Efficacy of a Lupinus mutabilis Sweet snack as complement to conventional type 2 diabetes mellitus treatment

Salvador, Marco Vinicio Fornasini; Abril-Ulloa, Victoria; Carreño, José Patricio Beltrán; Villacrés, Elena; Cuadrado-Merino, Lourdes; Robalino, Francisco; Sánchez, Rolando; Ortiz, Paul; Muñoz, Érika; Loza, Napoleón Benjamín Benítez; Baldeón, Manuel E.

doi:10.20960/nh.02590

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…The prospective urban rural epidemiology (PURE) study has shown in 18 low-middle income countries, not including Ecuador, that high consumption of legumes (3 to 4 servings/day) is associated with a 22% decrease in total-and non-cardiovascular mortality risks [10]. Our group has also shown that consumption of Lupinus mutabillis, an Andean legume commonly consumed in Ecuador, improves metabolic control in individuals with T2D, reducing serum concentrations of glycated hemoglobin and decreasing blood pressure [11]. In vitro studies show that L. mutabilis hypoglycemic effects could be attributed to the enzymatic inhibition of dipeptidyl peptidase-IV, inhibition of hepatic gluconeogenesis, and decreased insulin resistance [12].…”

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confidence: 73%

Prevalence of metabolic syndrome and diabetes mellitus type-2 and their association with intake of dairy and legume in Andean communities of Ecuador

et al. 2021

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Metabolic syndrome (MetS) and type 2 diabetes (T2D) are metabolic alterations associated with high morbidity and mortality, particularly in low and middle-income countries. Diet has a significant impact on the risk to develop MetS and T2D; in this regard, consumption of fruits, vegetables, and protein rich foods (from plant and animals) are important to prevent and manage these pathologies. There are limited studies regarding the potential association between Andean foods rich in proteins and the presence of cardio-metabolic conditions in Ecuador. It is necessary to develop new low-cost, local-culturally acceptable strategies to reduce the burden of cardio-metabolic diseases. We describe the prevalence (baseline data) of MetS and T2D in the Ecuadorian cohort of the Prospective Urban and Rural Epidemiology (PURE) study and their potential association with the consumption of protein rich foods, including beef, white meat, dairy and legumes. In this cross-sectional study, we assessed 1,997 individuals aged 35–70 years (mean age 51 years, 72% women), included in the Ecuadorian cohort of the PURE study, from February to December 2018. The prevalence of MetS was 42% for male and 44% for female participants; the prevalence of T2D was 9% for male and 10% for female. Metabolic syndrome and T2D were more common in women older than 50 years of age with primary education or less, low economic income, and with obesity; MetS was more frequent in the rural area while T2D was more frequent in the urban area. Using logistic regression analysis, we observed a significant protective effect of higher consumption of dairy and legumes in the prevalence of MetS and T2D compared with low consumption. It will be important to develop policies for ample production and consumption of protein rich foods such as legumes and dairy, part of traditional diets, to reduce the burden of cardio-metabolic diseases.

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Section: Introductionmentioning

confidence: 73%

Prevalence of metabolic syndrome and diabetes mellitus type-2 and their association with intake of dairy and legume in Andean communities of Ecuador

et al. 2021

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Physical properties, sensory acceptance, postprandial glycemic response, and satiety of cereal based foods enriched with legume flours: a review

Binou

Yanni

Karathanos

2020

Critical Reviews in Food Science and Nutrition

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Superfoods for Type 2 Diabetes: A Narrative Review and Proposal for New International Recommendations

Pires

2023

Medicina

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Background and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease affecting an estimated 537 million individuals worldwide. ‘Superfoods’ can be integrated into the diet of T2DM patients due to their health benefits. Study Objectives: (i) To carry out a narrative review of ‘superfoods’ with the potential to reduce glycaemic levels in T2DM patients (2019 to 2022), (ii) to identify ‘superfoods’ with the potential to reduce HbA1c and (iii) to propose new guidance on the use of ‘superfoods’. Materials and Methods: A narrative review was carried out using the databases PubMed, SciELO, DOAJ and Google Scholar. The keywords were [“type 2 diabetes” and (“food” or “diet” or “nutrition”) and (“glycaemia” or “glycemia”)]. Only review studies were included. Results: Thirty reviews were selected. The ‘superfoods’ identified as having a potential impact on glycaemic control were foods with polyphenols (e.g., berries), fermented dairy products, whole cereals/grains, nuts and proteins, among others. The possibility of an extensive reduction in Hb1Ac was reported for fermented dairy products, especially yoghurts enriched with vitamin D or probiotics (HbA1c reduction of around 1%) or by increasing the fibre intake by 15 g (or up to 35 g) (HbA1c reduction of around 2%). Conclusion: It is recommended that the identified ‘superfoods’ are included in the diet of T2DM patients, although this should not substitute an appropriate diet and exercise plan. In particular, yoghurts and an increased fibre intake (by 15 g or up to 35 g) can be used as nutraceuticals. New recommendations on the introduction of ‘superfoods’ in the diet of T2DM patients have been proposed.

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Efficacy of a Lupinus mutabilis Sweet snack as complement to conventional type 2 diabetes mellitus treatment

Cited by 5 publications

References 41 publications

Prevalence of metabolic syndrome and diabetes mellitus type-2 and their association with intake of dairy and legume in Andean communities of Ecuador

Prevalence of metabolic syndrome and diabetes mellitus type-2 and their association with intake of dairy and legume in Andean communities of Ecuador

Physical properties, sensory acceptance, postprandial glycemic response, and satiety of cereal based foods enriched with legume flours: a review

Superfoods for Type 2 Diabetes: A Narrative Review and Proposal for New International Recommendations

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