Efficacy of albumin in critically ill patients

Finfer, Simon; Bellomo, Rinaldo; Myburgh, John; Norton, Robyn

doi:10.1136/bmj.326.7389.559

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Treatment focuses on the main causes of hypoalbuminemia rather than administering albumin. The results of several meta-analyses of albumin administration in hospitalised patients were inconsistent [15].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit

Yanni¹,

Lubis²,

Ali³

2019

Open Access Maced J Med Sci

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BACKGROUND: The use of albumin in the critical care setting is a very controversial issue. Low serum albumin concentration in critical illness is associated with a poor outcome. AIM: We aimed to evaluate the influence of albumin level in critically ill children to the length of stay and mortality in the Pediatric Intensive Care Unit (PICU) Haji Adam Malik General Hospital, Medan, Indonesia. METHODS: The study used an observational method with a cross-sectional design. The population of the study was all patients with major postoperative surgery and critically ill that admitted to the PICU at Haji Adam Malik Hospital from the period of June 2008 to September 2008. The albumin level of the subjects was determined on the first day admitted. RESULTS: The group with hypoalbuminemia (< 3 g/dL) was given albumin supplementation according to a protocol in the PICU. The group with hypoalbuminemia have an average length of stay 7.6 days (9.7%) and mortality of 12 subjects (36.4%). The group with normal albumin level have 4.7 days (5.0%) and mortality 13 subjects (37.1%). There was no significant effect of albumin level to mortality. CONCLUSION: Albumin level did not affect the length of stay and mortality in PICU.

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Section: Discussionmentioning

confidence: 99%

The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit

Yanni¹,

Lubis²,

Ali³

2019

Open Access Maced J Med Sci

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“…The Australia and New Zealand Intensive Care Society in collaboration with the Institute for International Health of the University of Sydney have recently completed recruitment to the "SAFE" (saline versus albumin fluid evaluation) study. 46 This is a randomized double-blind controlled trial comparing resuscitation using 4% albumin versus 0.9% normal saline in a heterogeneous sample of patients in the intensive care unit. The trial is designed to detect a 3% difference in 28 day mortality and will enroll 7,000 critically ill patients.…”

Section: Should We Treat a Low Serum Albumin?mentioning

confidence: 99%

Should Albumin Be Used to Correct Hypoalbuminemia in the Critically Ill? No

Al‐Khafaji¹,

Webb

2003

Transfus Alt Transfus Med

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SUMMARY Hypoalbuminemia is the consequence of a disease process and successful treatment of the underlying disease should result in a gradual return to normal serum albumin values. There are many theoretical useful properties of albumin that make achieving normal serum values an attractive proposition. The available literature does not support the use of albumin to correct hypoalbuminemia. In fact we might do more harm than good by infusing albumin.

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“…Reviews can also generate testable hypotheses. For example, the Cochrane albumin meta-analysis [13] motivated the Saline vs. Albumin Fluid Evaluation (SAFE) randomized trial [14]. Fluid-management strategies remain the subject of intensive investigation.…”

mentioning

confidence: 99%

Deleterious renal effects of hydroxyethyl starch 130/0.4 and 200/0.5 solutions

Davidson

2007

European Journal of Anaesthesiology

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Efficacy of albumin in critically ill patients

Cited by 14 publications

References 7 publications

The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit

The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit

Should Albumin Be Used to Correct Hypoalbuminemia in the Critically Ill? No

Deleterious renal effects of hydroxyethyl starch 130/0.4 and 200/0.5 solutions

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