Efficacy of a single dose of antenatal steroid in surfactant-treated babies under 31 weeks' gestation

Effect of antenatal corticosteroid on early neonatal outcome in preterm neonates: a prospective observational study

“…Studies done by Wang YC, Tseng HI and Sen S, Reghu showed similar results in which preterms who were born to mothers who have received ACS with gestational age between 24 weeks +6 days and 34 weeks had lesser incidence of respiratory distress syndrome as well as requirement of surfactant and CPAP. 6,7 Need of surfactant and CPAP ventilation was less in comparison to neonates born to mothers who have received multiple doses of ACS. This was comparable to results observed in the study done by Wapner RJ, Sorokin Y, Mele L et al 8 There was no statistical significance in reduction of incidence of PDA, necrotizing enterocolitis (P=0.467) and sepsis (P=0.107) in neonates born to mothers who have received ACS, similar results were observed in a study conducted by Wang YC, Tseng HI.…”

Use of Antenatal Corticosteroids in the Management of Preterm Delivery

“…Retrospective studies evaluating the effectiveness of an incomplete course in preterm neonates born before being given a second dose have shown inconsistent results. [27][28][29][30][31][32] In some studies, ACS reduced neonatal death after exposure to a single dose, 5 and was found to be associated with significant reductions in morbidities. 27,29 Other studies could not find such a benefit.…”

“…27,29 Other studies could not find such a benefit. 32 When compared with infants exposed to a complete course, those exposed to a single dose had similar outcomes, 30,31 except for a higher neonatal death rate at 24 to 27 weeks gestational age (GA). 28 In one randomized trial, infants at 34 to 36 weeks GA exposed to a single dose had lower rates of RDS compared with unexposed.…”

Factores de riesgo en la mortalidad de los recién nacidos de muy bajo peso con membrana hialina

“…La introducción en la clínica de la terapia con agente tensioactivo parece haber supuesto un beneficio para estos pacientes, así como la terapia con corticoides prenatales [7][8][9][10][11][12][13][14] . A pesar de la afluencia en la literatura especializada de numerosas publicaciones respecto a la administración de agente tensioactivo exógeno, existen pocos trabajos planteados de una forma similar a la que aquí se presenta, ya que en realidad existen pocas publicaciones científi-cas que analicen las épocas pre y postagente tensioactivo 15 .…”

“…Nuestros resultados coinciden con diversos trabajos publicados en la literatura especializada en cuanto al beneficio aditivo entre la terapia con agente tensioactivo y corticoides prenatales [7][8][9][10][11][12][13][14] , incluso cuando se estudian en el contexto de una metodología multifactorial, como ocurre en este trabajo en concreto, en el que además aparecen significativas otras variables mencionadas como el bajo peso al nacimiento, el test de Apgar bajo al quinto minuto y la gravedad de la EMH. En cambio, el test de Apgar al primer minuto no adquiere valor en el modelo de mortalidad final, lo que indica la importancia de la reanimación.…”