Efficacy of a Metered-dose 8% Lidocaine Pump Spray for Patients with Post-herpetic Neuralgia

Kanai, Akifumi; Kumaki, Chie; Niki, Yuriko; Suzuki, Asaha; Tazawa, Toshiharu; Okamoto, Hirotsugu

doi:10.1111/j.1526-4637.2009.00662.x

Cited by 22 publications

(18 citation statements)

References 19 publications

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“…A difference of 3 cm of VAS score was considered clinically significant [17]. Based on a preliminary examination, we estimated the within-group standard deviation for VAS score of 2.5 cm.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravenous Prostaglandin E1 on Pain and Body Temperature in Patients with Post-Herpetic Neuralgia

Kanai¹,

Wang

Hoshi

et al. 2010

Pain Med

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Objective. Bathing, heating, or sympathetic blockade often alleviates pain due to post-herpetic neuralgia (PHN), suggesting that blood flow may affect PHN pain. Here, we examined the effect of prostaglandin E1 (PGE), which improves blood circulation, on pain and body temperature in patients with PHN.Design. Twenty-four patients with PHN were enrolled in a randomized, double-blind, placebocontrolled, crossover study. After 30-minute rest in a temperature-controlled (20°C) and intravenous cannulation, patients were randomized to receive either 60 mg of PGE dissolved in 100 mL of saline, or 100 mL of saline at an infusion rate of 0.03 mg/kg/ min. Following a 7-day washout period, patients were crossed over to receive the other treatment. The visual analog scale (VAS) of ongoing pain and tactile allodynia, and skin and the tympanic temperatures were measured before and after infusion.Results. The two solutions significantly decreased the VAS for ongoing pain, and the reduction was greater with PGE than placebo (P < 0.05). Although the temperatures of the forehead, hand, foot, chest, abdomen, and the most painful region were significantly increased in the two solutions, the elevation in the foot and the most painful region was greater with PGE than placebo (P < 0.01). The tympanic temperature did not significantly change following infusion of PGE.Conclusions. Intravenous infusion of PGE produces analgesia associated with elevation of skin temperature in patients with PHN.

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“…A difference of 3 cm of VAS score was considered clinically significant [17]. Based on a preliminary examination, we estimated the within-group standard deviation for VAS score of 2.5 cm.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intravenous Prostaglandin E1 on Pain and Body Temperature in Patients with Post-Herpetic Neuralgia

Kanai¹,

Wang

Hoshi

et al. 2010

Pain Med

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“…[119] Lidocaine has also been used as a topical spray for dressing changes, for pain associated with peripheral blood flow disorders, and post herpetic neuralgia. [121][122][123] Safety issues have been considered in a 2002 pharmacokinetic study that considered the 5% lidocaine patch to be safe, only causing mild skin erythema and low plasma lidocaine levels [124], but a single case report has concluded that lidocaine toxicity is possible when multiple forms of topical application are used. [125] Topical non-steroidal anti-inflammatory drugs (NSAIDs): Extracts from willow trees and other salicylate containing plants also have their origins in antiquity, possibly dating back to the Sumerians and ancient Egyptians in the treatment of fevers.…”

Section: Facit Ad Maximos Dolores -Useful For Extreme Painmentioning

confidence: 99%

Topical Treatment in Pain Medicine: From Ancient Remedies to Modern Usage

Finch¹,

Drummond

2015

Pain Manag.

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Abstract:Over several millennia, substances have been applied to the skin for treatment of pain. Some ingredients are in current use; others have been discontinued.Mechanisms of action include interactions with nociceptive neural networks and inflammatory processes. Substances must penetrate the stratum corneum barrier and vehicles that enhance penetration have been developed. Topical drugs with links to the past include menthol, capsaicin, some opioids, local anaesthetic agents and non-steroidal anti-inflammatory drugs. Mandragora is also described as an example of a herbal remedy that has been discontinued due to its toxicity. The future for topical drugs is promising, with the advent of new drugs tailored for specific pain mechanisms and the development of both penetration enhancers and sterile preparation methods.

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“…A metered‐dose pump of 8% lidocaine (LDC; Xylocaine pump spray ® , Astra Zeneca, Osaka, Japan) is commercially available and mainly used for anesthetizing mucosal membranes, e.g., preparation of the upper airway for endoscopy. This preparation includes flavor and fragrance, and can be easily used for intraoral applications [6,7]. To test our hypothesis, we examined in a double‐blind, placebo ( PBO )‐controlled crossover study the efficacy of intraoral LDC in the relief of oral pain in patients with TN.…”

Section: Introductionmentioning

confidence: 99%

Immediate Analgesic Effect of 8% Lidocaine Applied to the Oral Mucosa in Patients with Trigeminal Neuralgia

et al. 2014

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Efficacy of a Metered-dose 8% Lidocaine Pump Spray for Patients with Post-herpetic Neuralgia

Abstract: In both studies, XPS provided a significant improvement in PHN due to its prompt analgesia, lack of systemic side effects, and convenience of use.

Cited by 22 publications

References 19 publications

Effects of Intravenous Prostaglandin E1 on Pain and Body Temperature in Patients with Post-Herpetic Neuralgia

Effects of Intravenous Prostaglandin E1 on Pain and Body Temperature in Patients with Post-Herpetic Neuralgia

Topical Treatment in Pain Medicine: From Ancient Remedies to Modern Usage

Immediate Analgesic Effect of 8% Lidocaine Applied to the Oral Mucosa in Patients with Trigeminal Neuralgia

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