Efficacy of afoxolaner (NexGard®) on the treatment of myiasis caused by the New World screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

Cutolo, André Antonio; Perier, Nadège; Menz, Ingrid; Thyssen, Patrícia Jacqueline; Silva, Fabiano O.; Beugnet, Frédéric

doi:10.1016/j.vprsr.2021.100569

Cited by 8 publications

(15 citation statements)

References 32 publications

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“…Isoxazoline compounds such as fluralaner, afoxolaner, sarolaner and lotilaner are labeled for the treatment and control of fleas and ticks in dogs and cats. Additionally, effective off-label use of several isoxazolines has been reported for the treatment of mange mites in different animal species and primary myiasis caused by the New World screw worm fly, Cochliomyia hominivorax , and the Old World screw worm, Chrysomya bezziana , in dogs and cats [ 4 – 7 ]. The objective of the present study was to evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs naturally infested with D. hominis larvae.…”

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confidence: 99%

“…In companion animals, different drug classes including macrocyclic lactones, spinosyns and neonicotinoids have been used in the clinical management and control of cutaneous myiasis [ 5 , 7 , 13 , 14 ]. Recently, the off-label use of isoxazolines such as sarolaner and afoxolaner has been proven efficacious against myiasis caused by C. hominivorax in dogs [ 7 , 14 ], lotilaner against C. bezziana [ 6 ], and fluralaner for treating D. hominis in cats [ 15 ]. Herein, we describe the use of oral sarolaner, an isoxazoline, in the clinical management of D. hominis larvae infestation at a standard dose recommended for the treatment and control of fleas and ticks.…”

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Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

et al. 2021

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Background The human botfly, Dermatobia hominis, is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule that causes pruritus and pain. Typical treatment consists of sedation for removal of larvae by surgical incision or manual pressure. Medications to kill the larva before its extraction can reduce inflammation and discomfort and provide a less traumatic larval removal. Isoxazolines are broad-spectrum ectoparasiticides with larvicidal activity previously reported in the treatment of screwworm myiasis in companion animals. The aim of this study was to evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs caused by D. hominis larvae. Methods Ten short-haired mixed breed dogs naturally infested with D. hominis were enrolled. Clinical diagnosis was achieved by observation of skin nodules and visualization of larval motility through the lesion orifice. Sarolaner was administered at manufacturer recommended dose for fleas and ticks. Lesions were reexamined 24 h post-treatment and assessed for viability of larvae. Larvae were removed by digital compression and identified as D. hominis. Results Seventy-five D. hominis larvae were retrieved from ten dogs. No live larvae were observed, demonstrating 100% larvicidal efficacy of sarolaner. Skin lesions were healed 30 days post-treatment and new lesions were not observed. Conclusions Sarolaner seems to be effective as larvicidal treatment for dogs with furuncular myiasis, reducing discomfort caused by the presence of the larva in the skin and facilitating its safe removal. Graphical abstract

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Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

et al. 2021

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“…Furthermore, the rapid expulsion of larvae from the host tissue can reduce the risk of foreign body infection and the need to debride the lesion to remove the larvae [ 23 ]. Given the lack of guidance for treating myiasis in dogs, the use of systemic molecules should be recommended due to the above-mentioned advantages [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…macrocyclic lactones, nitenpyram and spinosad) [8,[11][12][13]. More recently, other parasiticides, such as isoxazolines, have been described for the effective treatment of cutaneous myiasis [11,14,15].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

et al. 2023

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Background The New World screwworm fly, Cochliomyia hominivorax, is widely distributed across South America. This parasitic insect is a significant cause of primary myiasis in animals, including dogs. There is an urgent need for a rapid and efficient treatment to improve the recovery of affected animals. In the present study we evaluated the potential of lotilaner for the treatment of myiasis caused by C. hominivorax larvae in naturally infested dogs. Lotilaner belongs to the isoxazoline class of chemical compounds and is marketed as Credelio™ for use against ticks and fleas in dogs and cats. Methods Eleven dogs with naturally acquired myiasis were enrolled in this study based on the severity of lesions and the number of identified larvae. All animals received a single oral administration of lotilaner at a minimum dose of 20.5 mg/kg body weight. After treatment, the number of expelled larvae, live or dead, was determined at 2, 6 and 24 h, and the larval expulsion rate, larvicidal effect and overall efficacy were calculated. After 24 h, the remaining larvae were removed, counted and identified. The lesions were cleaned, and palliative treatment was administered when necessary, according to the animal's health status. Results All larvae were identified as C. hominivorax. The larval expulsion rate was 80.5% and 93.0% at 2 and 6 h post-treatment, respectively. Lotilaner showed an overall efficacy of 100% at 24 h post-treatment. Conclusions Lotilaner demonstrated a rapid onset of action and a high efficacy against C. hominivorax. We therefore recommend lotilaner for the effective treatment of myiasis in dogs. Graphical Abstract

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“…Isoxazoline compounds such as uralaner, afoxolaner, sarolaner and lotilaner are labeled for the treatment and control of eas and ticks in dogs and cats. Additionally, effective off-label use of several isoxazolines have been reported for the treatment of mange mites in different animal species and primary myiasis caused by the New World screw worm y, Cochliomyia hominivorax, and the Old World screw worm, Chrysomya bezziana, in dogs and cats [4,7].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Sarolaner in the Clinical Management of Furuncular Myiasis in Dogs Naturally Infested with Dermatobia Hominis (Diptera: Cuterebridae)

Andriotti

Souza

Oliveira

et al. 2021

Preprint

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Background – The human botfly, Dermatobia hominis is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule that causes pruritus and pain. Typical treatment consists of sedation for removal of larvae by surgical incision or manual pressure. Medications to kill the larva before its extraction can reduce inflammation and discomfort, and provide a less traumatic larval removal. Isoxazolines are broad-spectrum ectoparasiticides with larvicidal activity previously reported in the treatment of screwworm myiasis in companion animals. The aim of this study was evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs caused by D. hominis larvae. Methods and materials – Ten short-haired mixed breed dogs naturally infested. Clinical diagnosis was achieved by observation of skin nodules and visualization of larval motility through the lesion orifice. Sarolaner was administered at manufacturer recommended dose for fleas and ticks. Lesions were reexamined 24 hours post-treatment and assessed for viability of larvae. Larvae were removed by digital compression and identified as D. hominis.Results – Seventy-five D. hominis larvae were retrieved from 10 dogs. No live larvae were observed, demonstrating 100% larvicidal efficacy of sarolaner. Skin lesions were healed 30 days post-treatment and new lesions were not observed.Conclusions – Sarolaner seems to be effective as larvicidal treatment for dogs with furuncular myiasis, reducing discomfort caused by the presence of the larva in the skin and facilitating its safe removal.

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Efficacy of afoxolaner (NexGard®) on the treatment of myiasis caused by the New World screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

Cited by 8 publications

References 32 publications

Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

Effectiveness of Sarolaner in the Clinical Management of Furuncular Myiasis in Dogs Naturally Infested with Dermatobia Hominis (Diptera: Cuterebridae)

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