Efficacy of a Topical Product Containing Purified Omental Lipids and Three Anti-Itching Compounds in the Treatment of Chronic Pruritus/Prurigo Nodularis in Elderly Subjects: A Prospective, Assessor-Blinded, 4-Week Trial with Transepidermal Water Loss and Optical Coherence Tomography Assessments

Ardigò, Marco; Franceschini, Chiara; Campione, Elena; Cosio, Terenzio; Lanna, Caterina; Bianchi, Luca; Milani, Massimo

doi:10.2147/ccid.s292636

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…28 Topical PEA 0.3% formulations decreased VAS and verbal itching rating scale (VRS) scores, reduced transepidermal water loss, and improved sleep quality in patients with chronic pruritus. 29,30 A phase II RCT of an oral CB2 agonist (lenabasum 5 mg, 20 mg, 40 mg daily) safely improved skin burden, patient-reported function, and inflammation and fibrosis under skin histology with diffuse cutaneous systemic sclerosis. 31 Cases of individual patients with recalcitrant inflammatory skin disease or preference for "natural" treatments, resolving with topical medical cannabinoids, are increasingly reported, 4,6,32,33 emphasizing the need for further, well-designed clinical trials assessing safety and efficacy in larger samples.…”

Section: Applications In Dermatologymentioning

confidence: 99%

Nanotechnology to deliver cannabinoids in dermatology

Adusumilli

Hazuka

Friedman

2021

Precision Nanomedicine

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Cannabis-derived compounds and therapies targeting the endocannabinoid system (ECS) benefit clinical conditions beyond current indications. As our understanding of the ECS in the skin continues to develop, cannabinoids rapidly show promise for treating cutaneous pathology. However, unstable pharmacokinetics, bioavailability, and skin permeability have been significant constraints on their utility in dermatology. As cannabinoids shift from commercial herbal preparations to prescription drugs, nano-sized drug delivery strategies can tackle these physiochemical limitations and allow welldesigned clinical trials to establish safety and efficacy. This review summarizes the latest evidence for cannabinoids for skin disease, details the challenges of formulating cannabinoids, and highlights how the success of nanomedicine across therapeutic fields can translate to novel nano-cannabinoid therapeutics in dermatology.

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Section: Applications In Dermatologymentioning

confidence: 99%

Nanotechnology to deliver cannabinoids in dermatology

Adusumilli

Hazuka

Friedman

2021

Precision Nanomedicine

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Sex-Dependent Skin Aging and Rejuvenation Strategies

Gerasymchuk,

Robinson,

Vardinska

et al. 2023

Dermato

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The skin, the largest external organ, serves as the primary defensive barrier against various environmental factors such as ultraviolet exposure, pollution, dietary habits, pathogens, and chemical compounds. Consequently, the skin reflects our age through visible signs of aging, such as wrinkles, age spots, dullness, and sagging. This review explores the gender-related aspects of cutaneous aging and the associated dermatological conditions. It highlights the different manifestations of aging in females and males that become evident after the age of 12, emphasizing the susceptibility to conditions such as seborrheic eczema, acne, and rosacea. Treatment strategies often vary between genders due to these disparities. While men tend to experience accelerated skin aging, most anti-aging products and strategies primarily target females. However, there has been a recent shift in men’s priorities, leading to increased interest in maintaining a youthful appearance and seeking cosmetic treatments. The manuscript covers a comprehensive range of modern dermal anti-aging and rejuvenation procedures, including plastic surgery, bio-revitalization methods, lasers, microneedling, and topical treatments. Additionally, it explores promising natural and synthetic therapeutics for combating age-related skin changes. The focus is on understanding the physiological aspects of gender-related cutaneous structure and aging to guide effective and tailored approaches in dermatological practice.

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Efficacy of a Topical Product Containing Purified Omental Lipids and Three Anti-Itching Compounds in the Treatment of Chronic Pruritus/Prurigo Nodularis in Elderly Subjects: A Prospective, Assessor-Blinded, 4-Week Trial with Transepidermal Water Loss and Optical Coherence Tomography Assessments

Cited by 2 publications

References 44 publications

Nanotechnology to deliver cannabinoids in dermatology

Nanotechnology to deliver cannabinoids in dermatology

Sex-Dependent Skin Aging and Rejuvenation Strategies

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