Efficacy of anterior debridement and bone grafting with fusion using internal fixation combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical tuberculosis

Luan, Haopeng; Li, Kai; Wang, Yao; Kahaer, Alafate; Sheng, Weibin; Maimaiti, Maierdan; Deng, Qiang

doi:10.21203/rs.3.rs-1508125/v1

Cited by 1 publication

(2 citation statements)

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“…Surgical treatment for spinal TB was proven to be effective, 12–14 and some studies have shown that surgical treatment was a favorable factor for the prognosis of patients with spinal TB. 15 , 16 And some studies advocated aggressive surgery for spinal TB.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Consequently, extensive attention has been given to shortening anti-TB chemotherapy to eliminate adverse consequences during tuberculosis management. 11 Surgical treatment for spinal TB was proven to be effective, [12][13][14] and some studies have shown that surgical treatment was a favorable factor for the prognosis of patients with spinal TB. 15,16 And some studies advocated aggressive surgery for spinal TB.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Features and Outcomes of Spinal Tuberculosis in Central China

Tang¹,

Fu²,

Zhou³

et al. 2022

IDR

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Purpose The appropriate management of spinal tuberculosis (TB) is challenging for clinicians and the key to treat spinal TB. Surgery and long course anti-TB chemotherapy may not be necessary to all situations. This study aimed to characterize the clinical features and factors affecting treatment outcomes. Patients and Methods A retrospective study of patients with spinal TB over a 5-year period at a teaching hospital in central China was conducted. Features of patients with spinal TB who received different treatment modalities and factors associated with patient outcomes at the end of chemotherapy were analyzed. Results Forty-five patients (21 men and 24 women) with spinal TB were available for analysis. The mean age was 55.39 ± 14.94 years. The most common vertebral area involved was the lumbar (42.2%). The mean number of vertebrae involved was 2.20 ± 0.59. 27 patients (60.0%) received surgical treatment, of which 21 (77.8%) received radical surgical treatment. Thirty-five patients (77.8%) had achieved a favorable status. Statistically, there was no significant correlation between favorable status and surgery, but among 27 surgical patients with spinal tuberculosis, patients receiving radical surgery tended to achieve good prognosis ( P = 0.010; odds ratio = 0.053; 95% confidence interval 0.006–0.493). Moreover, there was no significant difference between long course and short course of anti-TB chemotherapy in prognosis in different treatment modalities. Conclusion Although the patients with spinal TB who needed surgical treatment often got a better prognosis when they had radical surgery, surgery was not actually a factor for the favorable outcomes of patients with spinal TB. In different treatment modalities, there was no additional benefit in longer anti-TB chemotherapy periods.

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Section: Introductionmentioning

confidence: 99%