Efficacy of a Combination of <i>Melissa officinalis</i> L. and <i>Nepeta menthoides</i> Boiss. &amp; Buhse on Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial

Ranjbar, Maryam; Salehi, Alireza; Rezaeizadeh, Hossein; Zarshenas, Mohammad M.; Sadeghniiat-Haghighi, Khosro; Mirabzadeh, Mehran; Firoozabadi, Ali

doi:10.1089/acm.2017.0153

Cited by 13 publications

(7 citation statements)

References 19 publications

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“…Another research group from Iran also discovered the combination of M. officinalis and Nepeta menthoides Boiss. & Buhse in sleep disorder [134]. A total of 102 patients participated in this study, but only 80 were selected after the screening.…”

Section: Clinical Studiesmentioning

confidence: 99%

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[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

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Section: Clinical Studiesmentioning

confidence: 99%

“…Selected patients have been treated with the dose of 1000 mg of M. officinalis plus 400 mg of N. menthoides or a placebo for four weeks. The 4-week trial demonstrated that a combination of both showed significant activity against insomnia (Trial registration number: IRCT2015040621592N2) [134].…”

Section: Clinical Studiesmentioning

confidence: 99%

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

Sharifi‐Rad

Quispe

Herrera‐Bravo

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…For centuries, MO has been used in traditional Chinese medicine (TCM), traditional Persian medicine (TPM), Ayurvedic medicine, Arabic medicine, and medieval European medicine for treating diverse health conditions, such as insomnia, migraines, neuroses, and hysteria, among others ( Shakeri et al, 2016 ). In the modern pharmacological studies, various human clinical trials ( Kennedy et al, 2002 ; Akhondzadeh et al, 2003 ; Kennedy et al, 2003 ; Kennedy et al, 2004 ; Kennedy et al, 2006 ; Cases et al, 2011 ; Alijaniha et al, 2015 ; Ranjbar et al, 2018a ; Ranjbar et al, 2018b ; Haybar et al, 2018 ; Heydari et al, 2018 ; Soltanpour et al, 2019 ; Araj-Khodaei et al, 2020 ; Noguchi-Shinohara et al, 2020 ; Shirazi et al, 2021 ), animal models ( Coleta et al, 2001 ; Guginski et al, 2009 ; Ibarra et al, 2010 ; Yoo et al, 2011 ; Taiwo et al, 2012 ; Feliú-Hemmelmann et al, 2013 ; Lin et al, 2015 ; Ghazizadeh et al, 2020 ; Talebi et al, 2022 ), and in vitro studies ( Kennedy et al, 2003 ; Awad et al, 2007 ; Awad et al, 2009 ; López et al, 2009 ; Sahin et al, 2016 ) have investigated the neurotherapeutic effects of MO extract, with most studies reporting its antidepressant, anti-stress, anxiolytic, anti-insomnia, and anti-oxidative stress (neuroprotective) properties. According to reported evidence, the neuropharmacological effects of MO extract are due to its various biological properties, i.e., its GABAergic properties (upregulation of γ-amino butyric acid (GABA) through GABA-transaminase (GABA-T) inhibition ( Awad et al, 2007 ; Awad et al, 2009 ; Yoo et al, 2011 ), GABA A receptor affinity ( Salah and Jäger, 2005 ; Abuhamdah et al, 2008 ; Sahin et al, 2016 )), modulation of the serotonergic pathway ( Dimpfel and Suter, 2008 ; Lin et al, 2015 ), and inhibition of acetylcholine esterase (AChE) ( Perry et al, 1996 ; Ferreira et al, 2006 ; Dastmalchi et al, 2009 ) and monoamine oxidase (MAO) enzymes ( Ulbricht et al, 2005 ; López et al, 2009 ; Taiwo ...…”

Section: Introductionmentioning

confidence: 99%

The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial

Bano,

Hepsomali,

Rabbani

et al. 2023

Front. Pharmacol.

