Efficacy of a novel formulation of metaflumizone plus amitraz for the treatment of sarcoptic mange in dogs

Fourie, L.J.; Kok, D. J.; Plessis, A. du; Rugg, Douglas

doi:10.1016/j.vetpar.2007.08.046

Cited by 28 publications

(45 citation statements)

References 7 publications

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“…In dogs fitted with an imidacloprid/flumethrin collar, the parasitological cure was reported after 3 months in a laboratory study [ 24 ]. In several studies, either no control group was included [ 14 , 24 ] or a positive control product was used [ 13 ]. In the laboratory studies that used placebo-treated [ 21 ] or untreated control animals [ 15 ], a decrease in mite counts was reported in the control animals during the study period.…”

Section: Discussionmentioning

confidence: 99%

“…There are various topical and systemic therapies currently used for the treatment of sarcoptic mange in dogs [ 4 , 7 ], either by contact activity onto the skin (e.g. amitraz dips; fipronil spray, metaflumizone/amitraz spot-on formulation, imidacloprid/flumethrin collar; or fipronil/amitraz/S-methoprene spot-on formulation) [ 6 , 8 , 14 , 15 , 16 , 19 , 20 , 24 ], or through systemic activity (e.g. selamectin and moxidectin/imidacloprid spot-on formulation having transcutaneous absorption) [ 13 , 17 , 21 , 23 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of afoxolaner in a clinical field study in dogs naturally infested withSarcoptes scabiei

et al. 2016

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The acaricidal efficacy of afoxolaner (NexGard®, Merial) was evaluated against Sarcoptes scabiei var. canis in a field efficacy study, when administered orally at a minimum dose of 2.5 mg/kg to dogs naturally infested with the mites. Twenty mixed-breed dogs of either sex (6 males and 14 females), aged over 6 months and weighing 4–18 kg, were studied in this randomised controlled field efficacy trial. Dogs, naturally infested with Sarcoptes scabiei var. canis confirmed by skin scrapings collected prior to allocation, were randomly divided into two equal groups. Dogs in Group 1 were not treated. Dogs in Group 2 were treated on Days 0 and 28. On Days 0 (pre-treatment), 28 (pre-treatment) and 56, five skin scrapings of similar size were taken from different sites with lesions suggestive of sarcoptic mange. The extent of lesions was also recorded on Days 0, 28 and 56, and photographs were taken. Dogs treated orally with afoxolaner had significantly (p < 0.001) lower mite counts than untreated control animals at Days 28 and 56 with no mites recovered from treated dogs at these times (100% efficacy based on mite counts). In addition, dogs treated with NexGard had significantly (p < 0.05) better lesion resolution at Day 56 than Day 0; no treated dog showed pruritus compared to 7/10 dogs in the control group, 1/9 treated dogs had crusts compared to 5/10 controls and 8/9 dogs recovered 90% of hairs on lesions compared to 0/10 control dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of afoxolaner in a clinical field study in dogs naturally infested withSarcoptes scabiei

et al. 2016

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“…Currently available licensed therapeutic options for sarcoptic mange may include the active compounds selamectin [ 12 ], imidacloprid/moxidectin [ 13 ] and in some countries amitraz [ 14 ], which are administered topically. A recent therapeutic option in some areas is oral treatment with the isoxazoline sarolaner.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fluralaner administered either orally or topically for the treatment of naturally acquired Sarcoptes scabiei var. canis infestation in dogs

et al. 2016

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BackgroundThe efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. canis infestation in dogs.MethodsThe study was performed in privately-owned dogs naturally infested with S. scabiei var. canis. All dogs living in the same household as the infested dog were enrolled into one of 3 groups (2 fluralaner treated and 1 negative control). All dogs within one household were administered the same treatment, with one dog per household included in further observations and assessments. In total, 29 dogs confirmed positive for sarcoptic mange were included. On Day 0, all dogs in group 1 (n = 9) were treated once orally with fluralaner at a minimum dose of 25 mg/kg body weight; all dogs in group 2 (n = 11) were treated once topically with fluralaner at a dose of 25 mg/kg body weight; and dogs in group 3 (n = 9) were treated once topically with saline solution. Sarcoptes scabiei var. canis mites on each dog were counted before treatment and at 4 weeks after treatment in deep skin scrapings (~4 cm2) from 5 different body areas. Clinical signs of infestation (i.e. erythematous papules; casts, scales and crusts; body areas with hair loss) and pruritus were recorded at the same time points.ResultsSingle oral or topical treatment with fluralaner resulted in a 100 % reduction in mite counts post-treatment (group 1: P = 0.0009 and group 2: P = 0.0011). Resolution of clinical signs at four weeks post-treatment was variable, with improvement observed for erythematous papules, casts and crusts, and pruritus. All fluralaner treated dogs showed an improvement in overall hair re-growth compared with pre-treatment observations.ConclusionFluralaner administered either orally or topically to naturally infested dogs eliminates Sarcoptes scabiei var. canis mites and improves clinical signs over a 4-week observation period.

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“…Systemically acting macrocyclic lactones, such as ivermectin, milbemycin oxime, moxidectin, and selamectin, have been used successfully for control of canine sarcoptic mange. Efficacy of such treatments (based on mite counts and/or clinical signs) can vary considerably ranging from 60% to 100% (Fourie et al 2007). Furthermore, with the exception of selamectin, these drugs are not licensed for the treatment of sarcoptic mange.…”

Section: Resultsmentioning

confidence: 99%

Neem seed extract shampoo, Wash Away Louse®, an effective plant agent against Sarcoptes scabiei mites infesting dogs in Egypt

et al. 2008

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In the present study, the efficacy of water-free neem seed extract shampoo Wash Away Louse, provided by Alpha-Biocare GmbH, Düsseldorf (Germany), was investigated against Sarcoptes scabiei infesting dogs in Egypt. Ten naturally infested dogs were collected from different areas in the Nile delta. The occurrence of lesions, hair loss, and skin inflammation were regarded as signs of infestation and proved by detection of adult parasites and their developmental stages in scrapings of infested lesions. Adequate amount of the provided shampoo was applied topically and spread on the infested areas daily for 14 successive days. Scraping examinations were used to follow up the healing process. At day 7 of application, four dogs were completely free of mites as was proven by the disappearance of adults and/or any developmental stages of mites. The remaining six dogs showed a clear decrease in mite counts. By the end of the treatment (after 14 days), only a small number of mites were found in two dogs, while eight dogs were completely cured as was proven by mite counts and disappearance of clinical signs. No remarkable signs of side effects or adverse reactions were observed throughout the study.

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Efficacy of a novel formulation of metaflumizone plus amitraz for the treatment of sarcoptic mange in dogs

Cited by 28 publications

References 7 publications

Efficacy of afoxolaner in a clinical field study in dogs naturally infested withSarcoptes scabiei

Efficacy of afoxolaner in a clinical field study in dogs naturally infested withSarcoptes scabiei

Efficacy of fluralaner administered either orally or topically for the treatment of naturally acquired Sarcoptes scabiei var. canis infestation in dogs

Neem seed extract shampoo, Wash Away Louse®, an effective plant agent against Sarcoptes scabiei mites infesting dogs in Egypt

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