Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study

Clementi, Daniele; D’Ambrosi, Riccardo; Bertocco, P.; Bucci, M.; Cardile, Carlo; Ragni, P; Giaffreda, Graziella; Ragone, Vincenza

doi:10.1007/s00590-017-2083-9

Cited by 29 publications

(37 citation statements)

References 27 publications

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“…To the Editor, We read with great interest the study by Clementi et al [1] that would like to explore the efficacy of a single intraarticular injection of ultra-high molecular weight hyaluronic acid in patients with hip osteoarthritis. Actually, we believe that investigating just patients' clinical status using VAS and WOMAC scale should have been supported by further information.…”

mentioning

confidence: 99%

Comment on “Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study”

Santilli

Alviti

Paoloni

et al. 2018

Eur J Orthop Surg Traumatol

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confidence: 99%

Comment on “Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study”

Santilli

Alviti

Paoloni

et al. 2018

Eur J Orthop Surg Traumatol

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“…58 Despite the widespread use of hip injections, there are no universally agreed upon algorithms or specific injectates used for hip OA. [59][60][61][62][63][64][65][66][67][68] If the possibility of infection has been excluded, a common approach is to start with an intraarticular hip steroid injection or combination of steroid and anesthetic. If there is pain relief, this indicates the hip (and not a referred source such as the spine) is the culprit.…”

Section: Image-guided Injectionsmentioning

confidence: 99%

“…[59][60][61][62] If hip pain responders are referred for additional treatments, injectates such as hyaluronic acid (HA), platelet-rich plasma (PRP), stem cells, or polynucleotides may be considered. [63][64][65][66][67][68] However, more prospective randomized trials that assess the long-term success in the hip are needed.…”

Section: Image-guided Injectionsmentioning

confidence: 99%

“…63 Similar to fluoroscopy, studies on sonographic-guided HA injections presented that it is a safe procedure with good pain relief even at a 7-year follow-up with six monthly HA injections. [65][66][67] In the case of only one HA injection, pain reduction was maintained up to a year. 67 PRP, stem cell therapy, and polynucleotide injections are being utilized with the goal of promoting joint repair and pain relief.…”

Section: Image-guided Injectionsmentioning

confidence: 99%

“…[65][66][67] In the case of only one HA injection, pain reduction was maintained up to a year. 67 PRP, stem cell therapy, and polynucleotide injections are being utilized with the goal of promoting joint repair and pain relief. 68 Prospective randomized studies will be needed to assess their long-term effectiveness.…”

Section: Image-guided Injectionsmentioning

confidence: 99%

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Standard and Advanced Imaging of Hip Osteoarthritis. What the Radiologist Should Know

Huang

Tan

Scherer

et al. 2019

Semin Musculoskelet Radiol

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Osteoarthritis (OA) of the hip is caused by degeneration of articular cartilage and the underlying bone and can be divided into two types: primary (associated with advancing age) and secondary (subsequent to fractures, avascular necrosis, infection, developmental dysplasia, and femoroacetabular impingement). Radiography remains the first-line imaging modality for diagnosing and monitoring OA, due to its accessibility, low cost, and ease of interpretation. Kellgren-Lawrence and Tönnis classification systems are radiographic OA grading systems used primarily in research, and they reflect the degree of joint space narrowing, sclerosis, cysts, deformity of the femoral head and acetabulum, and osteophytes. Unenhanced computed tomography (CT) provides detailed visualization of the hip joint segments that may be difficult to appreciate on radiographs, such as the inferoposterior and posterolateral hip joint. CT arthrography, magnetic resonance imaging (MRI), and magnetic resonance arthrography with two-dimensional reconstructions can delineate labral abnormalities, cartilage lesions, and other intra-articular hip pathology. T2 and T2* mapping, delayed gadolinium-enhanced MRI of cartilage, T1rho, ultra-short echo time, and zero echo time are investigative MR techniques with promising evaluation of hip OA.

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Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review

et al. 2022

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Osteoarthritis (OA) is a progressive degenerative disease that causes severe pain and functional limitation, especially during locomotion. It is the most common arthritis type that damages the surface of articular cartilage until the underlying bone. In the past decade, the scientific community has made a considerable effort to improve or discover therapeutical products used as a form of conservative treatment capable of restoring the damaged articular tissue, avoiding, as far as possible, the use of surgical practices. The most common and direct nonoperative application available for OA treatment is the viscosupplementation (VS) procedure that demonstrates a safe, effective method and is less painful for the patients. The most recent works dealing with the design, development, and validation of viscosupplement products in preclinical and clinical trials for OA treatment are overviewed herein. In general, despite the development of new products, hyaluronic acid continues to be among the most reported intra‐articular viscosupplement products used in clinical trials, typically used as an isolated product or conjugated with other biologicals or drugs, such as platelet‐rich plasma and corticosteroids (CS). However, this issue is still demanding innovation. Approaches comprising new biomaterials as VS products, with intrinsic bioactivity, economical, and environmental friendliness, are required.

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Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study

Abstract: Multicenter, independent, prospective, randomized controlled trial with level of evidence 1.

Cited by 29 publications

References 27 publications

Comment on “Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study”

Comment on “Efficacy of a single intra-articular injection of ultra-high molecular weight hyaluronic acid for hip osteoarthritis: a randomized controlled study”

Standard and Advanced Imaging of Hip Osteoarthritis. What the Radiologist Should Know

Engineering of Viscosupplement Biomaterials for Treatment of Osteoarthritis: A Comprehensive Review

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