Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating

Pérez-Köhler, Bárbara; Linardi, Fábio; Pascual, Gemma; Bellón, Juan M.; Eglin, David; Guillaume, Olivier

doi:10.1007/s10029-019-02096-3

Cited by 14 publications

(14 citation statements)

References 26 publications

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“…The authors selected two different coating formulations-one based on antibiotics (gentamicin + rifampicin) and one based on an antiseptic (chlorhexidine). The results of this study showed that HApN, when loaded with drugs, inhibited the in vitro the growth of several Gram-positive and Gram-negative bacteria [92].…”

Section: Current Trendsmentioning

confidence: 69%

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

et al. 2021

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A parastomal hernia is a common complication following stoma surgery. Due to the large number of hernial relapses and other complications, such as infections, adhesion to the intestines, or the formation of adhesions, the treatment of hernias is still a surgical challenge. The current standard for the preventive and causal treatment of parastomal hernias is to perform a procedure with the use of a mesh implant. Researchers are currently focusing on the analysis of many relevant options, including the type of mesh (synthetic, composite, or biological), the available surgical techniques (Sugarbaker’s, “keyhole”, or “sandwich”), the surgical approach used (open or laparoscopic), and the implant position (onlay, sublay, or intraperitoneal onlay mesh). Current surface modification methods and combinations of different materials are actively explored areas for the creation of biocompatible mesh implants with different properties on the visceral and parietal peritoneal side. It has been shown that placing the implant in the sublay and intraperitoneal onlay mesh positions and the use of a specially developed implant with a 3D structure are associated with a lower frequency of recurrences. It has been shown that the prophylactic use of a mesh during stoma formation significantly reduces the incidence of parastomal hernias and is becoming a standard method in medical practice.

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Section: Current Trendsmentioning

confidence: 69%

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

et al. 2021

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“…Together, these results reveal a stronger effect and better long-term activity of the antibiotic compared to the antiseptic bioactive system. To the best of our knowledge, no previous data were reported comparing the effect of these two drugs relative to hernia mesh materials, except for another study recently carried out by us [ 35 ]. In alignment with this, a clinical trial on the use of antibacterial central venous catheters to reduce bloodstream infections revealed better performance of those devices containing rifampicin compared to others provided with chlorhexidine [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

et al. 2020

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The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against Staphylococcus aureus and Staphylococcus epidermidis (106 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials effectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.

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“…These PBSA2-g-Lv meshes prevented bacterial infection and promoted tissue regeneration in an in vivo wound-healing mouse model (Figure 4) [242]. A polymer-based hyaluronic acid-poly(N-isopropylacrylamide)(HApN) hydrogel that can be used as drugloaded coating of gentamicin and rifampicin applicable to different meshes to provide strong antimicrobial activity against S. aureus, MRSA, S. epidermidis and less against E. coliin vitro [243]. Polyvinyl alcohol (PVA) is another biomaterial hydrogel with excellent biocompatibility and water sorption properties [262].…”

Section: Meshes With Antibioticsmentioning

confidence: 99%

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

Serrano‐Aroca¹,

Pous‐Serrano²

2021

Preprint

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Worldwide, hernia repair represents one of the most frequent surgical procedures encompassing a global market valued at several billion dollars. This type of surgery usually requires the implantation of a mesh that needs the appropriate chemical, physical and biological properties for the type of repair. This review thus presents a description of the types of hernias, current hernia repair methods, and the state of the art of prosthetic meshes for hernia repair providing the most important meshes used in clinical practice by surgeons working in this area classified according to their biological or chemical nature, morphology and whether bioabsorbable or not. We emphasise the importance of surgical site infection in herniatology, how to deal with this microbial problem, and we go further into the future research lines on the production of advanced antimicrobial meshes to improve hernia repair and prevent microbial infections, including multidrug-resistant strains. A great deal of progress has been made in this biomedical field in the last decade. However, we are still far from an ideal antimicrobial mesh that can also provide excellent integration to the abdominal wall, mechanical performance, low visceral adhesion and minimal inflammatory or foreign body reactions, among many other problems.

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Efficacy of antimicrobial agents delivered to hernia meshes using an adaptable thermo-responsive hyaluronic acid-based coating

Cited by 14 publications

References 26 publications

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

The Role of Mesh Implants in Surgical Treatment of Parastomal Hernia

Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

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