Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs

Cavana, Paola; Petit, Jean-Yanique; Perrot, S.; Guechi, R.; Marignac, Geneviève; Reynaud, Karine; Guillot, Jacques

doi:10.1016/j.mycmed.2015.10.004

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…Malassezia pachydermatis populations varied between anatomical sites in healthy basset hounds, with higher populations on the pinnae when compared with the perineal area . Contact plate counts of M. pachydermatis were reduced by both oral ketoconazole and oral terbinafine in healthy basset hounds, by climbazole shampoo in research beagle dogs, and by chlorhexidine and climbazole wipes in a pilot study of five shar pei dogs …”

Section: Quantification Of Malassezia Populations On Canine and Felinmentioning

confidence: 96%

“…However, recommendations for weekly antifungal shampoo bathing as a preventive strategy to reduce the frequency of recurrent Malassezia dermatitis appear anecdotal rather than evidence‐based . Studies in vitro that demonstrate shampoo persistence on hairs may or may not be relevant to persistence on skin, and studies in vivo on topical therapy persistence were conducted in normal dogs rather than in dogs with Malassezia dermatitis …”

Section: Prevention Of Malassezia‐associated Skin Diseases In Dogs Anmentioning

confidence: 99%

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Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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Background -The genus Malassezia is comprised of a group of lipophilic yeasts that have evolved as skin commensals and opportunistic cutaneous pathogens of a variety of mammals and birds.Objectives -The objective of this document is to provide the veterinary community and other interested parties with current information on the ecology, pathophysiology, diagnosis, treatment and prevention of skin diseases associated with Malassezia yeasts in dogs and cats.Methods and material -The authors served as a Guideline Panel (GP) and reviewed the literature available prior to October 2018. The GP prepared a detailed literature review and made recommendations on selected topics. The World Association of Veterinary Dermatology (WAVD) Clinical Consensus Guideline committee provided guidance and oversight for this process. The document was presented at two international meetings of veterinary dermatology societies and one international mycology workshop; it was made available for comment on the WAVD website for a period of six months. Comments were shared with the GP electronically and responses incorporated into the final document.Conclusions and clinical importance -There has been a remarkable expansion of knowledge on Malassezia yeasts and their role in animal disease, particularly since the early 1990's. Malassezia dermatitis in dogs and cats has evolved from a disease of obscurity and controversy on its existence, to now being a routine diagnosis in general veterinary practice. Clinical signs are well recognised and diagnostic approaches are well developed. A range of topical and systemic therapies is known to be effective, especially when predisposing factors are identified and corrected.

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Section: Quantification Of Malassezia Populations On Canine and Felinmentioning

confidence: 96%

Section: Prevention Of Malassezia‐associated Skin Diseases In Dogs Anmentioning

confidence: 99%

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Bond

Morris

Guillot

et al. 2020

Veterinary Dermatology

118

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“…The use of azole drugs to reduce Malassezia numbers has been extensively reported, although few randomized controlled trials have been conducted . A variety of non‐azole treatments for MAD have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The use of azole drugs to reduce Malassezia numbers has been extensively reported, although few randomized controlled trials have been conducted. 2,[22][23][24] A variety of non-azole treatments for MAD have been reported. In an uncontrolled study, 20 dogs with pododermatitis were treated with a gel containing ethanol, triclosan and glycerine (PawCare â ).…”

Section: Discussionmentioning

confidence: 99%

A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

Sjöström¹,

Mellor²,

Bergvall

2017

Veterinary Dermatology

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Background -Malassezia yeast overgrowth on the skin is a common and often recurrent cause of dermatitis in dogs; it can be an exacerbating factor of atopic dermatitis. Anti-fungal drugs have been a standard treatment, but there is some concern that resistance may be evolving in a spectrum of Malassezia species. Safe, efficient and easy-to-use alternatives are needed.Objectives -To assess if a commercially available topical non-azole solution applied to paws affected by Malassezia-associated dermatitis (MAD), could ameliorate Malassezia numbers and associated signs over a short term (14 day) trial. Animals -Eighteen dogs with MAD affecting at least two paws.Methods -The study design was prospective, randomized, blinded and placebo-controlled, using a split-body protocol. Dogs were treated once daily with the test solution on one paw and placebo on the other. Dogs were examined at days 0 and 14 AE 3. The primary end-point was Malassezia numbers assessed cytologically. Secondary end-points were clinical scores for lesion severity and pruritus as assessed by a pruritus Visual Analog Scale (PVAS). Owner compliance and adverse effects were assessed.Results -There was a statistically significant reduction in Malassezia numbers and clinical scores for paws treated with the test solution versus placebo. No statistical difference in PVAS was found.Conclusion -Daily topical application of the test solution was effective in reducing the Malassezia burden, as well as improving clinical scores in dogs with MAD of the paws. No adverse effects were reported and owners described the product as either "easy" or "very easy" to use.

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“…1) Bayside Animal Hospital, 2) Wako Filter Technology, 3) Teikyo University Malassizia pachydermatis 4,8,21) Malassezia spp.…”

Section: -Lyzoxmentioning

confidence: 99%

Evaluation of the effect of a lysozyme-chitosan sugar complex (LYZOX) and decanoic acid spray on local lesions of nine dogs suspected of Malassezia dermatitis

真紀子¹,

宏紀²,

陽平³

et al. 2019

Jpn J Vet Dermatol

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Malassezia Dermatitis is a common skin disease in dogs and likely to recur. Conventionally, azole-based antifungals have been used systemically or topically, however their use has been associated with problems of drug resistance and hepatotoxicity, and the shampoo therapy can be very difficult for some patients and owners (at home). There is a skin conditioning spray product which is used mainly by human care facilities which contains D-LYZOX as the chief active ingredient. We evaluated its clinical effectiveness against local lesions on nine dogs with suspected Malassezia Dermatitis, applying it twice a day for three weeks. One case had mild erythema at the start of treatment, but natural recovery occurred immediately. The dermatitis severity score and PVAS of the spray-treated dogs significantly decreased (P<0.01). The counts of Malassezia spp. in the lesions were lower, but the results were not statistically significant. In order to verify the contribution of the anti-inflammatory property of this formulation to the improvement of the dermatitis severity score and PVAS of the cases, we examined the effects of D-LYZOX on neutrophil adhesion as an in vitro parameter of inflammatory reaction. D-LYZOX inhibited lipopolysaccharide-induced adhesion of neutrophils obtained from a normal dog, suggesting the anti-inflammatory activity of D-LYZOX. These results suggest that this spray formulation containing D-LYZOX can improve the PVAS and dermatitis severity score of suspected local Malassezia dermatitis in dogs. We also discussed the need to clarify these clinical effects and their association with the suppression of neutrophil function.

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Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs

Cited by 15 publications

References 20 publications

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

Biology, diagnosis and treatment ofMalasseziadermatitis in dogs and cats Clinical Consensus Guidelines of the World Association for Veterinary Dermatology

A novel non‐azole topical treatment reducesMalassezianumbers and associated dermatitis: a short term prospective, randomized, blinded and placebo‐controlled trial in naturally infected dogs

Evaluation of the effect of a lysozyme-chitosan sugar complex (LYZOX) and decanoic acid spray on local lesions of nine dogs suspected of Malassezia dermatitis

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