Efficacy of antihistamine pretreatment in the prevention of adverse reactions to Hymenoptera immunotherapy: A prospective, randomized, placebo-controlled trial☆☆☆★★★

Brockow, Knut; Kiehn, Margaret; Riethmüller, Claudia; Vieluf, D.; Berger, Jürgen; Ring, Johannes

doi:10.1016/s0091-6749(97)70135-0

Cited by 145 publications

(74 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[65][66][67][68] In detail, it was reported that levocetirizine decreased the rate of SSR 68 and fexofenadine decreased the rate of LLR and cutaneous SSR 67 (Table 3). Importantly, effectiveness of VIT was not negatively influenced.…”

Section: Preventive Pretreatmentmentioning

confidence: 95%

EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy

Sturm

Varga

Roberts

et al. 2017

Allergy

395

528

View full text Add to dashboard Cite

Hymenoptera venom allergy is a potentially life‐threatening allergic reaction following a honeybee, vespid, or ant sting. Systemic‐allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate to severe with a risk of life‐threatening anaphylaxis. Patients should carry an emergency kit containing an adrenaline autoinjector, H1‐antihistamines, and corticosteroids depending on the severity of their previous sting reaction(s). The only treatment to prevent further systemic sting reactions is venom immunotherapy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Venom Immunotherapy as part of the EAACI Guidelines on Allergen Immunotherapy initiative. The guideline aims to provide evidence‐based recommendations for the use of venom immunotherapy, has been informed by a formal systematic review and meta‐analysis and produced using the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included representation from a range of stakeholders. Venom immunotherapy is indicated in venom‐allergic children and adults to prevent further moderate‐to‐severe systemic sting reactions. Venom immunotherapy is also recommended in adults with only generalized skin reactions as it results in significant improvements in quality of life compared to carrying an adrenaline autoinjector. This guideline aims to give practical advice on performing venom immunotherapy. Key sections cover general considerations before initiating venom immunotherapy, evidence‐based clinical recommendations, risk factors for adverse events and for relapse of systemic sting reaction, and a summary of gaps in the evidence.

show abstract

Section: Preventive Pretreatmentmentioning

confidence: 95%

EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy

Sturm

Varga

Roberts

et al. 2017

Allergy

395

528

View full text Add to dashboard Cite

show abstract

“…Brockow et al [52] showed that antihistamine pretreatment was associated with a much lower rate of discontinuation of VIT as a result of SR, a finding that contradicts those of previous studies [53]. Moreover, pretreatment with antihistamines can also increase the efficacy of immunotherapy, probably by inhibition of type 2 helper T-cell cytokine production [48].…”

Section: Systemic Reactions Caused By Venom Immunotherapymentioning

confidence: 94%

Key Issues in Hymenoptera Venom Allergy: An Update

Alfaya

Soriano-Gomis

Mera

et al. 2017

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

In this review, the Hymenoptera Allergy Committee of the SEAIC analyzes the most recent scientific literature addressing problems related to the diagnosis of hymenoptera allergy and to management of venom immunotherapy. Molecular diagnosis and molecular risk profiles are the key areas addressed. The appearance of new species of hymenoptera that are potentially allergenic in Spain and the associated diagnostic and therapeutic problems are also described. Finally, we analyze the issue of mast cell activation syndrome closely related to hymenoptera allergy, which has become a new diagnostic challenge for allergists given its high prevalence in patients with venom anaphylaxis.

show abstract

“…Obwohl keine kontrollierten Studien für die parallele Immuntherapie mit 2 Extrakten in gleicher Sitzung existieren, wird in der klinischen Praxis teilweise zwischen 2 Injektionen (an beiden [191,192]. Bei unerwünschten Begleitreaktionen, laut manchen Autoren auch generell [193], ist eine Prämedikation mit einem Antihistaminikum sinnvoll [194][195][196].…”

Section: Durchführung Und Applikationsformenunclassified