Efficacy of an Ibuprofen/Codeine Combination for Pain Management in Children Presenting to the Emergency Department with a Limb Injury: A Pilot Study

May, Sylvie Le; Gouin, Serge; Fortin, Christophe; Messier, Alexandre; Robert, Marie; Julien, Marilyse

doi:10.1016/j.jemermed.2012.06.027

Cited by 26 publications

(44 citation statements)

References 24 publications

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“…Studies were published between 1991 and 2014 (median year 2007) and were conducted in the United States ( n = 7), Canada (5), France (3), Italy (3), and Germany (2) and one each in Finland, New Zealand, and the United Kingdom. Most studies did not report on sources of funding ( n = 13), one specifically reported no funding [68], seven reported grant funding [13, 19, 62, 64, 66, 69, 75, 76], and two reported funding from industry [70, 75]. …”

Section: Resultsmentioning

confidence: 99%

How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review

Hartling

Ali

Dryden

et al. 2016

Pain Research and Management

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Background. Fear of adverse events and occurrence of side effects are commonly cited by families and physicians as obstructive to appropriate use of pain medication in children. We examined evidence comparing the safety profiles of three groups of oral medications, acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, to manage acute nonsurgical pain in children (<18 years) treated in ambulatory settings. Methods. A comprehensive search was performed to July 2015, including review of national data registries. Two reviewers screened articles for inclusion, assessed methodological quality, and extracted data. Risks (incidence rates) were pooled using a random effects model. Results. Forty-four studies were included; 23 reported on adverse events. Based on limited current evidence, acetaminophen, ibuprofen, and opioids have similar nausea and vomiting profiles. Opioids have the greatest risk of central nervous system adverse events. Dual therapy with a nonopioid/opioid combination resulted in a lower risk of adverse events than opioids alone. Conclusions. Ibuprofen and acetaminophen have similar reported adverse effects and notably less adverse events than opioids. Dual therapy with a nonopioid/opioid combination confers a protective effect for adverse events over opioids alone. This research highlights challenges in assessing medication safety, including lack of more detailed information in registry data, and inconsistent reporting in trials.

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Section: Resultsmentioning

confidence: 99%

How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review

Hartling

Ali

Dryden

et al. 2016

Pain Research and Management

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“…, Le May et al . in press), at a two‐sided alpha level of 0·05. To compensate for an estimated dropout rate of 52%, we needed an additional nine children per group.…”

Section: The Studymentioning

confidence: 99%

A randomized clinical trial of a nurse telephone follow‐up on paediatric tonsillectomy pain management and complications

Paquette

May

Fiola

et al. 2013

Journal of Advanced Nursing

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“…Various analgesic agents were compared: codeine versus ibuprofen, ibuprofen versus acetaminophen, and acetaminophen versus codeine (three-arm study) [ 45 ]; acetaminophen/codeine versus ibuprofen [ 46 ]; diamorphine versus morphine [ 49 ]; fentanyl/ibuprofen versus ketamine/ibuprofen [ 48 ]; and ketorolac versus tramadol [ 51 ]. Two studies compared fentanyl to morphine [ 44 , 47 ] and one study compared a combination of ibuprofen/codeine to ibuprofen/placebo [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…Pain was assessed in the eight studies using various one-dimensional pain scales: Visual Analog Scale (VAS) [ 44 , 45 , 48 , 50 , 51 ], Color Analog Scale (CAS) [ 46 ], Wong-Baker faces pain scale (WBS) [ 47 , 49 ], Faces Pain Scale-Revised (FPS-R) [ 48 ], and McGrath scale [ 51 ]. The primary outcome in all of the studies was the mean pain score difference.…”

Section: Resultsmentioning

confidence: 99%

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Pain Management of Pediatric Musculoskeletal Injury in the Emergency Department: A Systematic Review

May

Ali

Khadra

et al. 2016

Pain Research and Management

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Background. Pain management for children with musculoskeletal injuries is suboptimal and, in the absence of clear evidence-based guidelines, varies significantly. Objective. To systematically review the most effective pain management for children presenting to the emergency department with musculoskeletal injuries. Methods. Electronic databases were searched systematically for randomized controlled trials of pharmacological and nonpharmacological interventions for children aged 0–18 years, with musculoskeletal injury, in the emergency department. The primary outcome was the risk ratio for successful reduction in pain scores. Results. Of 34 studies reviewed, 8 met inclusion criteria and provided data on 1169 children from 3 to 18 years old. Analgesics used greatly varied, making comparisons difficult. Only two studies compared the same analgesics with similar routes of administration. Two serious adverse events occurred without fatalities. All studies showed similar pain reduction between groups except one study that favoured ibuprofen when compared to acetaminophen. Conclusions. Due to heterogeneity of medications and routes of administration in the articles reviewed, an optimal analgesic cannot be recommended for all pain categories. Larger trials are required for further evaluation of analgesics, especially trials combining a nonopioid with an opioid agent or with a nonpharmacological intervention.

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Efficacy of an Ibuprofen/Codeine Combination for Pain Management in Children Presenting to the Emergency Department with a Limb Injury: A Pilot Study

Cited by 26 publications

References 24 publications

How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review

How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review

A randomized clinical trial of a nurse telephone follow‐up on paediatric tonsillectomy pain management and complications

Pain Management of Pediatric Musculoskeletal Injury in the Emergency Department: A Systematic Review

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