Efficacy of an agonist of <i>α</i>‐<scp>MSH</scp>, the palmitoyl tetrapeptide‐20, in hair pigmentation

Scalvino, S. Almeida; Chapelle, Albert de la; Hajem, N.; Lati, Elian; Gasser, Philippe; Choulot, J.; Michel, Lise; Hocquaux, M.; Loing, Estelle; Attia, J.; Wdzieczak‐Bakala, Joanna

doi:10.1111/ics.12494

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…A previous study showed that SIRT-1 enabled mitochondrial homeostasis against the stress caused by TNF-α-dependent mediators on the hair follicle and increased the stem cells in the hair follicle as a way of protection [ 44 ]. Another study concluded that the decrease in hair pigmentation in chronological aging might be prevented by increasing the levels of SIRT-1 [ 45 ]. In an experimental study, it was determined that arginine increased the expression of SIRT-1 and MMP-2, reduced myocardial fibrosis and prevented cell apoptosis in streptozotocin-induced diabetic rats [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

Demir

Çiçek

Orhan

et al. 2022

Biol Trace Elem Res

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The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI), shaved + ASI (4.14 mg/rat/day); (iii) group (ASI + MgB I), shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); and (iv) group (ASI + MgB II), shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day). On day 42, compared with the control group, while hair density ( p < 0.05, p < 0.01, and p < 0.0001, respectively) and anagen ratio ( p < 0.01, p < 0.01, and p < 0.001) increased in the ASI, ASI + MgB I, and ASI + MgB II groups, telogen ratio decreased ( p < 0.01, p < 0.01, and p < 0.001, respectively). In the molecular analysis, VEGF, HGF, and KGF-2 increased in the ASI ( p < 0.01, p < 0.01, and p < 0.05, respectively), ASI + MgB I ( p < 0.0001 for all), and ASI + MgB II ( p < 0.0001 for all) groups when compared to the control group. FGF-2 ( p < 0.01) and IGF-1 ( p < 0.001) were found to be increased in the ASI + MgB I and ASI + MgB II groups. SIRT-1 and β-catenin increased in the ASI ( p < 0.05 and p < 0.01), ASI + MgB I ( p < 0.001 for both), and ASI + MgB II ( p < 0.0001 for both) groups. Wnt-1 increased in the ASI + MgB I ( p < 0.001) and ASI + MgB II ( p < 0.0001) groups. In conclusion , the combination of ASI and MgB could promote hair growth by regulating IGF-1, FGF, KGF, HGF, VEGF, SIRT-1, Wnt, and β-catenin signal pathways. It was also established that ASI did not affect nail growth, whereas the MgB combination was effective using a higher dose of biotin. Supplementary Information The online version contains supplementary material available at 10.1007/s12011-022-03176-9.

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Section: Discussionmentioning

confidence: 99%

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

Demir

Çiçek

Orhan

et al. 2022

Biol Trace Elem Res

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“…PTP20, an α-MSH agonist, has been reported to enhance the expression of catalase and to decrease (by ~30%) the intracellular level of H 2 O 2 in both in vivo and in vitro studies. [ 10 ] Furthermore, PTP20 has shown to activate the melanogenesis process in vitro and ex vivo , which has shown to be correlated with elevated expression of MC1-R, TRP-1, and with the reduction in ASIP expression. It is also associated with modulation on TRP-2.…”

Section: Discussionmentioning

confidence: 99%

Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%)

Chavan¹

2022

International Journal of Trichology

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With aging, hair graying is a common sign resulting from complex regulation of melanogenesis. Multiple factors control the stimulation of melanogenesis at the level of the hair follicle, including melanin-stimulating hormone (MSH), adrenocorticotropic hormone, endothelin-1, prostaglandins, leukotrienes, neutrophils, fibroblast growth factor, nitric oxide, catecholamines, Vitamins, and minerals. Premature hair graying (PHG) has a major impact on the cosmesis, self-credibility, and social life of the affected individual. Currently, there is no medical treatment available for PHG. We present a case of a 25-year-old female with a history of graying of hair on the scalp. Clinical diagnosis revealed it as a case of premature graying/canities. She was prescribed a topical formulation (Greyverse solution) containing palmitoyl tetrapeptide 20, a biomimetic biopeptide of α -MSH for treating her PHG. The formulation was applied 1 mL twice daily directly on the affected part of the scalp. Hair supplements containing a combination of biotin and calcium pantothenate once daily orally were also prescribed. After 3 months, the patient showed some improvement, and the dose of the topical solution was reduced to 1 mL once daily. After 5 months, the patient achieved >90% conversion of gray hair to black hair.

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“…Regarding pharmacotherapy of PGH, although many agents, for example, p-amino benzoic acid, 15 calcium pantothenate, 12,13 palmitoyl tetrapeptide-20 lotion, 16 anti-aging compounds, 2 and herbal agents 17 have been used, the grades of recommendation are low (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Although, it is used in many settings, 16,19 we could not find any study, using melanocyte grafting for the purpose of treatment of PGH.…”

Section: Melanocyte Graftingmentioning

confidence: 95%

“…23 In cases of vitiligo, the melanocytes are more sensitive to oxidative damage 78 and are more prone to premature graying. 16 Another α-melanocyte-stimulating hormone (α-MSH) agonist, Melitane is also reported to reverse the premature graying of hair, 79 however, data regarding efficacy is very limited.…”

Section: Other Co-morbid Conditions and Occurrence Of Pghmentioning

confidence: 99%

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Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Mahendiratta

Sarma

Kaur

et al. 2020

Dermatologic Therapy

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Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus, and Google Scholar till January 20, 2019. Studies which reported risk factors, co-morbid conditions associated with PGH, its pharmacotherapy and reversal were included in the study. Although many risk factors are reported in literature, smoking, vitamin deficiency (B12, folic acid, and B7), mineral deficiency (low serum calcium and serum ferritin) are found to be associated with PGH. Other important risk factors are family history of PGH, obesity, high B.P, lack of exercise, drugs, genetic syndromes, dyslipidemia, thyroid disorders, hyperuricemia, and alteration in liver function. PGH is found to be an important marker of CAD, more so in case of smoker. Among different pharmacotherapeutic management options, low grade recommendation (2A) is given to calcium pantothenate, PABA, calcium pantothenate + PABA combination. Anu-tailam is the only herbal agent evaluated in clinical research settings. Finally, treating the accompanying pathologies led to the reversal of the disease in many cases. K E Y W O R D S co-morbidities, premature graying of hair, reversal, risk factors, treatment 1 | INTRODUCTION Hair graying is a part of aging, which typically starts around 34.2 ± 9.6 years (whites) to 43.9 ± 10.3 years (in blacks). 1 Premature graying of hair (PGH) is said to occur if hair graying starts before the age of 20 (Caucasians) and 30 years in Africans. 1-4 For Indian people, a cut off range of 25 years is suggested. 1,5 DOPA oxidase positive follicular melanocytes are the primary site of pigment production. Hair color basically depends on the eumelanin Abbreviations: BMD, bone mineral density; BMI, body mass index; CAD, coronary artery disease; DBP, diastolic blood pressure; FBS, fasting blood sugar; OR, odds ratio; PABA, paraamino benzoic acid; PGH, premature graying of hair; RCT, randomized controlled trials; SBP, systolic blood pressure; TERT, telomerase reverse transcriptase. Saniya Mahendiratta and Phulen Sarma have contributed equally to this study and both are considered as first authors.

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Efficacy of an agonist of α‐MSH, the palmitoyl tetrapeptide‐20, in hair pigmentation

Cited by 17 publications

References 33 publications

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%)

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

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