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Background: Emotional distress conditions such as depression, anxiety, stress, and poor sleep are widespread health problems that have a significant impact on people’s lives. Conventional drugs are commonly prescribed to treat emotional distress and poor sleep conditions; however, these medications have several limitations and have shown multiple side effects. Over recent years botanicals-based pharmacological agents have gained increasing research and clinical interest in the management of emotional distress and sleep disorder. Of note, Melissa officinalis L. (MO) leaf extract has demonstrated considerable neuropharmacological properties both in animal and human studies and has emerged as a promising natural “calming agent.” However, research in this area is limited, and more studies are needed to validate its efficacy in amelioration of emotional distress and poor sleep conditions.Objectives: We aimed to assess the pharmacological effects of subchronic supplementation of an innovative standardised phospholipid carrier-based MO aqueous extract on emotional distress and poor sleep conditions.Design: A 3-week prospective, randomised, placebo-controlled, parallel-group, double-blinded clinical trial was conducted in 100 healthy adults complaining of a moderate degree of depression, anxiety, or stress, with scores of ≥14, ≥10, and ≥19, respectively, in the self-report Depression, Anxiety, and Stress Scale (DASS-42) or poor sleep, as indicated by the score of >5 in the Pittsburgh Sleep Quality Index (PSQI) scale. In addition, the impact of emotional distress and/or poor sleep on participants’ mental wellbeing, emotional feelings, and quality of life was also assessed using the self-reported Warwick–Edinburgh Mental Wellbeing Scale (WEMWBS), Positive and Negative Affect Schedule (PANAS) scale, and quality of life (WHO-QoL-BREF) scale, respectively.Results: Oral supplementation of 200 mg of phospholipid-based MO aqueous extract (Relissa™) tablets twice a day (i.e., 400 mg/day) for 3 weeks led to significant improvements in the depressive mood, anxiety, stress, positive and negative affect (emotional feelings), overall mental wellbeing, and quality-of-life scores (all p values <0.001). Supplementation of MO extract was well tolerated, and no treatment-emergent effects or serious adverse events were reported.Conclusion: According to the results of this study, the phospholipid carrier-based MO aqueous extract possesses considerable neuropharmacological properties, and its supplementation may provide a promising therapeutic option for the management of moderate emotional distress and/or poor sleep conditions.Clinical Trial Registration:clinicaltrials.gov, identifier NCT05602688.

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“…Another research group also discovered the combination of M. officinalis and Nepeta menthoides Boiss. & Buhse in sleep disorder [88]. The trial evaluated 80 patients treated with the 1000 mg dose of M. officinalis plus 400 mg of N. menthoides or a placebo for four weeks.…”

Section: Human Clinical Trialsmentioning

confidence: 99%

Correction: Wissam Zam et al. An Updated Review on The Properties of Melissa officinalis L.: Not Exclusively Anti-anxiety. Frontiers in Bioscience-Scholar. 2022; 14: 16

Zam¹,

Quispe²,

Sharifi‐Rad³

et al. 2022

Front. Biosci. (Schol Ed)

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Melissa officinalis L. is a plant of the Lamiaceae family known in numerous countries for its medicinal activities. This plant has been used since ancient times to treat different disorders, including gastrointestinal, cardiovascular, neurological, psychological conditions. M. officinalis contains several phytochemicals such as phenolic acids, flavonoids, terpenoids, and many others at the basis of its pharmacological activities. Indeed, the plant can have antioxidant, anti-inflammatory, antispasmodic, antimicrobial, neuroprotective, nephroprotective, antinociceptive effects. Given its consolidated use, M. officinalis has also been experimented with clinical settings, demonstrating interesting properties against different human diseases, such as anxiety, sleeping difficulties, palpitation, hypertension, depression, dementia, infantile colic, bruxism, metabolic problems, Alzheimer's disease, and sexual disorders. As for any natural compound, drug, or plant extract, also M. officinalis can have adverse effects, even though the reported events are very rare and the plant can be considered substantially safe. This review has been prepared with a specific research strategy, interrogating different databases with the keyword M. officinalis. Moreover, this work analyzes the properties of this plant updating currently available literature, with a special emphasis on human studies.

show abstract

Efficacy of a Combination of Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse on Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial

Abstract: A combination of M. officinalis and N. menthoides Boiss. & Buhse could be an alternative sleep improvement therapy.

Cited by 13 publications

References 19 publications

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

[Retracted] Phytochemical Constituents, Biological Activities, and Health‐Promoting Effects of the Melissa officinalis

The possible “calming effect” of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial

Correction: Wissam Zam et al. An Updated Review on The Properties of Melissa officinalis L.: Not Exclusively Anti-anxiety. Frontiers in Bioscience-Scholar. 2022; 14: 16

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