Efficacy of a novel inactivated Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

Jacobs, A. A. C.; Harks, F.; Hazenberg, L.; Hoeijmakers, M.J.H.; Nell, T.; Pel, Sara; Segers, R. P. A. M.

doi:10.1016/j.vaccine.2019.02.067

Cited by 19 publications

(28 citation statements)

References 9 publications

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“…Given the nature of PPE, being a local intestinal infection, one would expect an attenuated live vaccine administered orally to be protective rather than an inactivated vaccine that is administered systemically. In this study we demonstrate however that an inactivated vaccine administered intradermally is highly efficacious against L. intracellularis infection which is in line with previous results of Jacobs et al [6] and Roerink et al [7] who also showed good protection against experimental L. intracellularis infection using inactivated whole cell vaccines. Although the exact protective mechanism is not known, and opposite to the general immunological understanding, the inactivated vaccine protected much better compared to a commercially available live vaccine.…”

Section: Discussionsupporting

confidence: 93%

“…In a previous study we reported the efficacy of a novel vaccine for intramuscular use, Porcilis® Lawsonia [6]. This vaccine consists of a freeze-dried L. intracellularis antigen fraction that is dissolved in adjuvant just before intramuscular use.…”

Section: Discussionmentioning

confidence: 99%

“…Although both inactivated and live attenuated vaccines are being used in the pig industry against the disease [6,7](http://www.enteric.solutions/), no intradermal vaccines have been available until now. Intradermal (ID) vaccination has the advantage of targeting antigen presenting cells in the epidermis in close proximity to skin-draining lymph nodes [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Recently we reported on the efficacy of a new inactivated one dose vaccine against L. intracellularis consisting of inactivated freeze-dried bacterial antigen that just before use is reconstituted in either its own adjuvant or in Porcilis® PCV M Hyo; an existing combination vaccine against porcine Circovirus type 2 and Mycoplasma hyopneumoniae [6]. A logical approach for the development of a new intradermal vaccine is to dissolve the same freeze-dried antigen fraction in an intradermal adjuvant (= Porcilis® Lawsonia ID).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a novel intradermal Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

et al. 2020

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Background The efficacy of a novel inactivated intradermal Lawsonia intracellularis vaccine, Porcilis® Lawsonia ID, was evaluated in two experimental vaccination-challenge studies and under field conditions on a farm with a history of recurrent acute ileitis. In addition, the efficacy of the vaccine was compared to that of a commercially available live attenuated vaccine. The novel inactivated vaccine consists of a freeze-dried antigen fraction that is dissolved just prior to use in either the adjuvant or in Porcilis® PCV ID; an existing intradermal vaccine against porcine Circovirus type 2. In the two experimental vaccination-challenge studies, groups of 25 piglets were vaccinated once at 3 weeks of age or left unvaccinated as challenge control. Vaccines tested were Porcilis® Lawsonia ID as standalone (study 1) or in associated mixed use with Porcilis® PCV ID (study 2) and an orally administered commercially available live vaccine (study 1). The pigs were challenged with virulent L. intracellularis at 4 weeks (study 1) or 21 weeks (study 2) after vaccination. Post-challenge, the pigs were evaluated for clinical signs, average daily weight gain, shedding and macroscopic as well as microscopic immuno-histological ileum lesion scores. In the field study, the mortality and key performance parameters were evaluated over a period of 8 months. Results The results of the two experimental vaccination-challenge studies showed that Porcilis® Lawsonia ID as single vaccine or in associated mixed use with Porcilis® PCV ID, induced statistically significant protection against experimental L. intracellularis infection, 4 weeks or 21 weeks after vaccination. This was demonstrated by lower clinical scores, improved weight gain, reduction of L. intracellularis shedding and reduction of macroscopic as well as microscopic ileum lesion scores when compared to the controls. The protection induced was superior to that of the commercially available live vaccine. In the field study Porcilis® Lawsonia ID was highly efficacious in reducing L. intracellularis associated mortality and improving key production parameters. Conclusion The results support that this new intradermal vaccine is efficacious against L. intracellularis and may be used in associated mixed use with Porcilis® PCV ID.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of a novel intradermal Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

et al. 2020

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“…Dawkę 2 ml można podawać od 3. tygodnia życia prosiąt -po zaszczepieniu odporność uzyskuje się po 4 tygodniach, a czas jej trwania wynosi 21 tygodni od momentu zaszczepienia. Szczepienie w formie iniekcyjnej pozwala na otrzymanie dokładnej objętości dawki szczepionki, a tym samym odpowiedniej ilości antygenu potrzebnego do wywołania odpowiedzi immunologicznej chroniącej wszystkie immunizowane zwierzęta (6).…”

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Vaccines in control of infectious diseases of swine

Tarasiuk¹

2021

Medycyna Weterynaryjna

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The study presents data concerning vaccines registered in the EU that are used in the prevention and control of viral and bacterial infectious diseases of swine in Poland. It discusses novel vaccines against infectious diseases of swine, such as ileitis, influenza A virus, and mycoplasmal pneumonia. The advantages of intradermal administration of selected vaccines against certain diseases are discussed. Selected problems regarding the efficacy of vaccination against influenza A virus and PRRS are underlined. The study points out that the efficacy of immunization with inactivated vaccines against PRRS is limited. This, however, may also be true of live vaccines against PRRS, since results of immunization with some live attenuated vaccines can be unsatisfactory as well. It is explained by the fact that there are relatively frequent genetic changes in the genome of the field PRRSV strains, unlike in the virus strain or strains used in the vaccine. Strategies to optimize the use of currently available vaccines against influenza A virus (IAV) are discussed. It is worth noting the high efficacy of the vaccine containing antigens of subtypes H1N1, H3N2, and H1N1 against influenza A virus. Vaccination against IAV induces the production of neutralizing antibodies and protection with a very similar strain. As far as vaccines against viral diseases of swine (pseudorabies, classical swine fever) are concerned, the marker vaccines appear to be very useful in differentiating infected animals from vaccinated ones (DIVA strategy). At the beginning of the 21st century, several new effective vaccines were developed, produced, and used against diarrheal diseases of different etiology and, for the first time, against oedema disease, ileitis, and enzootic pneumonia of swine. In view of the growing problem of mixed infections, the study presents several new vaccines containing multiple antigens of one pathogen (serotypes/genotypes) or different pathogens in combination (polyvalent vaccines). The study also discusses the role of the strategy of vaccination depending on the course of the infectious disease, the type of vaccine, as well as the production system of swine.

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Campylobacter– Hyperendemic on the Farm

2023

Fundamentals of Veterinary Microbiology

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Efficacy of a novel inactivated Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

Cited by 19 publications

References 9 publications

Efficacy of a novel intradermal Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

Efficacy of a novel intradermal Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

Vaccines in control of infectious diseases of swine

Campylobacter– Hyperendemic on the Farm

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