Efficacy of a <i>Ceratothoa oestroides</i> Olive Oil Extract in Patients With Chronic Ulcers: A Pilot Study

Vitsos, Andreas; Tsagarousianos, Christos; Vergos, Orestis; Stithos, Dionysios; Mathioudakis, Dimitrios; Vitsos, Ioannis; Zouni, Panayota; Kakolyri, Athina; Meimeti, Evangelia; Kyriazi, Maria; Antoniadou, Ioanna; Tentolouris, Nikolaοs; Dallas, Paraskevas; Roussis, Vassilios; Rallis, Michail

doi:10.1177/1534734619856143

Cited by 9 publications

(14 citation statements)

References 42 publications

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“…In a pilot study, Vitsos et al examined the effect of Ceratothoa oestroides olive oil extract in people with chronic ulcers. Treatment was evaluated using the Bates-Jensen scale, and the results showed that the overall wound score decreased by 36% ( P < 0.001) [ 9 ].…”

Section: Topical Applications Of Olivementioning

confidence: 99%

“…e evergreen olive tree (Olea europaea) is a natural source of antioxidants and other bioactive compounds that come from different parts of the olive [3]. e effectiveness of olives on wound healing has been investigated in several studies [4][5][6][7][8][9][10][11][12]. In general, olives have antioxidant, antibacterial, anti-inflammatory [13], and antiviral properties and, therefore, can facilitate the repair of epithelial tissue, which is effective in the wound healing process [14].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Taheri

Amiri‐Farahani

2021

Dermatology Research and Practice

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Background and Objective. Olive oil is used as a traditional treatment for wounds, sores, and infections, and the effectiveness of topical use and absence of side effects have been reported in various clinical trials. The present study is an overview of the anti-inflammatory properties of olive oil in its topical application for various skin diseases and wounds. Methods. A literature search was conducted (1990–2021) in Medline, Embase, CINAHL, Google Scholar, Science Direct, SID, IranDoc, and Magiran databases. From the 102 reviewed articles, 17 articles were selected to be included in the current article. Results. Various forms of olive have long been used to accelerate the healing of various wounds and skin damage such as diabetic foot ulcers, atopic dermatitis, diaper dermatitis, episiotomy wound, and nipple ulcer but there are still no credible documents or articles that provide reliable evidence of topical use. Conclusion. According to the information obtained from the articles reviewed, olive oil appears to be an effective, safe, and available treatment. This study suggests that olive oil is an alternative remedy to minimize the frequent use of chemical-based treatments. More research may be beneficial to reach certainty in terms of curative properties of olive oil in similar or different injuries in different populations.

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Section: Topical Applications Of Olivementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Taheri

Amiri‐Farahani

2021

Dermatology Research and Practice

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“…Is the topical dose 2%w/w of AcOH optimal or could it be further improved by applying a different dose? The choice of 2% was not arbitrary, as acetic acid is usually used topically in doses ranging from 0.5 to 5%w/w and 2% is frequently applied topically for pseudomonas aeruginosa infections [40,41] . Another weakness is the non measurability of ILs characteristic of psoriasis like, IL17, IL17A, IL23 and TNF-α in the case of the hairless model ApoE/SKH-hr2.…”

Section: Based On Our Data (Figuresmentioning

confidence: 99%

Optimization of psoriasis mouse models

Karamani

Antoniadou

Dimou

et al. 2021

Journal of Pharmacological and Toxicological Methods

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Psoriasis, a common chronic, autoimmune, inflammatory, relapsing disease should benefit from reliable and human relevant animal models in order to pre-clinically test drugs and approach their mechanism of action. Due to ease of use, convenience and low cost, imiquimod (IMQ) induced psoriasis-like model is widely utilized; however, are all mouse strains equivalent, is the hairless mouse utilizable and can the imiquimod model be further optimized? Under similar experimental conditions, common mouse strains (BALB/c, C57BL/6J, ApoE) and a new hairless strain (ApoE/SKH-hr2) as well as several inducers (IMQ, IMQ + Acetic Acid (AcOH) topical and IMQ +AcOH systemic) were compared by clinical, histopathological, biophysical and locomotor activity assessment. Results showed that BALB/c mice yielded optimal psoriasislike phenotype with IMQ+AcOH topical treatment, C57BL/6J moderate, ApoE mild, while the ApoE/SKH-hr2 mice due to Munro abscess absence in histopathology analysis left doubts about the psoriasis-like acquisition. The locomotor activity of BALB/c mice treated with IMQ, IMQ+AcOH topically and IMQ+AcOH systemically, showed with all treatments, a decreased covered distance and rearing and an increased immobility. In conclusion, BALB/c appears an optimal psoriasis-like model when utilizing IMQ+AcOH topical application.

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“…Recent studies showed increased wound contraction and wound tensile strength when treated with extracts of Olea europaea [23]. In modern day studies, olive oil exhibited substantial wound healing efficacy in chronic wounds [24]. However, the antimicrobial capacity is limited [25].…”

Section: Plant-based Productsmentioning

confidence: 99%

Burn Care in the Greek and Roman Antiquity

et al. 2020

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The last century brought about more rapid new developments in the treatment of burns, which significantly lowered the mortality of burn injuries. However, burns were already treated in antiquity, where the threshold from spirituality to scientific medicine originated. The existing literature on burn treatment is very limited and there are many cross-references, some of them incorrect. The aim of this work by an interdisciplinary team of historians and physicians is to offer a more precise reproduction of the burn treatment of Greek and Roman antiquity using original texts in context and with a modern scientific background. There are many sources from ancient doctors on the subject of burn treatment, as well as the treatment of burned-out wounds and frostbite, which have not yet been mentioned. The literature research also showed an understanding of scientific contexts in ancient medicine, such as antiseptics or rheology. Interestingly, there was a change in burn medicine from everyday Greek medicine to Roman military medicine with other burn patterns. The care of patients using analgetics and the therapy of burn shock arose from the literature. The ancient world is considered to be the foundation of medicine, but it is believed to have been based mainly on shamanism rather than science. However, already more than two millennia ago, burns were correctly assessed and treated according to today’s scientific standards and scientific relationships were recognized.

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Efficacy of a Ceratothoa oestroides Olive Oil Extract in Patients With Chronic Ulcers: A Pilot Study

Cited by 9 publications

References 42 publications

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Optimization of psoriasis mouse models

Burn Care in the Greek and Roman Antiquity

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