-up. Periodontal parameters were improved and comparable between groups. Significant reduction in DH was observed in both groups at all time-points compared to baseline in terms of VAS and Schiff score. The test group achieved significantly greater relief from hypersensitivity compared with the control group after 4-week at-home use (for change of VAS, test group: 2.27 ± 2.47 versus control group: 1.68 ± 2.24, p = 0.036; for change of Schiff, test group: 0.94 ± 0.92 versus control group: 0.61 ± 0.83, p < 0.001). The 6-week results showed borderline significance between groups in terms of change of Schiff (p = 0.027) and no significance in terms of change of VAS (p = 0.256).

show abstract

“…44 This notwithstanding, Colgate brands like calcium–arginine combination have been reported to be highly effective in occluding dentin tubules. 45,46…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of nanohydroxyapatite synthesized from eggshell waste in occluding dentin tubules

Onwubu

Mhlungu

Mdluli

2019

Journal of Applied Biomaterials & Functional Materials

View full text Add to dashboard Cite

Objectives: Dentin hypersensitivity (DH) is a notable painful condition with a negative impact on quality of life. This paper evaluates the occluding abilities of nanohydroxyapatite synthesized from the eggshell waste (EnHAp) in the treatment of DH. Methods: EnHAp was synthesized following the wet chemical precipitation method. The purity and phase change were characterized using Fourier transform infrared (FTIR) and X-ray diffraction (XRD). Field emission scanning electron microscopy (FESEM) and high-resolution transmission electron microscopy (HRTEM) were used to observe the morphology of EnHAp. The occluding capabilities were evaluated in vitro using the bovine model. Twenty-five simulated dentin specimens were randomly assigned to five groups: Group 1, untreated; Group 2, eggshell powder alone; Group 3, calcined eggshell powder; Group 4, Colgate Sensitive treated, EnHAp; and Group 5, calcium dihydrogen phosphate (n = 5). The specimens were then subjected to remineralization protocol. The tubule occluding capabilities were observed using FESEM. Analysis of variance was used to analyze the occluding ratio values for all treated specimens. Post hoc test with Bonferroni correction was used to identify the mean differences among the five test groups (α = .05). Results: The FTIR and XRD results confirm that synthesis of EnHAp occurred. HRTEM and FESEM revealed an irregular rod structure with a particle size of 65 nm. The occluding area ratios observed for the EnHAp specimens were significantly higher than other test groups (p < 0.001). Conclusions: The application of EnHAp resulted in an efficient occlusion of dentin tubule. This study suggests that EnHAp is an effective therapy to treat DH.

show abstract

Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks

Cited by 19 publications

References 27 publications

The Application of the Logistic Equation Model to Predict the Remineralization Characteristics of Desensitizing Paste

The Application of the Logistic Equation Model to Predict the Remineralization Characteristics of Desensitizing Paste

Efficacy of nano-carbonate apatite dentifrice in relief from dentine hypersensitivity following non-surgical periodontal therapy: a randomized controlled trial

In vitro evaluation of nanohydroxyapatite synthesized from eggshell waste in occluding dentin tubules

Contact Info

Product

Resources

About