Efficacy of a polyherbal formulation in the treatment of SARS CoV-2 disease: An open labelled feasibility study

Abstract

Background: The ongoing pandemic caused by human coronavirus SARS CoV-2 has led to millions of death across the globe. Not only the virus is highly infectious, it is also mutates very easily. Currently there are no approved drugs for the therapeutic cure of COVID-19. The world is in search for an alternative that has antiviral properties directed against virus. Objective: The present study investigates an Ayurvedic polyherbal formulation of 13 herbs, named NOQ19, targeted against various viral proteins of COVID-19. Methodology: The study is a single arm, single centric, open label study of 161 RT-PCR positive COVID-19 patients. The enrolled participants were given the ayurvedic intervention, 2 tablets, thrice daily, to be consumed along with the standard care. Follow up COVID-19 RT- PCR was done on Day 5, Day 10 and Day 14 or until the patient turned negative. The time required for turning RT-PCR negative or become asymptomatic was noted. Results: Subjective analysis demonstrated that 98% of patients turned asymptomatic within 5 days of NOQ19 intake. Also 74% of the subjects turned RT-PCR Negative on Day 5 after taking NOQ19 along with the standard care provided. Also, none of the participant reported any adverse effect or side effect to the medication.Conclusion: NOQ19 Ayurvedic polyherbal formulation is an effective as well as safe alternative and adjunct treatment for the symptomatic management of COVID-19.

An integrative approach to clinical recovery for COVID-19 patients using an Ayurvedic formulation: A multicentric double-blind randomized control trial.

“…The study showed a 74% rate of recovery among the COVID-19 patients after 5 days of NOQ19 consumption 25 .…”

“…Previous studies on the same formulation NOQ19 have shown promising results with respect to rate of recovery and antiviral e cacy [23][24][25] . A review of Ayurvedic literature presents robust preclinical evidence for e cacy of multiple NOQ19 ingredients such as Ashwagandha (Withania somnifera) and Guduchi (Tinospora cordifolia), along with Amalaki (Phyllanthus emblica) in proliferation of B and T cells and activation of nonspeci c immunity 32 .…”