Efficacy of anlotinib in Chinese patients with metastatic breast cancer: A retrospective observational study

Abstract

Anlotinib, a multitarget tyrosine kinase inhibitor, can inhibit tumour angiogenesis proliferation, metastasis, promote vascular normalization, increase T cell and NK cell activity and infiltration, remodel tumour microenvironment and synergistic immune enhancement. Our study aimes to evaluate the efficacy of anlotinib in the treatment of advanced metastatic breast cancer (MBC) after multiple lines of therapy. Patients included were treated with anlotinib for advanced MBC in the Affiliated Cancer Hospital of Zhengzhou University from 1 January 2019 to 30 June 2023. The objective remission rate, disease‐free progression survival and adverse reactions were analysed. We compared and analysed the efficacy of anlotinib in the treatment of advanced metastatic breast cancer, which showed that ORR was 23.6% and DCR was 69.1%. The DCR of monotherapy was 66.7% and that of combination therapy was 69.6% in MBC patients. The combination therapy, combined with chemotherapy had the best effect (79.3%), combined with immunotherapy came second. In addition, the DCR (88.9%) was higher in MBC patients having received prior antiangiogenic therapy. According to the Kaplan–Meier (K‐M) survival estimate analysis, the mPFS was 4.17 months (95% CI, 1.758–6.582 months) in Her‐2 positive MBC patients, and 7.83 months (95% CI, 2.416–9.104) in Her‐2 negative MBC patients. The mPFS was 5.76 months (95% CI, 3.231–8.298 m) in HR positive MBC patients, 7.83 months (95% CI, 3.182–12.478 m) in TNBC patients. Fatigue (20.0%), hypertension (21.8%) and liver dysfunction (18.2%) were common adverse reactions, followed by bone marrow suppression (16.4%), anorexia (14.5%), hypothyroidism (14.5%) and diarrhoea (14.5%). Altogether, Anlotinib monotherapy or combination therapy provides a viable third (or above)‐line therapeutic strategy in patients with metastatic breast cancer. The adverse reactions of anlotinib are well tolerated and controllable.

Treatment of HER2-Positive Breast Cancer with Brain Metastases Using Anlotinib and Trastuzumab Deruxtecan: A Case Report

“… 27 , 28 Furthermore, anlotinib has demonstrated objective efficacy with manageable toxicity in advanced/ metastatic triple-negative or HER2− BC. 29 , 30 The combined administration of anlotinib and T-DXd resulted in significant efficacy against both intracranial and extracranial areas of the patient with HER2+ BCBM. Importantly, this treatment was associated with acceptable toxicity.…”