Purpose
This study aimed to improve cancer-related fatigue (CRF) and health outcomes of colorectal cancer patients by understanding the status quo of CRF, exploring the relations of coping, anxiety symptoms, depressive symptoms, body image perception and CRF, and also identifying the factors affecting CRF based on a generalized linear modeling approach.
Patients and Methods
An exploratory cross-sectional study was conducted on 370 colorectal cancer patients at two hospitals in Anhui Province, China, from July 2020 to February 2021. The data were collected by using general information questionnaire, cancer fatigue scale, simplified coping style questionnaire, generalized anxiety disorder-7 scale, patient health questionnaire-9, and body image scale. Descriptive statistics,
t
-tests, one-way analysis of variance, Pearson correlation analyses, and generalized linear model analyses were applied to analyze the data.
Results
The average CRF score of the patients was 21.612 (
SD
=6.160), with a prevalence rate of 69.4% for clinically relevant fatigue. The generalized linear model revealed that: In step 1, gender (female) (
B
=1.799, Wald
χ
2
=7.506,
p
=0.006), per capita monthly income (1001–3000 RMB) (
B
=−1.673, Wald
χ
2
=5.536,
p
=0.019) and treatment modalities (chemotherapy+others) (
B
=2.425, Wald
χ
2
=8.211,
p
=0.004) were related to CRF. In step 2, depressive symptoms (
B
=1.223, Wald
χ
2
=129.019,
p
<0.001) and negative coping strategies (
B
=0.215, Wald
χ
2
=11.347,
p
=0.001) exhibited significant positive correlations with CRF, positive coping strategies (
B
=−0.319, Wald
χ
2
=59.175,
p
<0.001) showed significant negative correlations with CRF; While anxiety symptoms (
B
=0.162, Wald
χ
2
=1.840,
p
=0.175) and body image perception (
B
=0.013, Wald
χ
2
=0.048,
p
=0.826) had no correlations with CRF.
Conclusion
The prevalence of CRF was relatively high among colorectal cancer patients. Coping and depressive symptoms were the modifiable influencing factors of CRF. Tailored interventions dedicated to promoting positive coping behavior, diminishing negative coping behavior and redu...