Efficacy of an imidacloprid/flumethrin collar against fleas and ticks on cats

Abstract

BackgroundThe objectives of the studies listed here were to ascertain the therapeutic and sustained efficacy of 10% imidacloprid (w/w) and 4.5% flumethrin (w/w) incorporated in a slow-release matrix collar, against laboratory-infestations of fleas and ticks on cats. Efficacy was evaluated against the flea Ctenocephalides felis felis, and the ticks Ixodes ricinus, Amblyomma americanum and Rhipicephalus turanicus. The number of studies was so large that only a general overview can be presented in this abstract.MethodsPreventive efficacy was evaluated by infesting groups of cats (n = 8-10) with C. felis felis and/or I. ricinus, A. americanum or R. turanicus at monthly intervals at least, for a period of up to 8 months. Efficacy against fleas was evaluated 24 to 48 h after treatment and 24 h after infestation, and against ticks at 6 h (repellent) or 48 h (acaricidal) after infestation. Efficacy against flea larvae was evaluated over a period of 8 months by incubating viable flea eggs on blanket samples after cat contact. In all cases efficacy was calculated by comparison with untreated negative control groups.ResultsEfficacy against fleas (24 h) generally exceeded 95% until study termination. In vitro efficacy against flea larvae exceeded 92% until Day 90 and then declined to 67% at the conclusion of the study on Day 230.Sustained acaricidal (48 h) efficacy over a period of eight months was consistently 100% against I. ricinus from Day 2 after treatment, 100% against A. americanum, except for 98.5% and 97.7% at two time-points, and between 94% and 100% against R. turanicus.From Day 2 until 8 months after treatment the repellent (6 h), efficacy was consistently 100% against I. ricinus, and between 54.8% and 85.4% against R. turanicus.ConclusionThe rapid insecticidal and acaricidal properties of the medicated collars against newly- acquired infestations of fleas and ticks and their sustained high levels of preventive efficacy have been clearly demonstrated. Taking into account the seasonality of fleas and ticks, the collars have the potential to prevent the transmission of vector-borne diseases and other conditions directly associated with infestation throughout the season of parasite abundance.

Comparative Speed of Kill, Repellent (anti-feeding) and Acaricidal Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and a Fipronil/(S)-Methoprene/Eprinomectin/Praziquantel Spot-on (Broadline®) against Ixodes ricinus (Linné, 1758) on Cats

“…Speed of kill efficacy 6 h after infestation was also 100 % over the same period of time in two of the studies in which this attribute was tested (Stanneck et al 2012a). The speed of kill as well as repellent and acaricidal efficacy now recorded against weekly infestations of adult I. ricinus over a period of 4 weeks, are in agreement with those of the previous studies, as no ticks, dead or alive, were detected on the treated cats at any of the measured time points and assessment days.…”

“…In three previous studies the imidacloprid/flumethrin collars proved to be 100 % effective against laboratory-induced infestations of adult I. ricinus on domestic cats on Day 7 post-treatment and thereafter against re-infestation at 4-weekly intervals from Day 28 until 8 months later (Stanneck et al 2012a). Speed of kill efficacy 6 h after infestation was also 100 % over the same period of time in two of the studies in which this attribute was tested (Stanneck et al 2012a).…”

“…amitraz) (Halos et al 2011) -are contraindicated for the use in cats. Recently introduced slow-release matrix collars containing imidacloprid 10 % (w/w) /flumethrin 4.5 % (w/w) (Seresto ® , Bayer) have proven to be highly effective for up to 8 months against infestations of ixodid ticks and fleas on cats (Stanneck et al 2012a, Stanneck et al 2012b. Its acaricidal active flumethrin is the first on the market to provide acaricidal (killing) and repellent (anti-feeding) efficacy for the treatment and prevention of tick infestations on cats, thus preventing repelled parasites from taking a blood meal and thereby indirectly aids in the reduction of the risk of vectorborne disease transmission, as demonstrated for the prevention of transmission of Cytauxzoon felis by Amblyomma americanum ticks (Reichard et al 2013).…”

Repellency Effect of an Imidacloprid / Flumethrin (Seresto®) Controlled Release Polymer Matrix Collar against the Australian Paralysis Tick (Ixodes holocyclus) in Dogs

“…It has been shown to achieve long-term persistent efficacy of 8 months against fleas (Ctenocephalides felis felis) (Stanneck et al 2012b(Stanneck et al , 2012c) and 4 months against I. holocyclus on dogs (Smith et al 2013). The Seresto ® collar has also been shown to be highly effective in the prevention of trans mission of VBD from ticks to dogs (Dantas-Torres et al 2013).…”

Long-Term Efficacy of an Imidacloprid 10 % / Flumethrin 4.5 % Polymer Matrix Collar (Seresto®, Bayer) against the Australian Paralysis Tick (Ixodes holocyclus) in Dogs

“…The IVP is registered for use on dogs and cats in many countries including in the European Union, the United Kingdom, the United States of America and New Zealand. It has been shown to be efficacious for 8 months against fleas (Ctenocephalides felis felis) and ticks (Amblyomma americanum, Dermacentor reticulatus, Dermacentor variabilis, Ixodes ricinus, Ixodes scapularis, Rhipicephalus sanguineus and Rhipicephalus turanicus) on dogs and cats and additionally eliminates lice (Trichodectes canis) and mites (Sarcoptes scabiei) on dogs (Stanneck et al 2012b;Stanneck et al 2012c). Both of the active ingredients in the IVP are found in ectoparasiticides currently registered for use on dogs in Australia.…”