Efficacy of acotiamide on postprandial distress syndrome and epigastric pain syndrome depending on the estimated gastric acid secretion level

Suzuki, Toshiaki; Ohba, Reina; Kataoka, Ei; Kudo, Yoshihisa; Zeniya, Akira; Segawa, Daisuke; Oikawa, Keisuke; Odashima, Masaru; Saga, Taiji; Kuramitsu, Tomoyuki; Sasahara, Hideaki; Yoneyama, Kazuo; Tomita, Takashi; Shimodaira, Yosuke; Iijima, Katsunori

doi:10.5056/jnm20190

Cited by 2 publications

(3 citation statements)

References 37 publications

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“…which is characterized by complaints of a disturbing early feeling of fullness and/or a feeling of fullness after eating, which occurs approximately three times in a week; and (b) epigastric pain syndrome (EPS) which is characterized by unpleasant epigastric pain and/or a burning sensation that occurs approximately once a week [5]. These diagnostic complaints must be consistent for three months, with the onset of symptoms persisting approximately six months before diagnosis [6].…”

Section: Case Reportmentioning

confidence: 99%

Low-FODMAP diet on postprandial distress syndrome type of functional dyspepsia with mixed type of irritable bowel syndrome patient: A case report

Djatioetomo,

Maharani,

Djatioetomo

et al. 2024

Narra J

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Functional dyspepsia is a complex collection of symptoms from the gastroduodenal, while irritable bowel syndrome (IBS) is a disease that chronically weakens gastrointestinal. The occurrences of both of these diseases are common; however, the new approach therapy introducing the low-FODMAP diet (low fructose, oligosaccharides, disaccharides, monosaccharides, and polyols) is rarely discussed. The aim of this case report was to present a case of functional dyspepsia with IBS mixed type treated with a low-FODMAP diet. A female 37 years old reported complaints of heartburn worsening over the last seven months. Based on IBS-symptom severity scale (IBS-SSS) assessment, the patient had 75% scale on belly pain and 50% abdominal distention, which interfered the daily activity significantly. The patient was diagnosed with functional dyspepsia subtype postprandial distress syndrome with IBS mixed type. In addition, the low-FODMAP diet was started immediately, together with pharmacological therapy (oral omeprazole and domperidone), and followed up each week. On the first week of evaluation, the patient was feeling much better as IBS-SSS assessment scores decreased, and the pharmacological therapy was stopped. On the second week of evaluation, the patient had no more complaints with IB-SSS assessment markedly decreased. This case highlights that low-FODMAP diet could be a new approach therapy for IBS that could improve the IBS symptoms.

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Section: Case Reportmentioning

confidence: 99%

Low-FODMAP diet on postprandial distress syndrome type of functional dyspepsia with mixed type of irritable bowel syndrome patient: A case report

Djatioetomo,

Maharani,

Djatioetomo

et al. 2024

Narra J

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“…The Rome IV criteria in part facilitate the design and performance of clinical studies in the field of FD 5 . To the best of our knowledge, there have been limited studies on domperidone or other prokinetics in adult patients with FD who are diagnosed based on the Rome IV criteria 14 …”

Section: Introductionmentioning

confidence: 99%

“…5 To the best of our knowledge, there have been limited studies on domperidone or other prokinetics in adult patients with FD who are diagnosed based on the Rome IV criteria. 14 In this pilot study we aimed to generate preliminary efficacy data on domperidone in the treatment of Chinese adult patients with FD diagnosed based on the Rome IV criteria in outpatient hospital setting, while exploring the feasibility of a future pivotal study in this population, including the identification of FD subtypes potentially sensitive to domperidone treatment.…”

mentioning

confidence: 99%

Treatment of functional dyspepsia in Chinese adult patients with domperidone: A multicenter, randomized, double‐blind, placebo‐controlled pilot study

Fang,

Lin,

et al. 2023

J of Digest Diseases

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AimsThis pilot study aimed to evaluate domperidone in the treatment of Chinese patients with functional dyspepsia (FD) diagnosed according to Rome IV criteria, including identification of FD subtypes that potentially respond better to domperidone.MethodsThis study was conducted at hospitals in China from Aug 2018 to Jul 2020. The study consisted of a 1‐week screening phase and a 2‐week double‐blind treatment phase. Participants were randomized to domperidone 10 mg or matching placebo tablets three times daily for 14 days. The primary endpoint was overall treatment effect (OTE) response rate after 2 weeks of therapy.ResultsThe study enrolled 160 patients, 80 in each group. The OTE response rate after 2 weeks therapy was numerically higher for domperidone (60.7%) compared with placebo (46.0%) (relative risk [RR], 1.318; 95% confidence interval [CI], 0.972‐1.787). The OTE response rates after 2 weeks by FD subtype for domperidone and placebo were 60.3% vs 54.9% for postprandial distress syndrome (PDS) (RR, 1.098; 95% CI, 0.750‐1.607) and 60.6% vs 35.2% for overlapping PDS‐epigastric pain syndrome (EPS) (RR, 1.722; 95% CI, 0.995‐2.980). Adverse events were reported by seven patients in the domperidone group and twelve patients in the placebo group. None of the adverse events in the domperidone group were serious or unexpected.ConclusionsDomperidone showed a positive pattern on OTE response rates after 2 weeks therapy compared to placebo in patients with FD as well as in subtypes of PDS and overlapping PDS‐EPS. No new safety signal was observed.This article is protected by copyright. All rights reserved.

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Efficacy of acotiamide on postprandial distress syndrome and epigastric pain syndrome depending on the estimated gastric acid secretion level

Abstract: published online; they have not yet been assigned to a journal issue. When these articles are published in an issue, they will be removed. Online First articles are copy-edited, typeset and approved by the authors before publication.

Cited by 2 publications

References 37 publications

Low-FODMAP diet on postprandial distress syndrome type of functional dyspepsia with mixed type of irritable bowel syndrome patient: A case report

Low-FODMAP diet on postprandial distress syndrome type of functional dyspepsia with mixed type of irritable bowel syndrome patient: A case report

Treatment of functional dyspepsia in Chinese adult patients with domperidone: A multicenter, randomized, double‐blind, placebo‐controlled pilot study

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