Efficacy of accelerated hydrogen peroxide<sup>®</sup>disinfectant on foot-and-mouth disease virus, swine vesicular disease virus and Senecavirus A

Hole, Kate; Ahmadpour, Faraz; Krishnan, Jay; Stansfield, Carol; Copps, John; Nfon, Charles

doi:10.1111/jam.13361

Cited by 16 publications

(15 citation statements)

References 17 publications

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“…19,20 However, little data exist regarding inactivation at shortened contact times. Our data indicate that exposure to a 5-day-old 1% Virkon ® S solution for at least 30 seconds resulted in complete inactivation of FMDV, whereas 60 seconds of contact with Virkon ® S was needed to inactivate SVDV.…”

Section: Discussionmentioning

confidence: 99%

Smart Card Decontamination in a High-Containment Laboratory

et al. 2018

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Validated procedures for decontamination of laboratory surfaces and equipment are essential to biosafety and biorisk programs at high-containment laboratories. Each high-containment laboratory contains a unique combination of surfaces, procedures, and biological agents that require decontamination methods tailored to specific facility practices. The Plum Island Animal Disease Center (PIADC) is a high-containment laboratory operating multiple biosafety level (BSL)-3, ABSL-3, and BSL-3 Ag spaces. The PIADC facility requires the use of federally issued smart cards, called personal identity verification (PIV) cards, to access information technology (IT) networks both outside and within the high-containment laboratory. Because PIV cards may require transit from the BSL-3 to office spaces, a validated procedure for disinfecting PIV card surfaces prior to removal from the laboratory is critical to ensure biosafety and biosecurity. Two high-risk select agents used in the PIADC high-containment laboratory are foot-and-mouth disease virus (FMDV) and swine vesicular disease virus (SVDV). We evaluated disinfection of PIV cards intentionally spotted with FMDV and SVDV using a modified quantitative carrier test and the liquid chemical disinfectant Virkon® S. Our experimental design modeled a worst-case scenario of PIV card contamination and disinfection by combining high concentrations of virus dried with an organic soil load and use of aged Virkon® S prepared in hard water. Results showed that FMDV and SVDV dried on PIV card surfaces were completely inactivated after immersion for 30 and 60 seconds, respectively, in a 5-day-old solution of 1% Virkon® S. Therefore, this study provided internal validation of PIADC biosafety protocols by demonstrating the efficacy of Virkon® S to inactivate viruses on contaminated smart cards at short contact times.

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Section: Discussionmentioning

confidence: 99%

Smart Card Decontamination in a High-Containment Laboratory

et al. 2018

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“…Many viruses have been found to be sensitive to hydrogen peroxide, including swine flu, rubella, rabies, and others [7,[9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Methodsmentioning

confidence: 99%

Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

Caruso

Prete

Lazzarino³

2020

Medical Hypotheses

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We reviewed the literature concerning the innate response from nasal and oral epithelial cells and their reaction to hydrogen peroxide (H 2 O 2 ). Hydrogen peroxide is produced physiologically by oral bacteria and plays a significant role in the balance of oral microecology since it is an important antimicrobial agent. In the epithelial cells, the enzyme superoxide dismutase catalyzes a reaction leading from hydrogen peroxide to the ion superoxide. The induced oxidative stress stimulates a local innate response via activation of the toll-like receptors and the NF-κB. Those kinds of reactions are also activated by viral infections. Virus-induced oxidative stress plays an important role in the regulation of the host immune system and the specific oxidant-sensitive pathway is one of the effective strategies against viral infections. Therefore, nose/mouth/throat washing with hydrogen peroxide may enhance those local innate responses to viral infections and help protect against the current coronavirus pandemic. We strongly encourage the rapid development of randomized controlled trials in both SARS-CoV-2 positive and negative subjects to test the preliminary findings from the in-vitro and in-vivo observational studies that we identified.

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“…Disinfectants containing AHP showed virucide activity against some human and animal viruses, such as bovine viral diarrhea virus (BVDV), feline calicivirus, and poliovirus, which also belongs to the Picornaviridae family. In 2016 AHP was shown to be an effective disinfectant against FMD virus, SVD virus, and senecavirus; but its efficacy is dependent on the dilution (1:20) and the contact period (10 min), which are greater than the manufacturer's recommendations [ 61 ].…”

Section: Senecavirus Infection In Swine During/after 2015mentioning

confidence: 99%

Update on Senecavirus Infection in Pigs

Leme

Alfieri

2017

Viruses

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Senecavirus A (SVA) is a positive-sense single-stranded RNA virus that belongs to the Senecavirus genus within the Picornaviridae family. The virus has been silently circulating in pig herds of the USA since 1988. However, cases of senecavirus-associated vesicular disease were reported in Canada in 2007 and in the USA in 2012. Since late 2014 and early 2015, an increasing number of senecavirus outbreaks have been reported in pigs in different producing categories, with this virus being detected in Brazil, China, and Thailand. Considering the novel available data on senecavirus infection and disease, 2015 may be a divisor in the epidemiology of the virus. Among the aspects that reinforce this hypothesis are the geographical distribution of the virus, the affected pig-producing categories, clinical signs associated with the infection, and disease severity. This review presents the current knowledge regarding the senecavirus infection and disease, especially in the last two years. Senecavirus epidemiology, pathogenic potential, host immunological response, diagnosis, and prophylaxis and control measures are addressed. Perspectives are focused on the need for complete evolutionary, epidemiological and pathogenic data and the capability for an immediate diagnosis of senecavirus infection. The health risks inherent in the swine industry cannot be neglected.

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Efficacy of accelerated hydrogen peroxide^®disinfectant on foot-and-mouth disease virus, swine vesicular disease virus and Senecavirus A

Cited by 16 publications

References 17 publications

Smart Card Decontamination in a High-Containment Laboratory

Smart Card Decontamination in a High-Containment Laboratory

Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

Update on Senecavirus Infection in Pigs

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Efficacy of accelerated hydrogen peroxide®disinfectant on foot-and-mouth disease virus, swine vesicular disease virus and Senecavirus A

Cited by 16 publications

References 17 publications

Smart Card Decontamination in a High-Containment Laboratory

Smart Card Decontamination in a High-Containment Laboratory

Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

Update on Senecavirus Infection in Pigs

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Product

Resources

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Efficacy of accelerated hydrogen peroxide^®disinfectant on foot-and-mouth disease virus, swine vesicular disease virus and Senecavirus A