Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer

Timur, Selin Seda; Yöyen-Ermiş, Diğdem; Esendağlı, Güldal; Yonat, Selcen; Horzum, Utku; Esendağlı, Güneş; Gürsoy, R. Neslihan

doi:10.1016/j.ejpb.2019.01.017

Cited by 31 publications

(11 citation statements)

References 57 publications

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“…MLP was added to the formulations by simply mixing until a homogenous mixture was obtained. All the formulations were kept for 24 h at ambient temperature to reach equilibrium before transport studies and diluted with transport media prior to the application [15] , [16] . The formulations were assessed in terms of organoleptic properties, as well as droplet size and zeta potential values were obtained.…”

Section: Methodsmentioning

confidence: 99%

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

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Timur

Erdoğan

et al. 2022

Journal of Pharmaceutical and Biomedical Analysis

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Section: Methodsmentioning

confidence: 99%

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

Reçber

Timur

Erdoğan

et al. 2022

Journal of Pharmaceutical and Biomedical Analysis

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“…Also, in comparison to free drugs, SMEDDS showed reduced tumor growth and metastasis. Hence, SMEDDS could be served as a therapeutic platform for combination drug delivery via the lymphatic pathway for the treatment of TNBC [ 293 ]. Kim et al, 2019, fabricated decitabine (DAC) and panobinostat (PAN) co-loaded lipid nanoemulsion (LNEs) for the treatment of TNBC.…”

Section: Nanotechnology: Cavalry For Tnbc Therapymentioning

confidence: 99%

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

et al. 2022

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Triple-negative breast cancer (TNBC) is considered one of the un-manageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ability of recurrence and metastasis, the management of TNBC remains a mainstay challenge, despite the advancements in cancer therapies. Conventional chemotherapy remains the only treatment regimen against TNBC and suffers several limitations such as low bioavailability, systemic toxicity, less targetability, and multi-drug resistance. Although various targeted therapies have been introduced to manage the hardship of TNBC, they still experience certain limitations associated with the survival benefits. The current research thus aimed at developing and improving the strategies for effective therapy against TNBC. Such strategies involved the emergence of nanoparticles. Nanoparticles are designated as nanocavalries, loaded with various agents (drugs, genes, etc.) to battle the progression and metastasis of TNBC along with overcoming the limitations experienced by conventional chemotherapy and targeted therapy. This article documents the treatment regimens of TNBC along with their efficacy towards different subtypes of TNBC, and the various nanotechnologies employed to increase the therapeutic outcome of FDA-approved drug regimens.

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“…A fixed quantity of isotropic admixture is diluted with double purified water to yield a clear emulsion [19,20]. The resulting emulsions can be inspected outwardly for their relative polluting influence and their transmittance can be evaluated in UV-visible spectrophotometer with the help of double purified water as the blank [21][22][23].…”

Section: Composition Of Smedsmentioning

confidence: 99%

Review of formulation and evaluation of self-micro emulsifying drug delivery system (SMEDDS)

Bahadur¹,

Yadu²,

Baghel³

et al. 2020

ScienceRise: Pharmaceutical Science

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Approximately half of the new drug applicants that reach formulation have poor water solubility. Oral delivery has been the main route of drug administration for the chronic treatment of numerous diseases. In different cases, in oral conveyance, 50 % of the medication compound is hampered because of the high lipid soluble or fat soluble of the medication itself. Around 40 % of new drug applicants show low solubility in water, which prompts poor oral bioavailability, high Intra and Intersubject changeability, and deficiency of dose proportionality Aim of review. The main aim of this review article is to gather the information related to design and evaluation of SMEDDS. These information can be utilized to enhance the bioavailability of the poorly aqueous soluble drug for various types of orally administered drugs. In this review article, various literature are reviewed and summerised in single paper to serve as reference guide to various research scholars and researchers working on self-micro-emulsifying drug delivery systems. Materials and Methods. To prepare this manuscript various keywords were searched in different search engine such as Google, Yahoo and Bing etc. This review article reviews the recent work done in the field of SMEDDS. It comprises review of literatures available in public domain and formulation of SMEDDS and its characterization is summarized in this article. Result. The various strategies to developed poor aqueous soluble drug for improvement of bioavailability for example, salt development and molecular size reduction of the compound might be one technique to enhance the dissolution rate of the drug. In any case, these methods have their limitations. SMEDDS is one of the novel applications for the delivery of low water soluble and low bioavailability of drug. SMEDDS is a method to improve the aqueous solubility of the medication; SMEDDS are described as isotropic blenders of oils, surfactants, and co-surfactant. Upon slightly stir followed by dilution with distilled water, for example, gastrointestinal liquids, these techniques can define clear o/w micro emulsion. SMEDDS is first choice and key technology for developing the lipophilic drug and other different factors that chance to affect the oral bioavailability. Conclusions. This review paper attempts to describe the preparation of SMEDDS and furthermore discusses the development of pseudo ternary phase diagram for SMEDDS. It describes the mechanism and method of preparation involved in SMEDDS. The capability of oral absorption of drug compound from the SMEDDS relies upon numerous formulation−related parameters, for example, surfactant concentration, oil/surfactant ratio, and hydrophobicity of emulsion, globule size and charge, in vitro, in vivo all of which basically characterized the ability of self-emulsification. SMEDDS are administered as unit dosage form and it also protect the degradation of drug.

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Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer

Cited by 31 publications

References 57 publications

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

Review of formulation and evaluation of self-micro emulsifying drug delivery system (SMEDDS)

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