Efficacy of anti-ulcer drugs on the recovery of gastric mucosal glycoproteins with aspirin-induced gastric damage in rat

Abstract

The efficacy of two anti-ulcer drugs, Cimetidine and Cetraxate, on the mucus glycoproteins of gastric mucosa in the aspirin-induced gastric damage was studied in rats. Simultaneous or previous oral administration of Cimetidine or Cetraxate with aspirin reduced the diminution of the mucus glycoproteins which was occurred by aspirin administration. The recovery of the content of mucus glycoprotein in drug dosed rats occurred within 3 h after aspirin dosing and was nearly 90% of control at 5 h in all cases. Single administration of Cetraxate or Cimetidine produced an increase in the mucus glycoprotein content greater than that of the untreated control. Although a macroscopical method for the measurement of gastric damage was applied to this work, neither erosions nor linear ulcers were observed in all cases except the single administration of aspirin. The biochemical method used should be able to assess the efficacy of drugs on the mucosal lesion which cannot be expressed as the ulcer index.

Effects of the New Anti-Ulcer Agent KB-5492 on Experimental Gastric Mucosal Lesions and Gastric Mucosal Defensive Factors, as Compared to Those of Teprenone and Cimetidine.

“…They also demonstrated that mucosal glycoprotein content remained low after the macroscopic lesions had naturally diminished 9 hr after aspirin treatment (20). Moreover, the mucosal lesion formation in our study (shown in Table 2) is much more severe than that reported by Azuumi et al (20,28). Therefore, it is pre sumed that cimetidine could hardly restore the biochemical function (i.e., glycoprotein synth esis) in the gastric mucosa under such severe experimental conditions as in the present study, even though it could inhibit the macro scopic lesion formation.…”

Changes of Rat Gastric Mucus Glycoproteins in Cytoprotection: Influences of Prostaglandin Derivatives

“…The present authors have developed a convenient method for achieving these ob jectives. Using this method, quantitative and qualitative changes in mucus glycoproteins in gastric mucosa during the pathological [12][13][14], physiologic [15] and pharmaceutical [22] changes of the stomach have been obtained. In the present study, treatment with prosta glandin derivatives was found not to signifi cantly change mucosal mucus glycoprotein content either in corpus or antrum.…”

Effects of famotidine on gastric mucus of the rat

“…It is well documented that they act by inhibiting secretion of gastric acid and thus preventing the gastric mucosal barrier damage produced by HC1 [2]. On the other hand, a number of investigators are in agreement that cimetidine, apart from the above-mentioned mode of action, increases the production of gastric mucosal glycoproteins [1,7,11,12]. In a recent study dealing with the protective role of famotidine on aspirin-induced gastric mucosal lesions, electron microscopic observations revealed an increase in both the mucous granules and Golgi apparatus -where mucus is manufactured -within the surface epithelial cells in rats pretreated with famotidine [4].…”