2018
DOI: 10.3390/nu10050528
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Efficacy of a Moderately Low Carbohydrate Diet in a 36-Month Observational Study of Japanese Patients with Type 2 Diabetes

Abstract: We previously showed that a non-calorie-restricted, moderately low-carbohydrate diet (mLCD) is more effective than caloric restriction for glycemic and lipid profile control in patients with type 2 diabetes. To determine whether mLCD intervention is sustainable, effective, and safe over a long period, we performed a 36-month observational study. We sequentially enrolled 200 patients with type 2 diabetes and taught them how to follow the mLCD. We compared the following parameters pre- and post-dietary intervent… Show more

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Cited by 15 publications
(31 citation statements)
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“…All 12 single‐arm and non‐randomized trials found that a low‐carbohydrate diet significantly improved glycaemic control from baseline to end of study; the two studies that made between‐group comparisons found the low‐carbohydrate diet superior to the control diet . We identified eight longer‐term studies (1‐3 years' duration), of which five found significant glycaemic benefit sustained with a low‐carbohydrate diet; these include two 2‐year trials and a 3‐year trial . Another longer trial also found sustained improvement in glycaemic control at 44 weeks .…”
Section: Resultsmentioning
confidence: 99%
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“…All 12 single‐arm and non‐randomized trials found that a low‐carbohydrate diet significantly improved glycaemic control from baseline to end of study; the two studies that made between‐group comparisons found the low‐carbohydrate diet superior to the control diet . We identified eight longer‐term studies (1‐3 years' duration), of which five found significant glycaemic benefit sustained with a low‐carbohydrate diet; these include two 2‐year trials and a 3‐year trial . Another longer trial also found sustained improvement in glycaemic control at 44 weeks .…”
Section: Resultsmentioning
confidence: 99%
“…Another longer trial also found sustained improvement in glycaemic control at 44 weeks . All of these studies assessed HbA1c as the primary glycaemic marker, except the study by Dashti et al, which only reported FBG.…”
Section: Resultsmentioning
confidence: 99%
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