Efficacy of Alternate-Day Dosing Versus Daily Dosing of Atorvastatin

Abstract

Alternate-day dosing of atorvastatin is an efficacious and safe alternative to daily dosing.

To compare the efficacy of alternate day versus everyday dosing of atorvastatin in hyperlipidemic rabbits

“…These findings are cohesive with Pramanik S et al, Jafari M et al, Matalka MS, et al and Aghosadeghi K and Zare et al [6][7][8][9] A prospective, open label, crossover study in 40 patients conducted by Pramanik S et al evaluating the efficacy of alternate day atorvastatin versus daily dosing showed that both treatment regimens significantly reduced TC and TG and LDL-C levels as compared to baseline. There was no statistically significant difference between the two groups in terms of reduction of TC, TG and LDL-C at 12 weeks of treatment.…”

“…7 Both the regimens were well tolerated and none of the patients had a significant elevation of liver enzymes or creatine kinase. Group wise comparison did not show any statistical difference in SGOT, SGPT and CK levels.…”

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

“…Added to its great potency in reducing LDL-C, these properties would, reasonably, make atorvastatin an 'ideal' statin for an alternate-day regimen. No wonder, therefore, that alternate-day atorvastatin administration was demonstrated as an effective and safe alternative to the 'conventional' daily dosing regimen in reducing serum LDL-C levels (15,17,18,22).…”

“…Many previous studies have attempted to use the alternate-day dosing regimen of statin administration in patients with hypercholesterolemia (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Results, however, have been controversial; being discouraging for short-half-life statins: lovastatin, fluvastatin, pravastatin, and simvastatin (12-14, 19, 20).…”

Efficacy of alternate day versus daily dosing of rosuvastatin

“…This concept is not without precedent; previous studies have evaluated alternate day dosing regimens with simvastatin and atorvastatin, and concluded that an alternate day dosing strategy could provide comparable LDL-C reductions with that of daily administration in patients with dyslipidemia, and provide some measure of cost savings (11)(12)(13). Accordingly, the present trial was designed to compare the efficacy of administering rosuvastatin on a daily basis versus on an alternate day basis for the treatment of dyslipidemia.…”