Efficacy of an emollient cream in the treatment of xerosis in diabetic foot: a double‐blind, randomized, vehicle‐controlled clinical trial

Martini, Jacques; Huertas, Carlos; Turlier, Virginie; Saint-Martory, C.; Delarue, Alain

doi:10.1111/jdv.14095

Cited by 15 publications

(13 citation statements)

References 7 publications

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“…Although the current clinical pharmacology study was not designed to assess therapeutic benefits associated with the products, the findings from the current study provide pharmacological evidence for the observed therapeutic benefits associated with V0034CR. Other randomized clinical trials have shown that V0034CR reduces the severity of ichthyosis in children, and improves xerosis in children with AD and in patients with diabetic foot, reduces flares and corticosteroid consumption, and reduces the severity of symptoms in children with mild‐to‐moderate AD …”

Section: Discussionmentioning

confidence: 99%

Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with dry skin

Vaillant

Georgescou

Rivollier

et al. 2019

J of Cosmetic Dermatology

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Background The stratum corneum plays an important protective physiological role in providing a barrier to preventing skin desiccation and penetration of external agents. Emollients are used commonly to improve barrier function and skin hydration. Aims The primary objective of this study was to evaluate the effect of an emollient, V0034CR cream, and its active ingredients, to restore the cutaneous barrier. Secondary objectives included assessment of the moisturizing activity of each product and tolerance. The study was not designed to evaluate therapeutic benefit. Methods In this randomized, double‐blind, 4‐arm crossover, clinical pharmacology study, the full emollient V0034CR, its vehicle formulation alone, or with glycerol, or petrolatum, was applied to the forearms of healthy volunteers (n = 51) with dry skin (Kligman score of 2 or 3). Cutaneous permeability by Trans Epidermal Water Loss (TEWL) and skin moisture content by corneometry were serially measured for 12 hours following application. An analysis of variance with repeated measures was performed on the evolution of TEWL and corneometry. Results V0034CR emollient significantly reduced mean TEWL compared to vehicle (P = .0018) and vehicle + glycerol (P = .0001) and significantly increased mean corneometry scores compared to vehicle (P < .0001) and vehicle + petrolatum (P < .0001). Conclusions The emollient V0034CR presented combined effects, with the petrolatum component improving skin barrier function, with a reduction in TEWL, and the glycerol component improving skin hydration.

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Section: Discussionmentioning

confidence: 99%

Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with dry skin

Vaillant

Georgescou

Rivollier

et al. 2019

J of Cosmetic Dermatology

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“…The first author (KF) described the adverse effects of daily sole washing, the risk area of the skin between the toes, and the importance of applying ointments after wiping or washing the skin to avoid stacking ointment. Foot hygiene was covered in the program and has been reported previously [38,39]; however, it was not included in the practice session due to the providers' work circumstances.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the development process and effects of a foot care program with educational tools for nurses and care workers as in-home service providers

Fujii

Stolt

2020

BMC Res Notes

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Objective: Nurses and care workers who provide in-home services play important roles in assessing and providing care for older people who lack foot self-care abilities. We aimed to evaluate the development process and effects of a foot care program with educational tools for nurses and care workers as in-home service providers. This is a process evaluation with a descriptive mixed-methods study of quantitative and qualitative data conducted from July to October 2019 in Japan. Results: Foot care education tools were developed to address the issues faced by participants with various work patterns and insufficient foot care education in Japan. The contents of these tools were discussed by a panel and reviewed by experts. Three outcomes were analyzed using descriptive statistics and Pearson's correlation. Changes in foot care practice scores were significantly correlated with performance scores. The evaluations of five of the eight field nurses suggested that excess information was included in the foot care booklet. Overall, 29 nurses and care workers showed higher than average evaluation scores [3.8-4.1 (standard deviation, 0.62-0.91)] for the motion pictures and PowerPoint presentation. A program according to this conceptual framework must be established and periodically evaluated for refinement.

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“…The xerosis assessment scale, [8][9][10][11] overall cutaneous score, 9,10 dryness area severity index score, 12 transepidermal water loss, 13 and skin hydration 13 have been used as indicators of dry skin. Skin hydration is affected by the amount of moisture in the stratum corneum, and can be used to quantitatively assess the severity of dry skin.…”

Section: Oe Et Almentioning

confidence: 99%

Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study

Oe¹,

Takehara²,

Noguchi³

et al. 2018

CWCMR

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Purpose: Foot fissure should be prevented in patients with diabetes due to the likelihood of subsequent diabetic ulcer. The purpose of this study was to investigate a cutoff point for skin hydration with fissure and the factors associated with low skin hydration in patients with diabetes. Subjects and methods: Subjects were patients with diabetes who visited the diabetic foot clinic and were evaluated for skin hydration on the heel between April 2008 and March 2015. Information about fissure, skin hydration, age, sex, autonomic neuropathy, angiopathy, and tinea pedis were collected from the medical charts. Skin hydration on the heel was measured using a moisture checker. Skin hydration was compared between heels with and without fissure, and a cutoff for skin hydration with fissure was determined using receiver operating characteristic analysis. Based on the determined cutoff, factors associated with lower skin hydration were analyzed using logistic regression analysis. Results: Participants comprised 693 patients. Mean±SD age was 66.8±10.8 years, and 57.0% of subjects were male. The frequency of fissures on the heels was 10.4%. Area under the receiver operating characteristic curve for skin hydration in the presence of fissure was 0.717. Twenty percent was selected as the cutoff point, offering sensitivity of 0.478 and specificity of 0.819. Logistic regression analysis showed correlations between three factors (male sex, tinea pedis, and room temperature) and skin hydration <20.0% (odds ratio [OR] 1.587, 95% CI 1. p=0.004; OR 1.548, p=0.005; and OR 0.900, p=0.021, respectively). Conclusion: To prevent heel fissures, moisturizing care should aim at achieving skin hydration of 20%. If skin hydration is <20%, prevention of fissures may warrant not only specialized moisturizing care but also consideration of treatment for tinea pedis.

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Efficacy of an emollient cream in the treatment of xerosis in diabetic foot: a double‐blind, randomized, vehicle‐controlled clinical trial

Abstract: Treatment with an emollient is effective for improving foot xerosis in patients with diabetes.

Cited by 15 publications

References 7 publications

Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with dry skin

Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double‐blind, crossover study in healthy volunteers with dry skin

Evaluation of the development process and effects of a foot care program with educational tools for nurses and care workers as in-home service providers

Skin hydration of the heel with fissure in patients with diabetes: a cross-sectional observational study

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