Efficacy of a collagen hydrolysate and antioxidants‐containing nutraceutical on metrics of skin health in Indian women

Abstract

Background The skin’s aging process involves a decreased biosynthesis of extracellular matrix proteins (predominantly collagen) compounded by damage from environmental and intrinsic stressors. The Indian population is susceptible to skin damage given its geography and increasing urbanization or a genetic disposition. Previous studies have investigated nutrients such as collagen peptides, vitamins and phytonutrient‐rich botanical extracts for their individual benefits on skin. Aims This study examined the collective effect of a proprietary blend of these nutrients (in Nutrova Collagen+Antioxidants; NCA) on skin parameters, which has not been previously studied, especially in an Indian context. Patients/Methods 34 healthy, Indian women (mean age = 39.5 years) were given a placebo daily for 30 days to establish a baseline, followed by NCA for two intervals of 30 days. 3D image reconstruction allowed the analysis of skin topography and blemishes. Instrumental measurements also included skin firmness, elasticity, hydration, and transepidermal water loss. Clinical evaluation was used to grade blemishes, wrinkles and periorbital hyperpigmentation. Results Based on instrumental evaluation, NCA significantly reduced wrinkle width, open pores, skin roughness, and the colour of hyperpigmented blemishes, while improving skin hydration, firmness and barrier function from baseline to Day 30 and Day 60. NCA also increased elasticity at Day 30. Clinical evaluation showed that periorbital hyperpigmentation and wrinkles reduced significantly. Conclusion NCA is effective for improving overall skin health in Indian women. These results show that targeted nutrient supplementation can improve skin health and further research over extended durations is merited.

Uso do extrato de sementes de uva e suas implicações no processo de envelhecimento da pele

“…Os anos de publicação dos artigos variaram entre 2007 e 2021. A maioria (92,3%; n= 12) dos artigos estava no idioma inglês (Lacroix et al, 2007;Costa et al, 2012;Bojanowski, 2013;Costa et al, 2015;Dumoulin et al, 2016;Decean et al, 2018;Motwani et al, 2020;Huber et al, 2021;Michailidis et al, 2021;Rafique et al, 2021;Xie et al, 2021;Yarovaya et al, 2021), enquanto que apenas um (7,9%) estava no idioma português (Costa et al, 2011).…”

Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation

“…The use of natural ingredients such as tomato extract or tomato seed oil in cosmetic products for skin care and health has also received popularity over the last few years [ 85 , 86 , 87 , 121 , 284 , 287 , 291 , 292 , 293 , 294 , 295 , 296 , 297 ]. Tomato seed oil has been extensively used in the production of cosmetic and personal care products such as anti-aging serums, body butter, sunscreens, and skin lightening cream due to its high linoleic acid, lecithin, antioxidant, and natural UV protection attributes [ 284 ].…”

“…Other reported benefits of tomato compounds for skin health include the protection against tick bites and heavy metal toxicity [ 64 , 121 , 292 , 296 , 299 ]. Boulanger et al showed that natural skin repellents made from eucalyptus, tomato, and coconut can protect against tick-borne infections such as Lyme disease [ 63 ].…”

“…The mechanism of action involves the preservation of nuclear DNA integrity from heavy metal damage by inducing the genes responsible for DNA repair and protection and also involves the neutralisation of the effect of heavy metals on collagen degradation by inhibiting collagenase expression and inducing the synthesis of new collagen [ 292 ]. Additionally, in a study involving Indian women, Nutrova, a blend of collagen peptides and natural antioxidants from tomatoes, green tea, and grapes, has been shown to significantly reduce wrinkles, skin roughness, and hyperpigmentation while improving skin hydration and firmness [ 296 ]. Similarly, another study of 4000 women showed that a diet reported as high in potassium and vitamins A and C correlated to fewer wrinkles in patients’ skin [ 291 ].…”

Boosting the Photoaged Skin: The Potential Role of Dietary Components

“…Another study showed that oral supplementation with collagen hydrolysate and antioxidant-containing nutraceuticals significantly decreased wrinkle width, open pores, skin roughness, and the color of hyperpigmented blemishes, and enhanced skin hydration, firmness, elasticity, and barrier function, in female participants’ eye skin [ 124 ].…”