Efficacy of Analgesic Propofol/Esketamine and Propofol/Fentanyl for Painless Induced Abortion: A Randomized Clinical Trial

Abstract

Background. Patients have widely accepted abortion as a remedy for contraceptive failure all over the world. Esketamine is a new anesthetic, sedative, and analgesic drug. Fentanyl is an opioid receptor agonist and a commonly used sedative. It is necessary to choose appropriate sedative drugs for painless abortion. Methods. We selected 238 cases of painless induced abortion from January 2020 to January 2022. We collected surgical parameters, the performance of sedation, and postoperative scales with complications before and after the operation. SPSS 21.0 was used to analyze data. Results. Surgical indicators between intervention and control groups had no difference; the preoperative indicators including intraoperative bispectral index (BIS), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse oxygen saturation (SpO2) had no difference between the two groups. But after surgery, experiment groups had a higher value than the control group in these four indicators. The incidence of postoperative complications including nausea and vomit had no significant difference while the experiment group had a lower r -value than the control group in hypotension, bradycardia, decreased oxygen saturation, and respiratory depression. The postoperative VAS score and Ramsay score in the experimental group were lower than those in the control group. Conclusion. Since esketamine had better sedation performance, reduce the risk of cardiovascular and respiratory depression during sedation, and reduce the pain scale compared with fentanyl, we supported that propofol/esketamine is a good choice for patients receiving a painless induced abortion, and it is a sedation plan worth promoting and further analysis.

The median effective concentration of propofol in combination with different doses of esketamine during gastrointestinal endoscopy in adults

“…While propofol co-administration with 0.5 mg/kg esketamine, there was a significant increasein MBP after finishing induction, which may be due to the decrease of propofol dosage and the increase of cardiac output by esketamine ( Kamp et al, 2021 ). Similarly, Xin et al (2020) and Tu et al (2021) also showed that propofol combined with esketamine had better hemodynamic stability. In contrast to previous study ( Yang et al, 2021 ), our study found that esketamine 0.15 and 0.25 mg/kg groups had shorter recovery times than esketamine 0 and 0.5 mg/kg group.…”

Application of OFA-based ERAS for video-assisted thoracoscopic surgery in elderly patients with airway stenosis: A case report

“…ESK has effective anesthetic and analgesic effects, while still allowing spontaneous breathing and airway reflexes. [28] In addition, it can antagonize N-methyl-D-aspartic acid receptors, relax bronchial muscle activity, inhibit histamine-induced bronchial contraction, as well as reduce tracheal and bronchial muscle spasms. [29] ESK is effective and neuroprotective when used for the swallowing reflex, eye blink reflex, cough reflex and vomiting reflex during anesthesia.…”

Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial

“…Demographic data and case characteristics were recorded, such as age, sex, and body mass index (BMI). The primary outcome of this study was the success rate of sedation, which was defined as a composite endpoint including completion of the procedure, no requirement for rescue sedatives, and no manual or mechanical ventilation ( Borkett et al, 2015 ; Xin et al, 2022b ).…”